JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect related diseases

Author(s): Xiaodan HUANG, Yue FANG, Jie SONG, Yuanjing HAO, Yuanyuan CAI, Pengfei WEI, Na ZHANG
Affiliation(s): School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, China; more
Corresponding email(s): pfwei@bzmc.edu.cn, zhangna20@bzmc.edu.cn
Key Words: Lysosome; Autophagy; Lysosomal/autophagic disfunction; Acidic nanoparticles; Transcription factor EB; Dementia; Alzheimer’s disease

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Xiaodan HUANG, Yue FANG, Jie SONG, Yuanjing HAO, Yuanyuan CAI, Pengfei WEI, Na ZHANG. Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect related diseases[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2400186

@article{title="Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect related diseases",
author="Xiaodan HUANG, Yue FANG, Jie SONG, Yuanjing HAO, Yuanyuan CAI, Pengfei WEI, Na ZHANG",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2400186"
}

%0 Journal Article
%T Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect related diseases
%A Xiaodan HUANG
%A Yue FANG
%A Jie SONG
%A Yuanjing HAO
%A Yuanyuan CAI
%A Pengfei WEI
%A Na ZHANG
%J Journal of Zhejiang University SCIENCE B
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%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2400186"

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T1 - Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect related diseases
A1 - Xiaodan HUANG
A1 - Yue FANG
A1 - Jie SONG
A1 - Yuanjing HAO
A1 - Yuanyuan CAI
A1 - Pengfei WEI
A1 - Na ZHANG
J0 - Journal of Zhejiang University Science B
SP -
EP -
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2400186"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: The dysfunction of the lysosome and autophagy-lysosome system serves as a driving force for neurodegenerative diseases, metabolic disorders, inflammatory conditions, and other related diseases, closely influencing their onset and progression. Therefore, restoring the function of the lysosome or autophagy-lysosome system has become an increasingly crucial therapeutic strategy in disease management. In this article, we introduce lysosomal biogenesis, structure, and function, as well as the biological process of the autophagy–lysosome system. Various diseases closely associated with lysosomal/autophagic dysfunction are also reviewed, emphasizing the significance of regulating the function of the lysosome or autophagy-lysosome system in disease treatment. Finally, we focus on engineered nanomaterials that have the capabilities to restore the function of the lysosome or autophagy-lysosome system, and summarize different strategies and methods for achieving this goal. This review article aims to elucidate the latest progress in the field of nanomedicine for lysosomal/autophagic defect-related diseases and inspire the development of innovative and clinically valuable nanomedicines.

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