JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE BDM

Accepted manuscript available online (unedited version)

Time-space regulation of biomimetic vascularization in 3D printed skeletal muscles

Author(s): Minxuan Jia, Tingting Fan, Tan Jia, Xin Liu, Heng Liu, and Qi Gu
Affiliation(s): State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, People’s Republic of China; Beijing Institute for Stem Cell and Regenerative Medicine, Chaoyang District, Beijing 100101, People’s Republic of China; University of Chinese Academy of Sciences, Huairou District, Beijing 100049, People’s Republic of China; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, People’s Republic of China; Department of Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, People’s Republic of China
Corresponding email(s): qgu@ioz.ac.cn
Key Words: skeletal muscle;vascularization;3D bioprinting;cell interaction

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Minxuan Jia,Tingting Fan,Tan Jia,Xin Liu,Heng Liu,and Qi Gu. Time-space regulation of biomimetic vascularization in 3D printed skeletal muscles[J]. Journal of Zhejiang University Science BDM,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1007/s42242-BDMJ-D-23-00272

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doi="https://doi.org/10.1007/s42242-BDMJ-D-23-00272"
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Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: In the intricate skeletal muscle tissue, the symbiotic relationship between myotubes and their supporting vasculature is pivotal in delivering essential oxygen and nutrients. This study delves deep into the nuanced interplay between skeletal muscle cells and endothelial cells in the vascularization of muscle tissue. By harnessing the capabilities of 3D bioprinting and modeling, we employed a groundbreaking approach: co-constructing endothelial and muscle cells, followed by their subsequent differentiation. Our findings underscore the profound impact of the interaction dynamics between these two cell types. Notably, introducing endothelial cells during the advanced phases of muscle differentiation enhanced myotube assembly. It spurred the development of the vascular network, paving the way for the early stages of vascularized skeletal muscle. The methodology highlighted in this research illuminates the potential for creating large-scale, physiologically aligned skeletal muscle. Furthermore, it accentuates the need for deeper explorations into the delicate equilibrium and mutual interactions between muscle and endothelial cells. Guided by the multi-cell-type interaction model, we foresee promising pathways for crafting even more intricate tissues or organs.

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