JZUS - Journal of Zhejiang University SCIENCE

Frontiers of Information Technology & Electronic Engineering

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Numerical investigation of resolution in a single emitter localization-based imaging system

Author(s): Yueying WANG¹, Yiwen HU¹, Yuehan ZHAO¹, Cuifang KUANG^1, ^2, ³, Xiang HAO^1, ²
Affiliation(s): ¹College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China; more
Corresponding email(s): haox@zju.edu.cn
Key Words: localization precision; resolution; single-point positioning; oversampling; signal-to-noise ratio

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Yueying WANG¹, Yiwen HU¹, Yuehan ZHAO¹, Cuifang KUANG^1,^2,³, Xiang HAO^1,². Numerical investigation of resolution in a single emitter localization-based imaging system[J]. Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/FITEE.2500015

@article{title="Numerical investigation of resolution in a single emitter localization-based imaging system",
author="Yueying WANG¹, Yiwen HU¹, Yuehan ZHAO¹, Cuifang KUANG^1,^2,³, Xiang HAO^1,²",
journal="Frontiers of Information Technology & Electronic Engineering",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/FITEE.2500015"
}

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%A Xiang HAO^1
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Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: In this paper, we numerically analyze the factors determining localization precision and resolution in single emitter localization-based imaging systems. While previous studies considered a limited set of parameters, our numerical approach incorporates additional parameters with significant reference value, yielding a more comprehensive analysis of the results. We differentiate between the effects of additive and multiplicative noise on localization precision using numerical modeling. Additionally, we take the influence of sampling frequency into account and compute the optimal sampling frequency for varying resolution requirements. Leveraging a suite of derived equations, we systematically simulate and quantify how variations in these parameters influence system performance. Furthermore, we provide guidelines for optimizing signal-to-noise ratio (SNR) requirements and pixel size selection based on point spread function (PSF) width in single emitter localization-based imaging systems. This numerically driven research establishes a solid foundation, offering critical insights for the analysis of more complex imaging systems.

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