JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Inflammatory granuloma of the trachea: a rare case with Epstin-Barr virus infection

Author(s): Zhaodi WANG, Xuan LU, Yunmei YANG, Yuanqiang LU
Affiliation(s): Department of Geriatric and Emergency Medicine, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; more
Corresponding email(s): luyuanqiang@zju.edu.cn
Key Words: Epstein-Barr virus (EBV); Inflammatory granuloma; Metagenomic next-generation sequencing

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Zhaodi WANG, Xuan LU, Yunmei YANG, Yuanqiang LU. Inflammatory granuloma of the trachea: a rare case with Epstin-Barr virus infection[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300024

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year="in press",
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%T Inflammatory granuloma of the trachea: a rare case with Epstin-Barr virus infection
%A Zhaodi WANG
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%J Journal of Zhejiang University SCIENCE B
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A1 - Yuanqiang LU
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PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2300024"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Epstein-Barr virus (EBV), a double-stranded DNA virus with an envelope, is a ubiquitous pathogen that is prevalent in humans, although most people who contract it do not develop symptoms (Kerr, 2019). While the primary cells EBV attacks are epithelial cells and B lymphocytes, its target range expands to a variety of cell types in immunodeficient hosts. Serological change occurs in 90% of infected patients. Therefore, immunoglobulin M (IgM) and IgG, serologically reactive to viral capsid antigens, are reliable biomarkers for the detection of acute and chronic EBV infections (Cohen, 2000). Symptoms of EBV infection vary according to age and immune status. Young patients with primary infection may present with infectious mononucleosis; there is a typical triad of symptoms including fever, angina, and lymphadenectasis (Houen and Trier, 2021). In immunocompromised patients, response after EBV infection may be atypical, with unexplained fever. The nucleic acid of EBV can be detected to confirm whether high-risk patients are infected (Smets et al., 2000). EBV is also associated with the occurrence of certain tumors (such as lymphoma and nasopharyngeal carcinoma) because it transforms host cells (Shannon-Lowe et al., 2017; Tsao et al., 2017).

气管炎性肉芽肿： 1例罕见的EB病毒感染患者

王招娣^1,2，陆璇^1,2，杨云梅^1,2，陆远强^1,2
¹浙江大学医学院附属第一医院老年与急诊医学，中国杭州市，310003
²浙江省增龄与理化损伤性疾病诊治研究重点实验室，中国杭州市，310003
摘要：EB病毒是人类疱疹病毒4型（EBV），其感染可导致不常见的并发症。本文报道的患者气道中出现了与EBV感染相关的炎症性肉芽肿，入院后紧急接受了气管内肿物切除术。他的气道组织经宏基因组下一代测序（mNGS）测试后，被确认为EB病毒感染。在术后第30天，患者接受支气管镜复查时发现声门下方气管壁上出现多个结节性粘膜隆起，且其病理学检查结果发现炎性肉芽组织。因此，推测患者气道内出现的肉芽肿组织可能是由于EB病毒慢性感染导致的。虽然类似的肉芽肿在其他组织中的产生已有报道，但在气道内却是第一次。EB病毒最常通过呼吸道传播，从而入侵上呼吸道的网状内皮细胞，这可能是产生炎性肉芽肿的原因。此外，EB病毒感染后的炎性肉芽肿易复发，需要对患者进行进一步严格的随访。

关键词组：EB病毒；气道肉芽肿；感染；炎症性肉芽肿

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气管炎性肉芽肿： 1例罕见的EB病毒感染患者

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