JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

PICK1 modulates proliferation and migration of gastric cancer cells via regulating TLR4

Author(s): Kaiqiang LI, Yimin YANG, Yaling WANG, Jing JIN, Qianni WANG, Lina PENG, Aibo XU, Xuling LUO, Wei YANG, Peng XU, Bingyu CHEN, Ke HAO, Zhen WANG
Affiliation(s): Laboratory Medicine Center, Allergy center, Department of Transfusion Medicine, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou 310014, China; more
Corresponding email(s): wangzhen@hmc.edu.cn, haoke@hmc.edu.cn, chenbingyu@hmc.edu.cn
Key Words: Protein interacting with C kinase 1; Gastric cancer; Toll-like receptor 4; MYD88 signalling pathway; Autophagy

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Kaiqiang LI, Yimin YANG, Yaling WANG, Jing JIN, Qianni WANG, Lina PENG, Aibo XU, Xuling LUO, Wei YANG, Peng XU, Bingyu CHEN, Ke HAO, Zhen WANG. PICK1 modulates proliferation and migration of gastric cancer cells via regulating TLR4[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2400167

@article{title="PICK1 modulates proliferation and migration of gastric cancer cells via regulating TLR4",
author="Kaiqiang LI, Yimin YANG, Yaling WANG, Jing JIN, Qianni WANG, Lina PENG, Aibo XU, Xuling LUO, Wei YANG, Peng XU, Bingyu CHEN, Ke HAO, Zhen WANG",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2400167"
}

%0 Journal Article
%T PICK1 modulates proliferation and migration of gastric cancer cells via regulating TLR4
%A Kaiqiang LI
%A Yimin YANG
%A Yaling WANG
%A Jing JIN
%A Qianni WANG
%A Lina PENG
%A Aibo XU
%A Xuling LUO
%A Wei YANG
%A Peng XU
%A Bingyu CHEN
%A Ke HAO
%A Zhen WANG
%J Journal of Zhejiang University SCIENCE B
%P
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2400167"

TY - JOUR
T1 - PICK1 modulates proliferation and migration of gastric cancer cells via regulating TLR4
A1 - Kaiqiang LI
A1 - Yimin YANG
A1 - Yaling WANG
A1 - Jing JIN
A1 - Qianni WANG
A1 - Lina PENG
A1 - Aibo XU
A1 - Xuling LUO
A1 - Wei YANG
A1 - Peng XU
A1 - Bingyu CHEN
A1 - Ke HAO
A1 - Zhen WANG
J0 - Journal of Zhejiang University Science B
SP -
EP -
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2400167"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Protein interacting with C kinase 1 (PICK1) interacts with a variety of membrane proteins and receptors involved in nervous system diseases and multiple cancers. However, the role of PICK1 in gastric cancer remains unclear. In the present work, we explored the expression and interactions of PICK1 with Toll-like receptor 4 (TLR4) in gastric cancer. Clinical data analysis showed that PICK1 expression decreases and is predictive of worse outcomes in patients with gastric cancer. High PICK1 levels attenuated the proliferation and migration of gastric cancer cells, which is dependent on the TLR4/MYD88 signaling pathway. Furthermore, in vitro experiments demonstrated that PICK1 affects the trafficking and degradation of TLR4 and promotes TLR4 degradation via autophagy in gastric cancer cells. Molecular dynamics simulations highlighted the binding strength and stability of the TLR4-PICK1 complex. Our study provides new insights into the cellular and pathological functions of PICK1 in gastric cancer.

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