JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Mg2+ containing composite scaffolds mediate macrophage polarization to enhance meniscus regeneration

Author(s): Zong Li, Weili Shi, Ming Tian, Wenqiang Yan, Yifei Fan, Jin Cheng, Xiaoqing Hu, Xi Gong, Yingfang Ao
Affiliation(s): Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing, China; Beijing Key Laboratory of Sports Injuries, Beijing, China.; Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China; Civil Aviation General Hospital, Beijing, China.
Corresponding email(s): Gongxibjmu@sina.com, aoyingfang@163.com
Key Words: meniscus repair, magnesium, macrophage polarization, multifunctional composite hydrogel

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Zong Li, Weili Shi, Ming Tian, Wenqiang Yan, Yifei Fan, Jin Cheng, Xiaoqing Hu, Xi Gong, Yingfang Ao. Mg2+ containing composite scaffolds mediate macrophage polarization to enhance meniscus regeneration[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/bdm.2400313

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author="Zong Li, Weili Shi, Ming Tian, Wenqiang Yan, Yifei Fan, Jin Cheng, Xiaoqing Hu, Xi Gong, Yingfang Ao",
journal="Journal of Zhejiang University Science B",
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publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/bdm.2400313"
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%A Xi Gong
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doi="https://doi.org/10.1631/bdm.2400313"

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A1 - Xiaoqing Hu
A1 - Xi Gong
A1 - Yingfang Ao
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Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Meniscal injury, a prevalent and challenging medical condition, is characterized by poor self-healing potential and a complex microenvironment. Tissue engineering scaffolds, particularly those made of silk fibroin (SF)/hyaluronic acid methacryloy (HAMA) and encapsulating Mg2+, are promising options for meniscal repair. However, the inflammatory response following implantation is a significant concern. In this study, we prepared a composite SF/HAMA-Mg hydrogel scaffold, evaluated its physical and chemical properties, and detected its fibrochondrogenic differentiation effect in vitro and the healing effect in a rabbit meniscus defect model in vivo. Our results showed that the scaffold differentiates pro-inflammatory M1 macrophages into anti-inflammatory M2 macrophages after implantation, thereby reducing inflammation and facilitating the growth and repair of meniscus tissue. Further, the composite scaffold provided a conducive milieu for cell proliferation, anticipatory differentiation, and generation of extracellular matrix. In summary, composite SF/HAMA-Mg scaffolds display exceptional biocompatibility, anti-inflammatory properties, and superior potential for meniscus repair.

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