JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Immune checkpoint blockade for cancer therapy: current progress and perspectives

Author(s): Hongying YE, Weijie LIAO, Jiongli PAN, Yin SHI, Qingqing WANG
Affiliation(s): Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China; more
Corresponding email(s): wqq@zju.edu.cn, yinshi@zju.edu.cn
Key Words: Immune checkpoint blockade; Cancer immunotherapy; Tumor immune evasion; Immune normalization

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Hongying YE, Weijie LIAO, Jiongli PAN, Yin SHI, Qingqing WANG. Immune checkpoint blockade for cancer therapy: current progress and perspectives[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300492

@article{title="Immune checkpoint blockade for cancer therapy: current progress and perspectives",
author="Hongying YE, Weijie LIAO, Jiongli PAN, Yin SHI, Qingqing WANG",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2300492"
}

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%T Immune checkpoint blockade for cancer therapy: current progress and perspectives
%A Hongying YE
%A Weijie LIAO
%A Jiongli PAN
%A Yin SHI
%A Qingqing WANG
%J Journal of Zhejiang University SCIENCE B
%P
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2300492"

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T1 - Immune checkpoint blockade for cancer therapy: current progress and perspectives
A1 - Hongying YE
A1 - Weijie LIAO
A1 - Jiongli PAN
A1 - Yin SHI
A1 - Qingqing WANG
J0 - Journal of Zhejiang University Science B
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%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2300492"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: The dysfunction of anti-tumor immune responses is crucial for cancer progression. Immune checkpoint blockade (ICB), which could potentiate T cell responses, is an effective strategy for the normalization of host anti-tumor immunity. In recent years, immune checkpoints, expressed on both tumor cells and immune cells, have been identified; some of them have exhibited potential druggability and have been approved by the Food and Drug Administration (FDA) for clinical treatments. However, the limited responses and immune-related adverse events (irAEs) cannot be ignored. This review outlines the development and applications of ICBs, potential strategies for overcoming resistance, and future directions for ICB-based cancer immunotherapy.

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