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On-line Access: 2023-02-05
Received: 2022-08-21
Revision Accepted: 2022-10-26
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Yuzhu XU, Pan FAN, Lei LIU, Xuanfei XU, Lele ZHANG, Jiadong WANG, Yuao TAO, Xiaolong LI, Xi LI, Yuntao WANG. Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2200410 @article{title="Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway", %0 Journal Article TY - JOUR
间充质干细胞移植治疗的新视角:靶向铁死亡通路1东南大学医学院,中国南京市,210009 2东南大学附属中大医院脊柱外科中心,中国南京市,210009 3东南大学附属中大医院核医学科,中国南京市,210009 概要:体外培养扩增的间充质干细胞(MSCs)因具有愈合损伤组织的能力而被研究。MSCs的移植可促进受损组织的修复,并且能分化为目标细胞或是对存活的目的细胞起保护作用。但目前MSCs的移植修复效率受限于被移植到目标区域后,MSCs的存活率低。因此,现在迫切需要制定提高MSCs修复效率的策略。铁含量过载、活性氧蓄积以及抗氧化性能的下降均会抑制MSCs的增殖和再生能力,从而加速MSCs的死亡过程。值得注意的是,铁离子含量过载引发的氧化应激(OS)及伴随其后的抗氧化系统失衡是铁死亡发生的经典通路。因此我们认为,铁死亡通路可能抑制MSCs移植后的细胞存活,降低了MSCs的修复疗效。在本综述中,我们探讨了MSCs中的铁死亡通路。鉴于目前MSCs中铁死亡的相关研究不足,迫切需要进一步研究,以期提高MSCs在体内的移植修复效率。 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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