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CLC number: R715.3

On-line Access: 2017-03-08

Received: 2016-05-06

Revision Accepted: 2016-09-30

Crosschecked: 2017-02-17

Cited: 1

Clicked: 4419

Citations:  Bibtex RefMan EndNote GB/T7714


Meng-kai Du


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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.3 P.263-271


Effects of pre-pregnancy body mass index and gestational weight gain on neonatal birth weight

Author(s):  Meng-kai Du, Li-ya Ge, Meng-lin Zhou, Jun Ying, Fan Qu, Min-yue Dong, Dan-qing Chen

Affiliation(s):  Department of Obstetrics and Gynecology, Womens Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China; more

Corresponding email(s):   Chendq@zju.edu.cn

Key Words:  Pre-pregnancy body mass index, Gestational weight gain, Neonatal birth weight, Appropriate weight gain pattern

Meng-kai Du, Li-ya Ge, Meng-lin Zhou, Jun Ying, Fan Qu, Min-yue Dong, Dan-qing Chen. Effects of pre-pregnancy body mass index and gestational weight gain on neonatal birth weight[J]. Journal of Zhejiang University Science B, 2017, 18(3): 263-271.

@article{title="Effects of pre-pregnancy body mass index and gestational weight gain on neonatal birth weight",
author="Meng-kai Du, Li-ya Ge, Meng-lin Zhou, Jun Ying, Fan Qu, Min-yue Dong, Dan-qing Chen",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Effects of pre-pregnancy body mass index and gestational weight gain on neonatal birth weight
%A Meng-kai Du
%A Li-ya Ge
%A Meng-lin Zhou
%A Jun Ying
%A Fan Qu
%A Min-yue Dong
%A Dan-qing Chen
%J Journal of Zhejiang University SCIENCE B
%V 18
%N 3
%P 263-271
%@ 1673-1581
%D 2017
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600204

T1 - Effects of pre-pregnancy body mass index and gestational weight gain on neonatal birth weight
A1 - Meng-kai Du
A1 - Li-ya Ge
A1 - Meng-lin Zhou
A1 - Jun Ying
A1 - Fan Qu
A1 - Min-yue Dong
A1 - Dan-qing Chen
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 3
SP - 263
EP - 271
%@ 1673-1581
Y1 - 2017
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600204

To evaluate the effects of maternal pre-pregnancy body mass index (pre-BMI) and gestational weight gain (GWG) on neonatal birth weight (NBW) in the population of Chinese healthy pregnant women, attempting to guide weight control in pregnancy. A retrospective cohort study of 3772 Chinese women was conducted. The population was stratified by maternal pre-BMI categories as underweight (<18.5 kg/m2), normal weight (18.5–23.9 kg/m2), overweight (24.0–27.9 kg/m2), and obesity (≥28.0 kg/m2). The NBW differences were tested among the four groups, and then deeper associations among maternal pre-BMI, GWG, and NBW were investigated by multivariate analysis. NBW increased significantly with the increase of maternal pre-BMI level (P<0.05), except overweight to obesity (P>0.05). The multivariate analysis showed that both pre-BMI and GWG were positively correlated with NBW (P<0.05). Compared with normal pre-BMI, underweight predicted an increased odds ratio of small-for-gestational-age (SGA) and decreased odds ratio for macrosomia and large-for-gestational-age (LGA), and the results were opposite for overweight. With the increase of GWG, the risk of SGA decreased and the risks of macrosomia and LGA increased. In addition, in different pre-BMI categories, the effects of weight gain in the first trimester on NBW were different (P<0.05). NBW is positively affected by both maternal pre-BMI and GWG, extreme pre-BMI and GWG are both associated with increased risks of abnormal birth weight, and maternal pre-BMI may modify the effect of weight gain in each trimester on NBW. A valid GWG guideline for Chinese women is an urgent requirement, whereas existing recommendations seem to be not very suitable for the Chinese.


方法:本文做了一个样本为3772例中国孕妇的回顾性研究。根据孕前体质量指数将人群分为四组,分别为低体重组(<18.5 kg/m2)、正常体重组(18.5-23.9 kg/m2)、超重组(24.0-27.9 kg/m2)和肥胖组(≥28.0 kg/m2)。比较这四组间新生儿出生体重 的差异,并用多元分析的方法探究孕前体质量指数、孕期增重和新生儿出生体重之间的关系。


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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[33]List of electronic supplementary materials

[34]Fig. S1 Proportions of LBW, macrosomia, SGA, and LGA in neonates from women in the four pre-BMI categories

[35]Table S1 Odds ratios for macrosomia, SGA, and LGA based on total GWG according to the criterions in the four GWG recommendations

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