Journal of Zhejiang University SCIENCE  A

Accepted manuscript available online (unedited version)


3D printing of wet-bonded multilayer scaffolds for skin wound repair


Author(s):  Kangning SHEN1, 2, Jingyi GU3, Ximin YUAN4, Nian LIU4, Yinglin WANG3, Jiabin CAI1, 2, Yang SHI3, Kaiyang WANG4, Xinghua YE2, Minghao YANG2, Zhiyong MA1, 2, Zhijian XIE3

Affiliation(s):  1Zhejiang Key Laboratory of Industrial Solid Waste Thermal Hydrolysis Technology and Intelligent Equipment, Huzhou University, Huzhou 313000, China 2School of Engineering, Huzhou University, Huzhou 313000, China 3Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Zhejiang-Singapore International Joint Laboratory of Oral Bioengineering, Zhejiang Clinovation Pride, Hangzhou 310000, China 4State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310058, China

Corresponding email(s):  Zhiyong MA, 02641@zjhu.edu.cn Zhijian XIE, xzj66@zju.edu.cn

Key Words:  3D printing; Biomimetic skin; Wet adhesive; PCL modification; Genipin


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Kangning SHEN1,2, Jingyi GU3, Ximin YUAN4, Nian LIU4, Yinglin WANG3, Jiabin CAI1,2, Yang SHI3, Kaiyang WANG4, Xinghua YE2,Minghao YANG2, Zhiyong MA1,2, Zhijian XIE3. 3D printing of wet-bonded multilayer scaffolds for skin wound repair[J]. Journal of Zhejiang University Science A,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.A2500653

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journal="Journal of Zhejiang University Science A",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.A2500653"
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%T 3D printing of wet-bonded multilayer scaffolds for skin wound repair
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%A Kaiyang WANG4
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%J Journal of Zhejiang University SCIENCE A
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doi="https://doi.org/10.1631/jzus.A2500653"

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doi="https://doi.org/10.1631/jzus.A2500653"


Abstract: The skin repair process is significantly influenced by the regulation of a dynamic mechanical microenvironment. However, traditional single-layer scaffolds face limitations, including poor mechanical compatibility and weak interfacial adhesion. These drawbacks stem from their inability to mimic the multi-layered heterogeneous structure and functional synergy of natural skin. In this paper, a biomimetic skin extracellular matrix (ECM) scaffold with a layered structure BPS is proposed, consisting of three layers: a surface layer (SL), a support layer (PL), and a base layer (BL). The SL consists of a 3D-printed microporous polycaprolactone (PCL) structure, which simulates the epidermal barrier's antibacterial and breathable properties. The PL, a surface-modified multilayer PCL scaffold, mimics the dermal layer and provides essential mechanical support and elasticity. The BL, a hydrogel coated onto the surface of the PL, provides excellent biological properties. Genipin serves as a crosslinker, and ethylenediamine is used for amination treatment of the PCL scaffold surface. This chemical crosslinking strengthens interlayer connections, enhancing functional synergy and tripling the anti-swelling properties of the hydrogel. Additionally, it improves the wet adhesion of the scaffold to skin tissue, ensuring stable adherence to the wound surface. Compared to traditional scaffolds, this multilayer structure effectively integrates biological functions with mechanical performance, providing sustained protection and support during wound healing.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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On-line Access: 2026-03-03

Received: 2025-12-15

Revision Accepted: 2026-01-13

Crosschecked: 0000-00-00

Cited: 0

Clicked: 477

Citations:  Bibtex RefMan EndNote GB/T7714

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