JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE A

Accepted manuscript available online (unedited version)

Design and fabrication of biomimetic four-region drug-loaded cartilage scaffolds with porous hollow fibers

Author(s): Yu CHEN, Yuzhe MA, Jianzhong FU, Xinhua YAO
Affiliation(s): State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310058, China; more
Corresponding email(s): yaoxinhuame@zju.edu.cn
Key Words: Bionic design; 3D printing; Cartilage scaffold; Gradient porous structure; Regulation of mechanical properties; Drug delivery systems

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Yu CHEN, Yuzhe MA, Jianzhong FU, Xinhua YAO. Design and fabrication of biomimetic four-region drug-loaded cartilage scaffolds with porous hollow fibers[J]. Journal of Zhejiang University Science A,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.A2400513

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author="Yu CHEN, Yuzhe MA, Jianzhong FU, Xinhua YAO",
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year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.A2400513"
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%0 Journal Article
%T Design and fabrication of biomimetic four-region drug-loaded cartilage scaffolds with porous hollow fibers
%A Yu CHEN
%A Yuzhe MA
%A Jianzhong FU
%A Xinhua YAO
%J Journal of Zhejiang University SCIENCE A
%P 1070-1082
%@ 1673-565X
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.A2400513"

TY - JOUR
T1 - Design and fabrication of biomimetic four-region drug-loaded cartilage scaffolds with porous hollow fibers
A1 - Yu CHEN
A1 - Yuzhe MA
A1 - Jianzhong FU
A1 - Xinhua YAO
J0 - Journal of Zhejiang University Science A
SP - 1070
EP - 1082
%@ 1673-565X
Y1 - in press
PB - Zhejiang University Press & Springer
ER -
doi="https://doi.org/10.1631/jzus.A2400513"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Articular cartilage, which plays a vital role in joint structure, is susceptible to damage from trauma and degenerative joint diseases. Traditional methods for cartilage treatment often involve complex surgical procedures with limited efficacy. Alternatively, implantable drug-loaded scaffolds are an increasingly attractive cartilage treatment option. To address the challenges of structural and functional compatibility between scaffolds and native cartilage, as well as issues related to drug loading, we design a novel cartilage scaffold with a four-region hollow porous fiber network structure. Using an extrusion-based 3D printing platform, a biphasic silicone ink composed primarily of liquid-phase silicone and solid particles was employed to construct the hollow porous fiber network. Mechanical compression tests demonstrate that the cartilage scaffold has mechanical characteristics similar to those of native cartilage tissue, and ultraviolet spectrophotometry measurements confirm its ability to control drug release. These results showcase the feasibility and effectiveness of the proposed cartilage substitute structure.

仿生四区域药物负载软骨支架的设计与制造

作者：陈语^1,2，马宇哲^1,2，傅建中^1,2，姚鑫骅^1,2
机构：¹浙江大学，流体动力与机电系统国家重点实验室，中国杭州，310058；²浙江大学，浙江省3D打印工艺与装备重点实验室，中国杭州，310058
目的：关节软骨是关节功能的关键组成部分，但由于外伤和退行性疾病的影响，软骨极易受到损伤。传统的软骨治疗方法通常依赖复杂的手术程序，且疗效有限。作为一种潜在的替代方案，植入式载药支架逐渐成为一种有前景的软骨疾病治疗选择。然而，支架与天然软骨在结构与功能上的兼容性问题以及载药缓释功能的优化，仍然是当前面临的重大挑战。为了解决这些问题，本文提出了一种采用四区域中空多孔纤维网络结构的新型软骨支架设计。
创新点：1.提出了一种具有良好自支撑性能的双相有机硅油墨配方；2.提出了一种软骨支架的仿生设计，使支架具有与天然软骨相似的力学性能；3.软骨支架集成了由中空多孔纤维组成的药物输送系统，保证了稳定的药物释放性能。
方法：1.通过建模仿真，建立软骨支架压缩力学性能的数值模型（图4）；2.通过正交实验，确定软骨支架的纤维直径、纤维间距、纤维排列角等结构设计参数（表4）；3.使用液相硅胶和固体颗粒组成双相硅胶墨水，并利用挤出式3D打印平台制备支架。
结论：1.设计的仿生四区域中空多孔药物载体支架在结构与功能上高度接近天然软骨，具备良好的应用前景；2.设计的支架具备初始快速释放及后期持续释放的药物释放特性；3.生物相容性实验表明，设计的支架具有良好的生物相容性。

关键词组：仿生设计；3D打印；软骨支架；梯度多孔结构；力学性能调控；药物释放系统

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仿生四区域药物负载软骨支架的设计与制造

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