JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

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Biomimetic neurovascularized engineered muscle tissue for craniofacial volumetric muscle loss

Author(s): Sijia Ding, Shengjie Li, Zhuojie Shen, Yuhua Chen, Xia Wang, Jianxiang He, Huiming Wang, Mengfei Yu
Affiliation(s): Key Laboratory of Oral Biomedical Research of Zhejiang Province, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Cancer Center of Zhejiang University, Hangzhou 310006, China; The First Affiliated Hospital of Zhejiang University School of Medicine, School of Stomatology, and Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou, Zhejiang, 310003, China
Corresponding email(s): Mengfei Yu (yumengfei@zju.edu.cn), Huiming Wang (whmwhm@zju.edu.cn), Jianxiang He (hejianxiang@zju.edu.cn)
Key Words: Tissue engineering, biomimetics, masticatory muscles, biomaterials, regenerative medicine

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Sijia Ding, Shengjie Li, Zhuojie Shen, Yuhua Chen, Xia Wang, Jianxiang He, Huiming Wang, Mengfei Yu. Biomimetic neurovascularized engineered muscle tissue for craniofacial volumetric muscle loss[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/bdm.2400005

@article{title="Biomimetic neurovascularized engineered muscle tissue for craniofacial volumetric muscle loss",
author="Sijia Ding, Shengjie Li, Zhuojie Shen, Yuhua Chen, Xia Wang, Jianxiang He, Huiming Wang, Mengfei Yu",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/bdm.2400005"
}

%0 Journal Article
%T Biomimetic neurovascularized engineered muscle tissue for craniofacial volumetric muscle loss
%A Sijia Ding
%A Shengjie Li
%A Zhuojie Shen
%A Yuhua Chen
%A Xia Wang
%A Jianxiang He
%A Huiming Wang
%A Mengfei Yu
%J Journal of Zhejiang University SCIENCE B
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%@ 2095-9184
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/bdm.2400005"

TY - JOUR
T1 - Biomimetic neurovascularized engineered muscle tissue for craniofacial volumetric muscle loss
A1 - Sijia Ding
A1 - Shengjie Li
A1 - Zhuojie Shen
A1 - Yuhua Chen
A1 - Xia Wang
A1 - Jianxiang He
A1 - Huiming Wang
A1 - Mengfei Yu
J0 - Journal of Zhejiang University Science B
SP - 331�343
EP -
%@ 2095-9184
Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/bdm.2400005"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Craniofacial muscles represent essential components of the skeletal muscle system, contributing to critical physiological processes. Severe trauma can result in craniofacial volumetric muscle loss (VML), hindering the muscle regenerative process and leading to muscular facial deformities and functional impairment, as well as social isolation and psychological depression. Conventional therapies, involving muscle flap transposition or autologous tissue grafting, only achieve morphological repair but are ineffective in restoring muscle function, often causing complications of donor-area injury and sensory deficit. In this study, we successfully constructed a biomimetic engineered muscle tissue that integrates myofiber alignment, effective innervation, and blood perfusion, which can promote multiple tissue regeneration of the masseter area in vivo, making functional regeneration achievable. Based on light-controlled micropatterning technology, we generated mature muscle fibers with oriented alignment and established a neuromuscular co-culture system for in vitro neuromuscular junction (NMJ) reconstruction. Additionally, we designed and fabricated a vascular network structure to promote the vascularization of tissue, with hydrogel serving as the vehicle for assembling the composite engineered tissue. This technology enables the capability to customize the shape and dimension of the constructed entity to address diverse muscle defects, enabling the goal of personalized repair. In summary, this study provides a promising novel strategy for tissue regeneration that breaks through the current challenges in the treatment of craniofacial VML.

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