JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE

Accepted manuscript available online (unedited version)

Proteomic landscape of hydatidiform mole reveals molecular evolution and immune evasion in recurrence

Author(s): Mengyan TU^1, Shanshan XU^1, Xinru TU¹, Hankai SHI¹, Weiguo LU^1, ^2, ³, Junfen XU¹
Affiliation(s): ¹Department of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China ²Zhejiang Provincial Clinical Research Center for Obstetrics and Gynecology, Hangzhou 310058, China ³Zhejiang Key Laboratory of Maternal and Infant Health, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
Corresponding email(s): Weiguo LU, lbwg@zju.edu.cn Junfen XU, xjfzu@zju.edu.cn
Key Words: Hydatidiform mole; Recurrent HM; Proteomics; Immune microenvironment; Metabolic reprogramming; Recurrence risk

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Mengyan TU^1*, Shanshan XU^1*, Xinru TU¹, Hankai SHI¹, Weiguo LU^1,^2,³, Junfen XU¹. Proteomic landscape of hydatidiform mole reveals molecular evolution and immune evasion in recurrence[J]. Journal of Zhejiang University Science ,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.2500753

@article{title="Proteomic landscape of hydatidiform mole reveals molecular evolution and immune evasion in recurrence",
author="Mengyan TU^1*, Shanshan XU^1*, Xinru TU¹, Hankai SHI¹, Weiguo LU^1,^2,³, Junfen XU¹",
journal="Journal of Zhejiang University Science ",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.2500753"
}

%0 Journal Article
%T Proteomic landscape of hydatidiform mole reveals molecular evolution and immune evasion in recurrence
%A Mengyan TU^1*
%A Shanshan XU^1*
%A Xinru TU¹
%A Hankai SHI¹
%A Weiguo LU^1
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%A Junfen XU¹
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%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.2500753"

TY - JOUR
T1 - Proteomic landscape of hydatidiform mole reveals molecular evolution and immune evasion in recurrence
A1 - Mengyan TU^1*
A1 - Shanshan XU^1*
A1 - Xinru TU¹
A1 - Hankai SHI¹
A1 - Weiguo LU^{1
A1 -}^{2
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A1 - Junfen XU¹
J0 - Journal of Zhejiang University Science
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doi="https://doi.org/10.1631/jzus.2500753"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Hydatidiform mole (HM) is a gestational trophoblastic disease causing abnormal trophoblastic proliferation and pregnancy loss, often accompanied by a significant psychological burden. To elucidate the molecular basis and recurrence mechanisms of HM, we performed high-throughput proteomic profiling of FFPE villous tissues from 8 sporadic HM cases (HMS), 6 primary HM from recurrent cases (HMRP), 13 recurrent HM cases (HMR), and 8 normal villus cases (NV). A total of 2,959 differentially expressed proteins were identified, revealing immune dysregulation and metabolic reprogramming in HM. CD55 and ITGAM emerged as central network hubs of HM, while the recurrence-associated signature indicated altered extracellular matrix composition and the suppression of key transcriptional regulators (YAP1, STK3, POU2F1). Proteomic trajectory analysis from HMS to HMR highlighted the persistent downregulation of neutrophil degranulation and the upregulation of the immune checkpoint CD276 (B7-H3). These findings delineate the proteomic evolution and immune landscape of HM, offering molecular insights for recurrence risk assessment and potential targeted therapies for improved clinical management.

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