Full Text:  <770>

Summary:  <37>

CLC number: 

On-line Access: 2025-05-28

Received: 2023-12-27

Revision Accepted: 2024-06-15

Crosschecked: 2025-05-29

Cited: 0

Clicked: 934

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Xian LI

https://orcid.org/0000-0001-6380-7336

Ru LUO

https://orcid.org/0000-0001-6877-932X

Xibin XIAO

https://orcid.org/0000-0002-9941-446X

Wenbin QIAN

https://orcid.org/0000-0002-9817-6674

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)


Unmet needs of patients with intravascular large B-cell lymphoma: three case reports and a literature review


Author(s):  Xian LI, Ru LUO, Jiaming XU, Xueli JIN, Weiqin WANG, Xibin XIAO, Wenbin QIAN

Affiliation(s):  Department of Hematology, The Second Affiliated Hospital, School of Medicine, Zhejiang University,Hangzhou310009,China; more

Corresponding email(s):  xiaoxibinzju@zju.edu.cn, qianwb@zju.edu.cn

Key Words:  Intravascular large B-cell lymphoma; Clinicopathologic features; Molecular genetic characteristics; Treatment strategies


Share this article to: More <<< Previous Paper|

Xian LI, Ru LUO, Jiaming XU, Xueli JIN, Weiqin WANG, Xibin XIAO, Wenbin QIAN. Unmet needs of patients with intravascular large B-cell lymphoma: three case reports and a literature review[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300941

@article{title="Unmet needs of patients with intravascular large B-cell lymphoma: three case reports and a literature review",
author="Xian LI, Ru LUO, Jiaming XU, Xueli JIN, Weiqin WANG, Xibin XIAO, Wenbin QIAN",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2300941"
}

%0 Journal Article
%T Unmet needs of patients with intravascular large B-cell lymphoma: three case reports and a literature review
%A Xian LI
%A Ru LUO
%A Jiaming XU
%A Xueli JIN
%A Weiqin WANG
%A Xibin XIAO
%A Wenbin QIAN
%J Journal of Zhejiang University SCIENCE B
%P 493-502
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2300941"

TY - JOUR
T1 - Unmet needs of patients with intravascular large B-cell lymphoma: three case reports and a literature review
A1 - Xian LI
A1 - Ru LUO
A1 - Jiaming XU
A1 - Xueli JIN
A1 - Weiqin WANG
A1 - Xibin XIAO
A1 - Wenbin QIAN
J0 - Journal of Zhejiang University Science B
SP - 493
EP - 502
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
ER -
doi="https://doi.org/10.1631/jzus.B2300941"


Abstract: 
Intravascular large B-cell lymphoma (IVLBCL), a rare subtype of non-Hodgkin lymphoma, is classified as an independent subtype of extranodal diffuse large B-cell lymphoma (DLBCL) in the 2008 World Health Organization (WHO) Classification (Turner et al., 2010). The 5th edition of the World Health Organization (WHO 2022) classification of hematolymphoid tumors retains this subtype (Alaggio et al., 2022). IVLBCL, which is characterized by neoplastic lymphocyte proliferation within the lumen of small blood vessels, tends to invade organs, such as the nervous system, skin, bone marrow (BM), and lung (D'Angelo et al., 2019; Satoh et al., 2019; Vásquez et al., 2019; Fukami et al., 2020).

血管内大B细胞淋巴瘤患者未被满足的需求:3例报告及文献复习

李娴1*,罗茹2*,徐佳鸣3,金雪立1,王炜琴1,肖希斌1,钱文斌1
1浙江大学医学院附属第二医院血液内科,中国杭州市,310009
2浙江大学医学院附属第二医院病理科,中国杭州市,310009
3浙江大学医学院附属第二医院神经外科,中国杭州市,310009
摘要:血管内大B细胞淋巴瘤(IVLBCL)是一种具有高度侵袭性的恶性非霍奇金淋巴瘤,作为结外弥漫大B细胞淋巴瘤(DLBCL)的一种罕见亚型,其特征是小血管腔内的淋巴细胞增殖。IVLBCL早期诊断困难,预后极差。本文介绍了3例IVLBCL患者,分别描述了患者的临床特征和病理特征。所述患者均接受了免疫化疗联合大剂量甲氨蝶呤和布鲁顿酪氨酸激酶抑制剂的综合方案,但疗效有限,仅一名患者获得了良好和持久的反应。本研究回顾了相关文献并进行总结,以进一步识别IVLBCL早期诊断的临床病理特征,并基于分子遗传特征和临床亚型对IVLBCL进行了精确的预后分层,讨论了联合靶向免疫药物的治疗新策略。目前临床上IVLBCL患者的诊断及治疗需求远未被满足,因此我们需要开展更多研究,增加该疾病早期诊断和治疗的可能性,以提高患者生存率。

关键词组:血管内大B细胞淋巴瘤(IVLBCL);临床病理特征;分子遗传学特征;治疗策略

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]AlaggioR,AmadorC,AnagnostopoulosI,et al.,2022.The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms.Leukemia,36(7):1720-1748.

[2]BrunetV,MarouanS,RoutyJP,et al.,2017.Retrospective study of intravascular large B-cell lymphoma cases diagnosed in Quebec: a retrospective study of 29 case reports.Medicine (Baltimore),96(5):e5985.

[3]ChenJM,LuoB,LuoXX,et al.,2021.Clinical subtypes, diagnosis, treatment and prognosis of intravascular large B-cell lymphoma in China.Chin J Oncol Prev Treat,13(3):288-29(in Chinese).

[4]D'AngeloCR,KuK,GulliverJ,et al.,2019.Intravascular large B-cell lymphoma presenting with altered mental status: a case report.World J Clin Oncol,10(12):402-408.

[5]DavisJW,AuerbachA,CrothersBA,et al.,2022.Intravascular large B-cell lymphoma.Arch Pathol Lab Med,146(9):1160-1167.

[6]FerreriAJM,CampoE,AmbrosettiA,et al.,2004a.Anthracycline-based chemotherapy as primary treatment for intravascular lymphoma.Ann Oncol,15(8):1215-1221.

[7]FerreriAJM,CampoE,SeymourJF,et al.,2004b.Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the ‘cutaneous variant’.Br J Haematol,127(2):173-183.

[8]FerreriAJM,DogniniGP,BaireyO,et al.,2008.The addition of rituximab to anthracycline-based chemotherapy significantly improves outcome in ‘Western’ patients with intravascular large B-cell lymphoma.Br J Haematol,143(2):253-257.

[9]FromowitzFB,ViolaMV,ChaoS,et al.,1987.ras p21 expression in the progression of breast cancer.Hum Pathol,18(12):1268-1275.

[10]FukamiY,KoikeH,IijimaM,et al.,2020.Demyelinating neuropathy due to intravascular large B-cell lymphoma.Intern Med,59(3):435-438.

[11]GeerM,RobertsE,ShangoM,et al.,2019.Multicentre retrospective study of intravascular large B-cell lymphoma treated at academic institutions within the United States.Br J Haematol,186(2):255-262.

[12]Gonzalez-FarreB,Ramis-ZaldivarJE,de AntaNC,et al.,2023.Intravascular large B-cell lymphoma genomic profile is characterized by alterations in genes regulating NF-κB and immune checkpoints.Am J Surg Pathol,47(2):202-211.

[13]GuptaGK,JaffeES,PittalugaS,2019.A study of PD-L1 expression in intravascular large B cell lymphoma: correlation with clinical and pathological features.Histopathology,75(2):282-286.

[14]KandaM,SuzumiyaJ,OhshimaK,et al.,2001.Analysis of the immunoglobulin heavy chain gene variable region of intravascular large B-cell lymphoma.Virchows Arch,439(4):540-546.

[15]KatoK,MoriT,KimSW,et al.,2019.Outcome of patients receiving consolidative autologous peripheral blood stem cell transplantation in the frontline treatment of intravascular large B-cell lymphoma: Adult Lymphoma Working Group of the Japan Society for Hematopoietic Cell Transplantation.Bone Marrow Transplant,54(9):1515-1517.

[16]KlairmontMM,ChengJJ,MartinMG,et al.,2018.Recurrent cytogenetic abnormalities in intravascular large B-cell lymphoma.Am J Clin Pathol,150(1):18-26.

[17]LiuZY,ZhangYL,ZhuYC,et al.,2020.Prognosis of intravascular large B cell lymphoma (IVLBCL): analysis of 182 patients from global case series.Cancer Manag Res,12:10531-10540.

[18]LuoCC,YuTT,YoungKH,et al.,2022.HDAC inhibitor chidamide synergizes with venetoclax to inhibit the growth of diffuse large B-cell lymphoma via down-regulation of MYC, BCL2, and TP53 expression.J Zhejiang Univ-Sci B (Biomed & Biotechnol),23(8):666-681.

[19]Lymphoid Disease Group,Chinese Society of Hematology,Chinese Medical Association,et al.,2023.Chinese expert consensus on the diagnosis and management of intravascular large B cell lymphoma (2023).Chin J Hematol,44(3):177-181(in Chinese).

[20]MahadevanD,SpierC,Della CroceK,et al.,2005.Transcript profiling in peripheral T-cell lymphoma, not otherwise specified, and diffuse large B-cell lymphoma identifies distinct tumor profile signatures.Mol Cancer Ther,4(12):1867-1879.

[21]MatsueK,AbeY,NaritaK,et al.,2019.Diagnosis of intravascular large B cell lymphoma: novel insights into clinicopathological features from 42 patients at a single institution over 20 years.Br J Haematol,187(3):328-336.

[22]MeissnerJ,FinelH,DietrichS,et al.,2017.Autologous hematopoietic stem cell transplantation for intravascular large B-cell lymphoma: the European Society for Blood and Marrow Transplantation experience.Bone Marrow Transplant,52(4):650-652.

[23]MuftahS,XuZD,el GaddafiW,et al.,2012.Synchronous intravascular large B-cell lymphoma within meningioma.Neuropathology,32(1):77-81.

[24]MuraseT,NakamuraS,KawauchiK,et al.,2000.An Asian variant of intravascular large B-cell lymphoma: clinical, pathological and cytogenetic approaches to diffuse large B-cell lymphoma associated with haemophagocytic syndrome.Br J Haematol,111(3):826-834.

[25]MuraseT,YamaguchiM,SuzukiR,et al.,2007.Intravascular large B-cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5.Blood,109(2):478-485.

[26]PolettoS,NovoM,ParuzzoL,et al.,2022.Treatment strategies for patients with diffuse large B-cell lymphoma.Cancer Treat Rev,110:102443.

[27]PonzoniM,FerreriAJM,CampoE,et al.,2007.Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting.J Clin Oncol,25(21):3168-3173.

[28]PonzoniM,CampoE,NakamuraS,2018.Intravascular large B-cell lymphoma: a chameleon with multiple faces and many masks.Blood,132(15):1561-1567.

[29]QiuLQ,WangSA,VegaF,et al.,2022.From the archives of MD Anderson Cancer Center: intravascular large B-cell lymphoma with numerous circulating lymphoma cells.Ann Diagn Pathol,58:151934.

[30]RajyaguruDJ,BhaskarC,BorgertAJ,et al.,2017.Intravascular large B-cell lymphoma in the United States (US): a population-based study using surveillance, epidemiology, and end results program and national cancer database.Leuk Lymphoma,58(9):2080-2088.

[31]SakakibaraA,InagakiY,ImaokaE,et al.,2018.Autopsy case report of intravascular large B-cell lymphoma with neoplastic PD-L1 expression.J Clin Exp Hematop,58(1):32-35.

[32]SatohT,AraiE,KayanoH,et al.,2019.Pulmonary intravascular large B-cell lymphoma accompanying synchronous primary pulmonary adenocarcinoma and benign interstitial lesions.J Clin Exp Hematop,59(3):140-144.

[33]SchmitzR,WrightGW,HuangDW,et al.,2018.Genetics and pathogenesis of diffuse large B-Cell lymphoma.N Engl J Med,378(15):1396-1407.

[34]ShimadaK,MatsueK,YamamotoK,et al.,2008.Retrospective analysis of intravascular large B-cell lymphoma treated with rituximab-containing chemotherapy as reported by the IVL study group in Japan.J Clin Oncol,26(19):3189-3195.

[35]ShimadaK,MuraseT,MatsueK,et al.,2010.Central nervous system involvement in intravascular large B-cell lymphoma: a retrospective analysis of 109 patients.Cancer Sci,101(6):1480-1486.

[36]ShimadaK,YamaguchiM,AtsutaY,et al.,2020.Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone combined with high-dose methotrexate plus intrathecal chemotherapy for newly diagnosed intravascular large B-cell lymphoma (PRIMEUR-IVL): a multicentre, single-arm, phase 2 trial.Lancet Oncol,21(4):593-602.

[37]ShimadaK,YoshidaK,SuzukiY,et al.,2021.Frequent genetic alterations in immune checkpoint‒related genes in intravascular large B-cell lymphoma. Blood,137(11):1491-1502.

[38]TakahashiH,NishimakiH,NakanishiY,et al.,2022.Clinical impact of central nervous system-directed therapies on intravascular large B-cell lymphoma: a single institution’s experience.EJHaem,3(2):467-470.

[39]TurnerJJ,MortonLM,LinetMS,et al.,2010.InterLymph hierarchical classification of lymphoid neoplasms for epidemiologic research based on the WHO classification (2008): update and future directions.Blood,116(20):e90-e98.

[40]VásquezJ,RomeroV,VilasP,et al.,2019.Progressive edemas and generalized telangiectasia: a presentation of intravascular B-cell lymphoma.Clin Case Rep,7(12):2429-2432.

[41]VieitesB,FragaM,López-PresasE,et al.,2005.Detection of t(14;18) translocation in a case of intravascular large B-cell lymphoma: a germinal centre cell origin in a subset of these lymphomas?Histopathology,46(4):466-468.

[42]Xu-MonetteZY,TuMF,JabbarKJ,et al.,2015.Clinical and biological significance ofde novo CD5+ diffuse large B-cell lymphoma in Western countries.Oncotarget,6(8):5615-5633.

[43]YegappanS,CouplandR,ArberDA,et al.,2001.Angiotropic lymphoma: an immunophenotypically and clinically heterogeneous lymphoma.Mod Pathol,14(11):1147-1156.

[44]YuanYY,WangEH,WangL,2022.The first case of a collision tumor of gastrointestinal stromal tumor and intravascular large B cell lymphoma.Ann Hematol,101(1):233-235.

[45]ZhangF,LuoXL,ChenY,et al.,2015.Intravascular large B-cell lymphoma involving gastrointestinal stromal tumor: a case report and literature review.Diagn Pathol,10:214.

[46]ZhangY,ChenC,ZhaoDQ,et al.,2023.P1185: a prospective single-center phase 2 study of zanubrutinib plus R-CHOP in treat-naïve intravascular large B cell lymphoma.HemaSphere, 7(Sl):e1662573.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2025 Journal of Zhejiang University-SCIENCE