JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Deciphering odontogenic myxoma: The role of copy number variations as diagnostic signatures

Author(s): Aobo ZHANG, Jianyun ZHANG, Xuefen LI, Xia ZHOU, Yanrui FENG, Lijing ZHU, Heyu ZHANG, Lisha SUN, Tiejun LI
Affiliation(s): Department of Oral Pathology, Peking University School and Hospital of Stomatology & more
Corresponding email(s): litiejun22@vip.sina.com, lisa_sun@bjmu.edu.cn, zhangheyu1983@sina.cn
Key Words: Odontogenic myxoma; Copy number variation; Odontogenic fibroma; Odontogenic fibromyxoma; Diagnostic marker.

Share this article to： More <<< Previous Paper \|Next Paper >>>

Aobo ZHANG, Jianyun ZHANG, Xuefen LI, Xia ZHOU, Yanrui FENG, Lijing ZHU, Heyu ZHANG, Lisha SUN, Tiejun LI. Deciphering odontogenic myxoma: The role of copy number variations as diagnostic signatures[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2400081

@article{title="Deciphering odontogenic myxoma: The role of copy number variations as diagnostic signatures",
author="Aobo ZHANG, Jianyun ZHANG, Xuefen LI, Xia ZHOU, Yanrui FENG, Lijing ZHU, Heyu ZHANG, Lisha SUN, Tiejun LI",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2400081"
}

%0 Journal Article
%T Deciphering odontogenic myxoma: The role of copy number variations as diagnostic signatures
%A Aobo ZHANG
%A Jianyun ZHANG
%A Xuefen LI
%A Xia ZHOU
%A Yanrui FENG
%A Lijing ZHU
%A Heyu ZHANG
%A Lisha SUN
%A Tiejun LI
%J Journal of Zhejiang University SCIENCE B
%P
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2400081"

TY - JOUR
T1 - Deciphering odontogenic myxoma: The role of copy number variations as diagnostic signatures
A1 - Aobo ZHANG
A1 - Jianyun ZHANG
A1 - Xuefen LI
A1 - Xia ZHOU
A1 - Yanrui FENG
A1 - Lijing ZHU
A1 - Heyu ZHANG
A1 - Lisha SUN
A1 - Tiejun LI
J0 - Journal of Zhejiang University Science B
SP -
EP -
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
ER -
doi="https://doi.org/10.1631/jzus.B2400081"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: In light of the lack of reliable molecular markers for odontogenic myxoma (OM), the detection of copy number variations (CNV) may present a more objective method for assessing ambiguous cases. In this study, we employed multiregional microdissection sequencing to integrate morphological features with genomic profiling. This allowed us to reveal the CNV profiles of OM and compare them with dental papilla (DP), dental follicle (DF), and odontogenic fibroma (OF) tissues. We identified a distinct and robustly consistent CNV pattern in 93.75% (30/32) of OM cases, characterized by CNV gain events in chromosomes 4, 5, 8, 10, 12, 16, 17, 20 and 21. This pattern significantly differed from the CNV patterns observed in DP, DF, and OF. KEGG analysis indicated potential links between this CNV patterns and the calcium signaling pathway and salivary secretion, while GO term analysis implicated CNV patterns in tumor adhesion, tooth development, and cell proliferation. Comprehensive CNV analysis accurately identified a case that was initially disputable between OF and OM as OM. Our findings provide a reliable diagnostic clue and fresh insights into the molecular biological mechanism underlying OM.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

Open peer comments: Debate/Discuss/Question/Opinion

<1>

- Go to

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference