JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE BDM

Accepted manuscript available online (unedited version)

Reduced graphene oxide-mediated electron-hole separation in titanium dioxide for boosting photocatalytic antibacterial activity of bone scaffold

Author(s): Pei Feng, Haifeng Tian, Feng Yang, Shuping Peng, Hao Pan4, Cijun Shuai
Affiliation(s): State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China; NHC Key Laboratory of Carcinogenesis of Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha 410013, China; The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha 410078, China; Department of Periodontics & Oral Mucosal Section, Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha 410013, China; Institute of Additive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, China; College of Mechanical Engineering, Xinjiang University, Urumqi 830017, China
Corresponding email(s): panhao@csu.edu.cn, shuai@csu.edu.cn
Key Words: reduced graphene oxide, photocatalysis, reactive oxygen species, antibacterial properties, bone scaffold

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Pei Feng, Haifeng Tian, Feng Yang, Shuping Peng, Hao Pan4,Cijun Shuai. Reduced graphene oxide-mediated electron-hole separation in titanium dioxide for boosting photocatalytic antibacterial activity of bone scaffold[J]. Journal of Zhejiang University Science BDM,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1007/s42242-BDMJ-D-23-00372

@article{title="Reduced graphene oxide-mediated electron-hole separation in titanium dioxide for boosting photocatalytic antibacterial activity of bone scaffold",
author="Pei Feng, Haifeng Tian, Feng Yang, Shuping Peng, Hao Pan4,Cijun Shuai",
journal="Journal of Zhejiang University Science BDM",
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doi="https://doi.org/10.1007/s42242-BDMJ-D-23-00372"
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A1 - Hao Pan4
A1 - Cijun Shuai
J0 - Journal of Zhejiang University Science BDM
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doi="https://doi.org/10.1007/s42242-BDMJ-D-23-00372"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Fast electron-hole recombination in the photocatalysis process of titanium dioxide (TiO2) limits its application in preventing bacterial infection for bone defect repair. In this study, TiO2@reduced graphene oxide (rGO) composites were synthesized through a hydrothermal method, in which rGO with superior electrical conductivity promoted the separation of photoelectron-hole pairs of TiO2, thus improving the efficiency of photocatalytic production of reactive oxygen species (ROS). Subsequently, the TiO2@rGO composites were introduced into poly-l-lactic acid (PLLA) to prepare bone scaffold with photocatalytic antibacterial function via selective laser sintering. It showed that TiO2 grew on the surface of rGO and formed a covalent bond connection (Ti-O-C) with rGO. The electrochemical impedance of TiO2@rGO composites was decreased, and the transient photocurrent intensity was increased from 0.05 ?A/cm2 to 0.5 ?A/cm2 . The electron spin resonance resulted that the photocatalytic products of TiO2 were �OH and �O2 ? , which were two kinds of ROS that could kill bacteria via destroying Preprint of Bio-Design and Manufacturing (unedited) the bacterial membrane structure in vitro antibacterial experiment. The antibacterial rates of PLLA/TiO2@rGO scaffold against E. coli and S. aureus were 60% and 71%, respectively. Additionally, the scaffold exhibited enhanced mechanical properties due to the addition of TiO2@rGO as reinforcement phase and good biocompatibility for cell activity and proliferation.

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