Journal of Zhejiang University SCIENCE  B

Accepted manuscript available online (unedited version)


Polypeptide-modified black phosphorus nanosheets as a brain-targeted neuroprotective agent for treating ischemic stroke


Author(s):  Meili Zhang (张媚丽), Taojian Fan (范涛健), Shujiang Yin (殷淑江), Jie Li (李洁), Jing Hou (侯靓), Ke Zhang (张珂), Bo Han (韩博), Wen Chen (陈文), Han Zhang (张晗) & Xing Tian (田星)

Affiliation(s):  Key Laboratory of Xinjiang Phytomedicine Resource and Utilization of Ministry of Education, School of Pharmacy, Shihezi University, Shihezi 832002, China; College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518000, China

Corresponding email(s):  hzhang@szu.edu.cn, tianxingdeyoujian@163.com

Key Words:  Black phosphorus nanosheets · Resveratrol · Polypeptide · Ischemic stroke · Blood–brain barrier · Drug deliv ery system


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Meili Zhang (张媚丽), Taojian Fan (范涛健), Shujiang Yin (殷淑江), Jie Li (李洁), Jing Hou (侯靓), Ke Zhang (张珂), Bo Han (韩博), Wen Chen (陈文), Han Zhang (张晗) & Xing Tian (田星) . Polypeptide-modified black phosphorus nanosheets as a brain-targeted neuroprotective agent for treating ischemic stroke[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/bdm.2400176

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author="Meili Zhang (张媚丽), Taojian Fan (范涛健), Shujiang Yin (殷淑江), Jie Li (李洁), Jing Hou (侯靓), Ke Zhang (张珂), Bo Han (韩博), Wen Chen (陈文), Han Zhang (张晗) & Xing Tian (田星) ",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/bdm.2400176"
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%T Polypeptide-modified black phosphorus nanosheets as a brain-targeted neuroprotective agent for treating ischemic stroke
%A Meili Zhang (张媚丽)
%A Taojian Fan (范涛健)
%A Shujiang Yin (殷淑江)
%A Jie Li (李洁)
%A Jing Hou (侯靓)
%A Ke Zhang (张珂)
%A Bo Han (韩博)
%A Wen Chen (陈文)
%A Han Zhang (张晗) & Xing Tian (田星)
%J Journal of Zhejiang University SCIENCE B
%P 391–409
%@ 2095-9184
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/bdm.2400176"

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T1 - Polypeptide-modified black phosphorus nanosheets as a brain-targeted neuroprotective agent for treating ischemic stroke
A1 - Meili Zhang (张媚丽)
A1 - Taojian Fan (范涛健)
A1 - Shujiang Yin (殷淑江)
A1 - Jie Li (李洁)
A1 - Jing Hou (侯靓)
A1 - Ke Zhang (张珂)
A1 - Bo Han (韩博)
A1 - Wen Chen (陈文)
A1 - Han Zhang (张晗) & Xing Tian (田星)
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doi="https://doi.org/10.1631/bdm.2400176"


Abstract: 
Ischemic stroke is the leading cause of death in China, accounting for approximately one-third of all stroke-associated deaths worldwide. Currently, thrombolysis is employed for ischemic strokes. However, due to the limited therapeutic window of thrombolytic agents, most patients do not receive the drug at the right time. Moreover, these agents are associated with risks of hemorrhage and reperfusion damage. Herein, Angiopep-2 (ANG)-black phosphorus (BP)-resveratrol (RES), a drug-loaded system, was used to deliver drugs across the blood–brain barrier (BBB). ANG-BP-RES has a uniform size, stable structure, good photothermal effect, and strong drug release ability under near-infrared (NIR) irradiation and acidic conditions. Further more, ANG-BP-RES can efficiently target the brain and improve BBB permeability, exerting a significant therapeutic effect against ischemic brain injury, especially after NIR irradiation. ANG-BP-RES is also biocompatible and shows minimal toxic ity toward cells and tissues. This study offers novel insights into the therapeutic management of ischemic brain injury.

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On-line Access: 2025-05-20

Received: 2024-05-05

Revision Accepted: 2024-09-21

Crosschecked: 0000-00-00

Cited: 0

Clicked: 919

Citations:  Bibtex RefMan EndNote GB/T7714

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