JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE A

Accepted manuscript available online (unedited version)

Design and fabrication of biomimetic four-region drug-laden cartilage scaffolds with porous hollow fibers

Author(s): Yu CHEN^1, ², Yuzhe MA^1, ², Jianzhong FU^1, ², Xinhua YAO^1, ²
Affiliation(s): ¹State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310058, China; more
Corresponding email(s): yaoxinhuame@zju.edu.cn
Key Words: Bionic design; 3D printing; Cartilage scaffold; Gradient porous structure; Regulation of mechanical properties; Drug delivery systems

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Yu CHEN^1,², Yuzhe MA^1,², Jianzhong FU^1,², Xinhua YAO^1,². Design and fabrication of biomimetic four-region drug-laden cartilage scaffolds with porous hollow fibers[J]. Journal of Zhejiang University Science A,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.A2400513

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author="Yu CHEN^1,², Yuzhe MA^1,², Jianzhong FU^1,², Xinhua YAO^1,²",
journal="Journal of Zhejiang University Science A",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.A2400513"
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Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Articular cartilage, which plays a vital role in joint structure, is susceptible to damage from trauma and degenerative joint diseases. Traditional methods for cartilage treatment often involve complex surgical procedures with limited efficacy. Alternatively, implantable drug-loaded scaffolds are an increasingly attractive cartilage treatment option. To address the challenges of structural and functional compatibility between scaffolds and native cartilage, as well as issues related to drug loading, we design a novel cartilage scaffold with a four-region hollow porous fiber network structure. Using an extrusion-based 3D printing platform, a biphasic silicone ink composed primarily of liquid-phase silicone and solid particles was employed to construct the hollow porous fiber network. Mechanical compression tests demonstrate that the cartilage scaffold has mechanical characteristics similar to those of native cartilage tissue, and ultraviolet spectrophotometry measurements confirm its ability to control drug release. These results showcase the feasibility and effectiveness of the proposed cartilage substitute structure.

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