JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Transmission risk of patients with COVID-19 meeting discharge criteria should be interpreted with caution

Author(s): Jun-Wei Su, Wen-Rui Wu, Guan-Jing Lang, Hong Zhao, Ji-Fang Sheng
Affiliation(s): Department of Infectious Diseases, State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for the Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Corresponding email(s): jifang_sheng@zju.edu.cn
Key Words: Coronavirus disease 2019 (COVID-19); severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Real-time polymerase chain reaction (RT-PCR)

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Jun-Wei Su, Wen-Rui Wu, Guan-Jing Lang, Hong Zhao, Ji-Fang Sheng. Transmission risk of patients with COVID-19 meeting discharge criteria should be interpreted with caution[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2000117

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doi="https://doi.org/10.1631/jzus.B2000117"
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Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: As of Apr. 22, 2020, the World Health Organization (2020) has reported over 2.4 million confirmed coronavirus disease 2019 (COVID-19) patients and 169 151 deaths. Recent articles have uncovered genomic characteristics and clinical features of COVID-19 (Chan et al., 2020; Chang et al., 2020; Guan et al., 2020; Zhu et al., 2020), while our understanding of COVID-19 is still limited. As suggested by guidelines promoted by the General Office of National Health Commission of the People’s Republic of China (2020) (from Versions 1 to 6), discharged standards for COVID-19 were still dependent on viral real-time polymerase chain reaction (RT-PCR) tests of respiratory specimens, showing that recovered COVID-19 patients with twice negative RT-PCR could meet discharge criteria. Here, we examined two cases in which nucleic acid test results were inconsistent with clinical and radiological findings, leading to suboptimal care.

需谨慎考虑符合出院标准的2019冠状病毒病患者的传染性

概要:目前全球新型冠状病毒流行形势仍严峻且持续恶化.评估符合出院标准的2019冠状病毒病(COVID-19)患者的传染性对于疾病控制至关重要.本研究报告两例核酸检测结果与临床表现及影像学表现不相符的患者,以此来呼吁临床工作者谨慎考虑符合出院标准的COVID-19患者的传染性.
关键词组：2019冠状病毒病(COVID-19);新型冠状病毒(SARS-CoV-2);实时聚合酶链式反应(RT-PCR)

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Reference

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[4]General Office of National Health Commission of the People’s Republic of China, 2020. Diagnosis and treatment of pneumonitis caused by new coronavirus (Trial Version 6). http://www.nhc.gov.cn/yzygj/s7653p/202002/8334a8326dd94d329df351d7da8aefc2.shtml [Accessed on Feb. 20, 2020] (in Chinese).

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[7]Shi HS, Han XY, Jiang NC, et al., 2020. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis, 20(4):425-434.

[8]World Health Organization, 2020. Coronavirus disease (COVID-19) pandemic. World Health Organization. https:// www.who.int/emergencies/diseases/novel-coronavirus-2019 [Accessed on Apr. 22, 2020].

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需谨慎考虑符合出院标准的2019冠状病毒病患者的传染性

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