JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE A

Accepted manuscript available online (unedited version)

3D printing of wet-bonded multilayer scaffolds for skin wound repair

Author(s): Kangning SHEN^1, ², Jingyi GU³, Ximin YUAN⁴, Nian LIU⁴, Yinglin WANG³, Jiabin CAI^1, ², Yang SHI³, Kaiyang WANG⁴, Xinghua YE², Minghao YANG², Zhiyong MA^1, ², Zhijian XIE³
Affiliation(s): ¹Zhejiang Key Laboratory of Industrial Solid Waste Thermal Hydrolysis Technology and Intelligent Equipment, Huzhou University, Huzhou 313000, China ²School of Engineering, Huzhou University, Huzhou 313000, China ³Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Zhejiang-Singapore International Joint Laboratory of Oral Bioengineering, Zhejiang Clinovation Pride, Hangzhou 310000, China ⁴State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310058, China
Corresponding email(s): Zhiyong MA, 02641@zjhu.edu.cn Zhijian XIE, xzj66@zju.edu.cn
Key Words: 3D printing; Biomimetic skin; Wet adhesive; PCL modification; Genipin

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Kangning SHEN^1,², Jingyi GU³, Ximin YUAN⁴, Nian LIU⁴, Yinglin WANG³, Jiabin CAI^1,², Yang SHI³, Kaiyang WANG⁴, Xinghua YE²,Minghao YANG², Zhiyong MA^1,², Zhijian XIE³. 3D printing of wet-bonded multilayer scaffolds for skin wound repair[J]. Journal of Zhejiang University Science A,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.A2500653

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author="Kangning SHEN^1,², Jingyi GU³, Ximin YUAN⁴, Nian LIU⁴, Yinglin WANG³, Jiabin CAI^1,², Yang SHI³, Kaiyang WANG⁴, Xinghua YE²,Minghao YANG², Zhiyong MA^1,², Zhijian XIE³",
journal="Journal of Zhejiang University Science A",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.A2500653"
}

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Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: The skin repair process is significantly influenced by the regulation of a dynamic mechanical microenvironment. However, traditional single-layer scaffolds face limitations, including poor mechanical compatibility and weak interfacial adhesion. These drawbacks stem from their inability to mimic the multi-layered heterogeneous structure and functional synergy of natural skin. In this paper, a biomimetic skin extracellular matrix (ECM) scaffold with a layered structure BPS is proposed, consisting of three layers: a surface layer (SL), a support layer (PL), and a base layer (BL). The SL consists of a 3D-printed microporous polycaprolactone (PCL) structure, which simulates the epidermal barrier's antibacterial and breathable properties. The PL, a surface-modified multilayer PCL scaffold, mimics the dermal layer and provides essential mechanical support and elasticity. The BL, a hydrogel coated onto the surface of the PL, provides excellent biological properties. Genipin serves as a crosslinker, and ethylenediamine is used for amination treatment of the PCL scaffold surface. This chemical crosslinking strengthens interlayer connections, enhancing functional synergy and tripling the anti-swelling properties of the hydrogel. Additionally, it improves the wet adhesion of the scaffold to skin tissue, ensuring stable adherence to the wound surface. Compared to traditional scaffolds, this multilayer structure effectively integrates biological functions with mechanical performance, providing sustained protection and support during wound healing.

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