Abstract: Over the course of the past 35 years, assisted reproductive technologies (ARTs) have been increasingly used worldwide, while debates on their safety have been generated. Birth defects and imprinting disorders were reported in previous research. Thus, the psychological development of children born following ARTs has become a major concern nowadays. This review gives a systematic view of psychological well-being of children conceived by different types of ART, including in vitro fertilization, intracytoplasmic sperm injection (ICSI), preimplantation genetic diagnosis/screening, and in vitro maturation. The previous studies are analyzed in three sections: (1) cognitive, motor, and language developments, (2) behavior problems and socio-emotional development, and (3) parent-child relationship. We conclude that although the majority of the studies on cognitive, motor, and language developments reported comparable achievements in the ART group vs. the naturally conceived group, lower intelligence quotient (IQ) scores, worse visual-motor ability or locomotor development, and delayed receptive language competence were found in the ART group. The results on the socio-emotional development were reassuring. As for the behavior problems, a higher prevalence of behavior problems existed in ART children; moreover, ICSI children were found to be at a higher risk of autism than the general population. Meanwhile, ART parents tended to have positive parental attitudes and be more protective of their children. Some suggestions for further research are also given in this review.

[1]Abidin, R., 1990. Parenting Stress Index Test Manual. Pediatric Psychology Press, Charlottesville, Virginia.

[2]Achenbach, T.M., 1991a. Manual for the Child Behavior Checklist/4–18 and 1991 Profiles. Department of Psychiatry, University of Vermont, Burlington, Vermont.

[3]Achenbach, T.M., 1991b. Manual for the Youth Self-Report and 1991 Profiles. Department of Psychiatry, University of Vermont, Burlington, Vermont.

[4]Achenbach, T.M., Edelbrock, C., 1983. Manual for the Child Behavior Checklist and Revised Child Behavior Profile. Department of Psychiatry, University of Vermont, Burlington, Vermont.

[5]Achenbach, T.M., Rescorla, L.A., 2000. Manual for ASEBA Preschool Forms & Profiles. Research Center for Children, Youth, & Families, University of Vermont, Burlington, Vermont.

[6]Achenbach, T.M., Rescorla, L.A., 2001. Manual of the ASEBA School-Age Forms & Profiles. Research Center for Children, Youth & Families, University of Vermont, Burlington, Vermont.

[7]Ainsworth, M., Blehar, M.C., Waters, E.C., Wall, S., 1978. The Strange Situation. Lawrence Erlbaum, Oxford, England.

[8]Armsden, G.C., Greenberg, M.T., 1987. The inventory of peer and parent attachment: individual differences and their relationship to psychological well-being in adolescence. J. Youth Adolesc., 16(5):427-454.

[9]Banerjee, I., Shevlin, M., Taranissi, M., Thornhill, A., Abdalla, H., Ozturk, O., Barnes, J., Sutcliffe, A., 2008. Health of children conceived after preimplantation genetic diagnosis: a preliminary outcome study. Reprod. Biomed. Online, 16(3):376-381.

[10]Barnes, J., Sutcliffe, A.G., Kristoffersen, I., Loft, A., Wennerholm, U., Tarlatzis, B.C., Kantaris, X., Nekkebroeck, J., Hagberg, B.S., Madsen, S.V., et al., 2004. The influence of assisted reproduction on family functioning and children’s socio-emotional development: results from a European study. Hum. Reprod., 19(6):1480-1487.

[11]Basatemur, E., Sutcliffe, A., 2008. Follow-up of children born after ART. Placenta, 29:S135-S140.

[12]Bayley, N., 1993. Bayley Scales of Infant Development, 2nd Ed. Harcourt Brace and Company, San Antonio, p.374.

[13]Beery, K.E., 1989. Developmental Tests of Visual-Motor Integration with Supplemented Developmental Test of Visual Perception and Motor Coordination. Modern Curriculum Press, Cleveland, Ohio.

[14]Beery, K.E., Buktenica, N.A., 1989. The VMI Developmental Test of Visual-Motor Integration. Modern Curriculum Press, Cleveland, Ohio.

[15]Bene, E., Anthony, J., 1985. Manual for the Family Relations Test. NFER-Nelson, Windsor, UK.

[16]Benjamin, J.S., Virginia, A.S., Pedro, R., 2009. Normal Child Development. Lippincott Williams & Wilkins, Philadelphia.

[17]Biringen, Z., Robinson, J., Emde, R.N., 1993. Emotional Availability Scales, 2nd Ed. Department of Human Development and Family Studies, Colorado State University, Fort Collins.

[18]Bleichrodt, N., Resing, W.C.M., Drenth, P.J.D., Zaal, J.N., 1987. Intelligentie-Meting Bij Kinderen: Empirische en Methodologische Verantwoording van de GeReviseerde Amsterdamse Kinder Intelligentie Test. Swets & Zeitlinger, Lisse, the Netherlands (in Dutch).

[19]Bzoch, K.R., League, R., 1991. Receptive-Expressive Emergent Language Test, 2nd Ed. Examiner’s Manual. PRO-ED, Austin, p.48.

[20]Centers for Disease Control and Prevention, American Society for Reproductive Medicine, Society for Assisted Reproductive Technology, 2010. 2008 Assisted Reproductive Technology Success Rates: National Summary and Fertility Clinic Reports. Department of Health and Human Services, Atlanta.

[21]Chang, A.S., Moley, K.H., Wangler, M., Feinberg, A.P., DeBaun, M.R., 2005. Association between Beckwith-Wiedemann syndrome and assisted reproductive technology: a case series of 19 patients. Fertil. Steril., 83(2):349-354.

[22]Colpin, H., Soenen, S., 2002. Parenting and psychosocial development of IVF-children. A follow-up study. Hum. Reprod., 17(4):1116-1123.

[23]Colpin, H., Bossaert, G., 2008. Adolescents conceived by IVF: parenting and psychosocial adjustment. Hum. Reprod., 23(12):2724-2730.

[24]Colpin, H., Demyttenaere, K., Vandemeulebroecke, L., 1995. New reproductive technology and the family. The parent-child relationship following in vitro fertilization. J. Child Psychol. Psyc., 36(8):1429-1441.

[25]Cousineau, T.M., Domar, A.D., 2007. Psychological impact of infertility. Best Pract. Res. Clin. Obstet. Gynaecol., 21(2):293-308.

[26]Cox, G.F., Bürger, J., Lip, V., Mau, U.A., Sperling, K., Wu, B.L., Horsthemke, B., 2002. Intracytoplasmic sperm injection may increase the risk of imprinting defects. Am. Soc. Hum. Genet., 71(1):162-164.

[27]DeBaun, M.R., Niemitz, L., Feinberg, A.P., 2003. Association of in vitro fertilization with Beckwith-Wiedemann Syndrome and epigenetic alterations of LIT1 and H19. Am. J. Hum. Genet., 72(1):156-160.

[28]de Graaf-Peters, V.B., Hadders-Algra, M., 2006. Ontogeny of the human central nervous system: what is happening when? Early Hum. Dev., 82(4):257-266.

[29]de Sonneville, L.M.J., 1999. Amsterdam Neuropsychological Tasks: A Computer-Aided Assessment Program. In: DenBrinker, B.P.L.M., Beek, P.J., Brand, A.N., Maarse, F.J., Mulder, L.J.M. (Eds.), Cognitive Ergonomics, Clinical Assessment and Computer-Assisted Learning: Computers in Psychology. Swets & Zeitlinger, Lisse, the Netherlands, p.187-203.

[30]Derogatis, L.R., 1994. SCL-90-R Symptoms Check List: Administration, Scoring and Procedures Manual. National Computoer Systems, Minneapolis, Minnesota.

[31]Duncan, S., Edwards, D., 1999. Lone Mothers, Paid Work and Gendered Moral Rationalities. Palgrave Macmillan Publishers Ltd., Basingstoke, UK.

[32]Engfer, A., Schneewind, K.A., 1976. Ein Fragebogen Selbstperzipiertes Elterlichen Erziehungseinstellungen. Trier University, Trier, Germany (in German).

[33]Erickson, M., Sroufe, L.A., Egeland, B., 1985. The Relationship Between Quality of Attachment and Behavior Problems in Preschool in a High Risk Sample. University of Chicago Press, Chicago.

[34]Fauser, B.C., Devroey, P., Macklon, N.S., 2005. Multiple birth resulting from ovarian stimulation for subfertility treatment. Lancet, 365(9473):1807-1816.

[35]Folio, M.R., Fewell, R.R., 2000. Peabody Developmental Motor Scales, 2nd Ed. PRO-ED, Austin, Texas.

[36]Gerris, J.R.M., Vermulst, A.A., Boxtel, D.A.A.M., van Janssens, J.M.A.M., van Zutphen, R.A.H., Felling, A.J.A., 1993. Parenting in Dutch Families: A Representative Description of Dutch Family Life in Terms of Validated Concepts Representing Characteristics of Parents, Children, the Family as a System and Parental Socio-cultural Value Orientations. Institute of Family Studies, University of Nijmegen, Nijmegen, the Netherlands.

[37]Gerris, L.A.W., Dekovic, M., Groenendaal, J.H.A., Noom, M.J., 1996. Parenting Behavior. In: Rispens, J., Hermanns, J.M.A., Meeus, W.H.J. (Eds.), Childrearing in the Netherlands. van Gorcum, Assen, p.41-69.

[38]Gibson, F.L., Ungerer, J.A., Leslie, G.I., Saunders, D.M., Tennant, C.C., 1998. Development, behaviour and temperament: a prospective study of infants conceived through in-vitro fertilization. Hum. Reprod., 13(6):1727-1732.

[39]Gibson, F.L., Ungerer, J.A., McMahon, C.A., Leslie, G.I., Saunders, D.M., 2000. The mother-child relationship following in vitro fertilisation (IVF): infant attachment, responsivity, and maternal sensitivity. J. Child Psychol. Psychiatry, 41(8):1015-1023.

[40]Gicquel, C., Gaston, V., Mandelbaum, J., Siffroi, J.P., Flahault, A., le Bouc, Y., 2003. In vitro fertilisation may increase the risk of Beckwith-Wiedemann syndrome related to the abnormal imprinting of the KCNQ1OT gene. Am. J. Hum. Genet., 72(5):1338-1341.

[41]Golombok, S., Cook, R., Bish, A., Murray, C., 1995. Families created by the new reproductive technologies: quality of parenting and social and emotional development of the children. Child Dev., 66(2):285-298.

[42]Golombok, S., Brewaeys, A., Cook, R., Giavazzi, M.T., Guerra, D., Mantovani, A., van Hall, E., Crosignani, P.G., Dexeus, S., 1996. The European study of assisted reproduction families: family functioning and child development. Hum. Reprod., 11(10):2324-2331.

[43]Golombok, S., MacCallum, F., Goodman, E., 2001. The “test-tube” generation: parent-child relationships and the psychological well-being of in vitro fertilization children at adolescence. Child Dev., 72(2):599-608.

[44]Golombok, S., Brewaeys, A., Giavazzi, M.T., Guerra, D., MacCallum, F., Rust, J., 2002. The European study of assisted reproduction families: the transition to adolescence. Hum. Reprod., 17(3):830-840.

[45]Golombok, S., Owen, L., Blake, L., Murray, C., Jadva, V., 2009. Parent-child relationships and the psychological well-being of 18-year-old adolescents conceived by in vitro fertilisation. Hum. Fertil., 12(2):63-72.

[46]Goodman, R., 1994. A modified version of the Rutter Parent Questionnaire including extra items on children’s 608 child development strengths: a research note. J. Child Psychol. Psychiatry, 35(8):1483-1494.

[47]Goodman, R., 1997. The Strengths and Difficulties Questionnaire: a research note. J. Child Psychol. Psychiatry, 38(5):581-586.

[48]Graham, P., Rutter, M., 1968. The reliability and validity of the psychiatric assessment of the child: II. Interview with the parent. Br. J. Psychiatry, 114(510):581-592.

[49]Griffiths, R., 1996. The Griffiths Mental Development Scales 1996. Association for Research in Infant and Child Development, the Test Agency, UK.

[50]Halliday, J., Oke, K., Breheny, S., Algar, E., Amor, D.J., 2004. Beckwith-Wiedemann syndrome and IVF: a case-control study. Am. J. Hum. Genet., 75(3):526-528.

[51]Harter, S., Pike, R., 1984. The pictorial scale of perceived competence and social acceptance for young children. Child Dev., 55(6):1969-1982.

[52]Helmerhorst, F.M., Perquin, D.A.M., Donker, D., Keirse, M.J.N.C., 2004. Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ, 328(7434):261-265.

[53]Henderson, S.E., Sugden, D.A., 1998. Movement Assessment Battery for Children. Handleiding. Swets & Zeitlinger B.V., Lisse, the Netherlands.

[54]Hetherington, E.M., 1992. Coping with marital transitions: a family system perspective. Monogr. Soc. Res. Child Dev., 57(2-3):1-14.

[55]Huntley, M., 1996. The Griffiths Mental Development Scales. 1996 Revision, the Test Agency, Henley, UK.

[56]Izat, Y., Goldbeck, L., 2008. The development of children from assisted reproduction—a review of the literature. Prax. Kinderpsychol. Kinderpsychiatr., 57(4):264-281 (in German).

[57]Jackson, R.A., Gibson, K.A., Wu, Y.W., Croughan, M.S., 2004. Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet. Gynecol., 103(3):551-563.

[58]John, K., Quinton, D., 1991. Child and Adolescent Functioning and Environment Schedule (Revised). MRC Child Psychiatry Unit, London.

[59]John, K., Gammon, G.D., Prusoff, B.A., Warner, V., 1987. The Social Adjustment Inventory for Children and Adolescents (SAICA): testing of a new semistructured interview. J. Am. Acad. Child Adolesc. Psychiatry, 26(6):898-911.

[60]Josse, D., 1997. Brunet-Lézine Révisé: Echelle de Developpement Psychomoteur de la Première Enfance. Issy-Les-Moulineaux, EAP, France (in French).

[61]Kaufman, A.S., 2001. Kaufman Assessment Battery for Children, Deutsche Version. Leiden University, Leiden.

[62]Knoester, M., Helmerhorst, F.M., van der Westerlaken, L.A.J., Walther, F.J., Veen, S., 2007. Matched follow-up study of 5‒8-year-old-ICSI singletons: child behaviour, parenting stress and child (health-related) quality of life. Hum. Reprod., 22(12):3098-3107.

[63]Knoester, M., Helmerhorst, F.M., Vandenbroucke, J.P., van der Westerlaken, L.A.J., Walther, F.J., Veen, S., 2008. Cognitive development of singletons born after intracytoplasmic sperm injection compared with in vitro fertilization and natural conception. Fertil. Steril., 90(2): 289-296.

[64]Koivurova, S., Hartikainen, A., Sovio, U., Gissler, M., Hemminki, E., Järvelin, M.R., 2003. Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF. Hum. Reprod., 18(11):2328-2336.

[65]Leslie, G.I., Gibson, F.L., McMahon, C., Cohen, J., Saunders, D.M., Tennant, C., 2003. Children conceived using ICSI do not have an increased risk of delayed mental development at 5 years of age. Hum. Reprod., 18(10):2067-2072.

[66]Leunens, L., Celestin-Westreich, S., Bonduelle, M., Liebaers, I., Ponjaert-Kristoffersen, I., 2006. Cognitive and motor development of 8-year-old children born after ICSI compared to spontaneously conceived children. Hum. Reprod., 21(11):2922-2929.

[67]Leunens, L., Celestin-Westreich, S., Bonduelle, M., Liebaers, I., Ponjaert-Kristoffersen, I., 2008. Follow-up of cognitive and motor development of 10-year-old singleton children born after ICSI compared with spontaneously conceived children. Hum. Reprod., 23(1):105-111.

[68]Lu, Y.H., Wang, N., Jin, F., 2013. Long-term follow-up of children conceived through assisted reproductive technology. J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 14(5):359-371.

[69]Ludwig, A.K., Katalinic, A., Thyen, U., Sutcliffe, A.G., Diedrich, K., Ludwig, M., 2009a. Neuromotor development and mental health at 5.5 years of age of singletons born at term after intracytoplasmatic sperm injection ICSI: results of a prospective controlled single-blinded study in Germany. Fertil. Steril., 91(1):125-132.

[70]Ludwig, A.K., Katalinic, A., Entenmann, A., Thyen, U., Sutcliffe, A.G., Diedrich, K., Ludwig, M., 2009b. Can we sense ART? The blinded examiner is not blind―a problem with follow-up studies on children born after assisted reproduction. Fertil. Steril., 92(3):950-952.

[71]Maher, E.R., Brueton, L.A., Bowdin, S.C., Luharia, A., Cooper, W., Cole, T.R., Macdonald, F., Sampson, J.R., Barratt, C.L., Reik, W., et al., 2003. Beckwith-Wiedemann syndrome and assisted reproduction technology (ART). J. Med. Genet., 40(1):62-64.

[72]McCarthy, D., 1972. Manual for the McCarthy Scales of Children’s Abilities. Psychological Corporation, New York.

[73]Middelburg, K.J., Heineman, M.J., Bos, A.F., Hadders-Algra, M., 2008. Neuromotor, cognitive, language and behavioural outcome in children born following IVF or ICSI: a systematic review. Hum. Reprod. Update, 14(3):219-231.

[74]Mu, S.C., Hwang, J.L., Lin, Y.H., Sung, T.C., Lin, M.I., Yeh, T.F., 2006. Growth and development of children conceived by in-vitro maturation of human oocytes. Early Hum. Dev., 82(10):677-682.

[75]Neemann, J., Harter, S., 1986. Manual of the Self-perception Profile for College Students. University of Denver, Denver.

[76]Nekkebroeck, J., Bonduelle, M., Desmyttere, S., van den Broeck, W., Ponjaert-Kristoffersen, I., 2008a. Mental and psychomotor development of 2-year-old children born after preimplantation genetic diagnosis/screening. Hum. Reprod., 23(7):1560-1566.

[77]Nekkebroeck, J., Bonduelle, M., Desmyttere, S., van den Broeck, W., Ponjaert-Kristoffersen, I., 2008b. Socioemotional and language development of 2-year-old children born after PGD/PGS, and parental well-being. Hum. Reprod., 23(8):1849-1857.

[78]Owen, L., Golombok, S., 2009. Families created by assisted reproduction: parent-child relationships in late adolescence. J. Adolesc., 32(4):835-848.

[79]Papaligoura, Z., Panopoulou-Maratou, O., Solman, M., Arvaniti, K., Sarafidou, J., 2004. Cognitive development of 12 month old Greek infants conceived after ICSI and the effects of the method on their parents. Hum. Reprod., 19(6):1488-1493.

[80]Place, I., Englert, Y., 2003. A prospective longitudinal study of the physical, psychomotor, and intellectual development of singleton children up to 5 years who were conceived by intracytoplasmic sperm injection compared with children conceived spontaneously and by in vitro fertilization. Fertil. Steril., 80(6):1388-1397.

[81]Ponjaert-Kristoffersen, I., Tjus, T., Nekkebroeck, J., Squires, J., Verté, D., Heimann, M., Bonduelle, M., Palermo, G., Wennerholm, U.B., 2004. Psychological follow-up study of 5-year-old ICSI children. Hum. Reprod., 19(12):2791-2797.

[82]Ponjaert-Kristoffersen, I., Bonduelle, M., Barnes, J., Nekkebroeck, J., Loft, A., Wennerholm, U.B., Tarlatzis, B.C., Peters, C., Hagberg, B.S., Berner, A., et al., 2005. International collaborative study of intracytoplasmic sperm injection-conceived, in vitro fertilization-conceived, and naturally conceived 5-year-old child outcomes: cognitive and motor assessments. Pediatrics, 115(3):E283-E289.

[83]Quinton, D., Rutter, M., 1988. Parenting Breakdown: The Making and Breaking of Intergenerational Links. Avebury Gower Publishing, Aldershot, UK.

[84]Reitan, R.M., 1979. Trail Making Test: TMT. Testzentrale, Germany.

[85]Richman, N., Stevenson, J., Graham, P.J., 1982. Pre-school to School: A Behavioural Study. Academic Press, London, p.225.

[86]Rohner, R.P., 1999. Handbook for the Study of Parental Acceptance and Rejection. University of Connecticut, Storrs, Connecticut.

[87]Rohner, R.P., Khaleque, A., 2005. Handbook for the Study of Parental Acceptance and Rejection. Rohner Research, Storrs, Connecticut.

[88]Rutter, M., Tizard, J., Whitmore, K., 1970. Education, Health and Behaviour. Longman, London.

[89]Rutter, M., Cox, A., Tupling, C., Berger, M., Yule, W., 1975. Attainment and adjustment in two geographical areas— the prevalence of psychiatric disorder. Br. J. Psychiatry, 126(6):493-509.

[90]Schieve, L.A., Meikle, S.F., Ferre, C., Peterson, H.B., Jeng, G., Wilcox, L.S., 2002. Low and very low birth weight in infants conceived with use of assisted reproductive technology. N. Engl. J. Med., 346(10):731-737.

[91]Soenens, B., Beyers, W., Vansteenkiste, M., Sierens, E., Luyckx, K., Goossens, L., 2004. The “Gross Anatomy” of Parenting Styles in Adolescence: Three or Four Dimensions? 18th Biennial Meeting of the International Society for the Study of Behavioural Development (ISSBD), Ghent, Belgium.

[92]Sparrow, S.S., Balla, D.A., Cicchetti, D.V., 1984. Vineland Adaptive Behavior Scales. American Guidance Service, Circle Pines, Minnesota.

[93]Steptoe, P., Edwards, R., 1978. Birth after the reimplantation of a human embryo. Lancet, 312(8085):366.

[94]Straus, M., 1979. Measuring intrafamily conflict and violence: the Conflict Tactics (CT) Scales. J. Marr. Fam., 41(1):75-88.

[95]Straus, M., 1980. Victims and aggressors in marital violence. Am. Behav. Sci., 23(5):681-704.

[96]Sutcliffe, A.G., Taylor, B., Li, J., Thornton, S., Grudzinskas, J.G., Lieberman, B.A., 1999. Children born after intracytoplasmic sperm injection: population control study. BMJ, 318(7185):704-705.

[97]Sutcliffe, A.G., Taylor, B., Saunders, K., Thornton, S., Lieberman, B.A., Grudzinskas, J.G., 2001. Outcome in the second year of life after in-vitro fertilisation by intracytoplasmic sperm injection: a UK case-control study. Lancet, 357(9274):2080-2084.

[98]Sutcliffe, A.G., Saunders, K., McLachlan, R., Taylor, B., Edwards, P., Grudzinskas, G., Lieberman, B.A., Thornton, S., 2003. A retrospective case-control study of developmental and other outcomes in a cohort of Australian children conceived by intracytoplasmic sperm injection compared with a similar group in the United Kingdom. Fertil. Steril., 79(3):512-516.

[99]Sutcliffe, A.G., Peters, C.J., Bowdin, S., Temple, K., Reardon, W., Wilson, L., Clayton-Smith, J., Brueton, L.A., Bannister, W., Maher, E.R., 2006. Assisted reproductive therapies and imprinting disorders―a preliminary British survey. Hum. Reprod., 21(4):1009-1011.

[100]Theunissen, N.C.M., Vogels, T.G.C., Koopman, H.M., Verrips, G.H., Zwinderman, K.A., Verloove-Vanhorick, S.P., Wit, J.M., 1998. The proxy problem: child report versus parent report in health-related quality of life research. Qual. Life Res., 7(5):387-397.

[101]van der Meulen, B., Ruiter, S., Spelberg, H., Smrkovsky, M., 2002. Bayley Scales of Infant Development-II. Dutch Version of the BSID-II, Specific Dutch Norms Included. Nederlandse Versie, the Netherlands.

[102]van der Steene, G., van Haasen, P.P., de Bruyn, E.E.J., Coetsier, P., Pijl, Y.L., Poortinga, Y.H., Spelberg, H.C., Spoelders-Claes, R., Stinissen, J., 1986. Wechsler Intelligence Scale for Children-Revised (English Version). Swets & Zeitlinger B.V., Lisse, the Netherlands.

[103]Verhulst, C., van der Ende, J., Koot, H.M., 1996. Handbook of CBCL/4-18 (Netherland Version). Erasmus University Rotterdam, the Netherlands.

[104]Verrips, G.H.W., Vogels, T.G.C., Koopman, H.M., Theunissen, N.C.M., Kamphuis, R.P., Fekkes, M.I.N.N., Wit, J.M., Verloove-Vanhorick, S.P., 1999. Measuring health-related quality of life in a child population. Eur. J. Public Health, 9(3):188-193.

[105]Vogels, T., Verrips, G.H., Verloove-Vanhorick, S.P., Fekkes, M., Kamphuis, R.P., Koopman, H.M., Theunissen, N.C., Wit, J.M., 1998. Measuring health-related quality of life in children: the development of the TACQOL parent form. Qual. Life Res., 7(5):457-465.

[106]Wagenaar, K., Huisman, J., Cohen-Kettenis, P.T., Delemarre-van de Waal, H.A., 2008a. An overview of studies on early development cognition, and psychosocial well-being in children born after in vitro fertilization. J. Dev. Behav. Pediatr., 29(3):219-230.

[107]Wagenaar, K., Ceelen, M., van Weissenbruch, M.M., Knol, D.L., Delemarre-van de Waal, H.A., Huisman, J., 2008b. School functioning in 8- to 18-year-old children born after in vitro fertilization. Eur. J. Pediatr., 167(11):1289-1295.

[108]Wagenaar, K., van Weissenbruch, M.M., Knol, D.L., Cohen-Kettenis, P.T., Delemarre-van de Waal, H.A., Huisman, J., 2009a. Behavior and socioemotional functioning in 9‒18-year-old children born after in vitro fertilization. Fertil. Steril., 92(6):1907-1914.

[109]Wagenaar, K., van Weissenbruch, M.M., Knol, D.L., Cohen-Kettenis, P.T., Delemarre-van de Waal, H.A., Huisman, J., 2009b. Information processing, attention and visual-motor function of adolescents born after in vitro fertilization compared with spontaneous conception. Hum. Reprod., 24(4):913-921.

[110]Wagenaar, K., van Weissenbruch, M.M., van Leeuwen, F.E., Cohen-Kettenis, P.T., Delemarre-van de Waal, H.A., Schats, R., Huisman, J., 2011. Self-reported behavioral and socioemotional functioning of 11- to 18-year-old adolescents conceived by in vitro fertilization. Fertil. Steril., 95(2):611-616.

[111]Wechsler, D., 1974. Wechsler Intelligence Scale for Children-Revised: Manual. The Psychological Corporation, New York.

[112]Wechsler, D., 1989. WPPSI-R: Wechsler Preschool and Primary Scale of Intelligence. Psychological Corporation, New York.

[113]Wechsler, D., 1990. Manual for the Wechsler Preschool and Primary Scale of Intelligence-Revised. Psychological Corporation, New York.

[114]Wechsler, D., 1995. Manuel: Echelle d’intelligence de Wechsler Pour la Période Préscolaire et Primaire. Forme Réviseé. ECPA, Paris (in French).

[115]Wechsler, D., 1999. Wechsler Abbreviated Scale of Intelligence. Psychological Corporation, New York.

[116]Williams, J.G., Higgins, J.P., Brayne, C.E., 2006. Systematic review of prevalence studies of autism spectrum disorders. Arch. Dis. Child, 91(1):8-15.

[117]World Health Organization, 2010. Infertility. Available from http://www.who.int/reproductivehealth/topics/infertility/en/index.html [Accessed on Sept. 5, 2010].

[118]Zimmer, R., Volkamer, M., 1987. MOT 4–6, Motoriktest fvr 4–6 Jahrige Kinder. Hogrefe, Gottingen (in German).

[119]Zink, I., Lejaegere, M., 2003. N-CDI’s Lijsten Voor Communicatieve Ontwikkeling: Korte Vormen. Acco, Leuven/Leusden (in Dutch).