JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Cellulose nanofibril matrix drives the dynamic formation of spheroids

Author(s): Yi LU, Guo LI, Yeqiu LI, Yuan YAO
Affiliation(s): College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang, 310027, China; more
Corresponding email(s): yyao1@zju.edu.cn
Key Words: Cellulose; Nanofibril; Matrix; Self-Assembly; Spheroid

Share this article to： More <<< Previous Paper \|Next Paper >>>

Yi LU, Guo LI, Yeqiu LI, Yuan YAO. Cellulose nanofibril matrix drives the dynamic formation of spheroids[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B23Z0003

@article{title="Cellulose nanofibril matrix drives the dynamic formation of spheroids",
author="Yi LU, Guo LI, Yeqiu LI, Yuan YAO",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B23Z0003"
}

%0 Journal Article
%T Cellulose nanofibril matrix drives the dynamic formation of spheroids
%A Yi LU
%A Guo LI
%A Yeqiu LI
%A Yuan YAO
%J Journal of Zhejiang University SCIENCE B
%P
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B23Z0003"

TY - JOUR
T1 - Cellulose nanofibril matrix drives the dynamic formation of spheroids
A1 - Yi LU
A1 - Guo LI
A1 - Yeqiu LI
A1 - Yuan YAO
J0 - Journal of Zhejiang University Science B
SP -
EP -
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
ER -
doi="https://doi.org/10.1631/jzus.B23Z0003"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Multicellular spheroids, which mimic the natural organ counterparts, allow the prospect of drug screening and regenerative medicine. However, their application is hampered by low processing efficiency or limited scale. This study introduces an efficient method to drive rapid multicellular spheroid formation by a cellulose nanofibril matrix. This matrix enables the facilitated growth of spheroids (within 48 hours) through multiple cell assembly into size-controllable aggregates with well-organized physiological microstructure. The efficiency, dimension, and conformation of the as-formed spheroids depend on the concentration of extracellular nanofibrils, the number of assembled cells, and the heterogeneity of cell types. The above strategy allows the robust formation mechanism of compacted tumoroids and hepatocyte spheroids.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

Open peer comments: Debate/Discuss/Question/Opinion

<1>

- Go to

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference