Full Text:  <263>

CLC number: 

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 0000-00-00

Cited: 0

Clicked: 437

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)


CXCL16 promotes proliferation of head and neck squamous cell carcinoma by regulating GPX1-mediated antioxidant levels


Author(s):  Ru HE, Hongyi JIANG, Chengchi ZHANG, Yuan CHEN, Wenshun LIU, Xinyue DENG, Xiaozheng ZHU, Yunye LIU, Chuanming ZHENG, Yining ZHANG, Chengying SHAO, Yanting DUAN, Jiajie XU

Affiliation(s):  Otolaryngology & more

Corresponding email(s):  dyt19880818@163.com, xujiajie@hmc.edu.cn

Key Words:  Antioxidant pathway; CXC motif chemokine ligand 16 (CXCL16); Glutathione peroxidase 1 (GPX1); Head and neck squamous cell carcinoma


Share this article to: More <<< Previous Paper|Next Paper >>>

Ru HE, Hongyi JIANG, Chengchi ZHANG, Yuan CHEN, Wenshun LIU, Xinyue DENG, Xiaozheng ZHU, Yunye LIU, Chuanming ZHENG, Yining ZHANG, Chengying SHAO, Yanting DUAN, Jiajie XU. CXCL16 promotes proliferation of head and neck squamous cell carcinoma by regulating GPX1-mediated antioxidant levels[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2400192

@article{title="CXCL16 promotes proliferation of head and neck squamous cell carcinoma by regulating GPX1-mediated antioxidant levels",
author="Ru HE, Hongyi JIANG, Chengchi ZHANG, Yuan CHEN, Wenshun LIU, Xinyue DENG, Xiaozheng ZHU, Yunye LIU, Chuanming ZHENG, Yining ZHANG, Chengying SHAO, Yanting DUAN, Jiajie XU",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2400192"
}

%0 Journal Article
%T CXCL16 promotes proliferation of head and neck squamous cell carcinoma by regulating GPX1-mediated antioxidant levels
%A Ru HE
%A Hongyi JIANG
%A Chengchi ZHANG
%A Yuan CHEN
%A Wenshun LIU
%A Xinyue DENG
%A Xiaozheng ZHU
%A Yunye LIU
%A Chuanming ZHENG
%A Yining ZHANG
%A Chengying SHAO
%A Yanting DUAN
%A Jiajie XU
%J Journal of Zhejiang University SCIENCE B
%P
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2400192"

TY - JOUR
T1 - CXCL16 promotes proliferation of head and neck squamous cell carcinoma by regulating GPX1-mediated antioxidant levels
A1 - Ru HE
A1 - Hongyi JIANG
A1 - Chengchi ZHANG
A1 - Yuan CHEN
A1 - Wenshun LIU
A1 - Xinyue DENG
A1 - Xiaozheng ZHU
A1 - Yunye LIU
A1 - Chuanming ZHENG
A1 - Yining ZHANG
A1 - Chengying SHAO
A1 - Yanting DUAN
A1 - Jiajie XU
J0 - Journal of Zhejiang University Science B
SP -
EP -
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
ER -
doi="https://doi.org/10.1631/jzus.B2400192"


Abstract: 
Numerous studies have demonstrated that high expression of the CXC motif chemokine ligand 16 (CXCL16) in cancer correlates with poor prognosis, as well as tumor cell proliferation, migration and invasion. While CXCL16 can serve as a tumor biomarker, the underlying mechanism in modulating head and neck squamous carcinoma (HNSCC) remains unclear. In this study, we aimed to investigate CXCL16 expression in head and neck squamous carcinoma and uncover the potential underlying mechanism. We determined the high expression of CXCL16 in The Cancer Genome Atlas (TCGA) database, tissue samples from patients with head and neck squamous cell carcinoma at our central hospital and from HNSCC cell lines. The results showed that CXCL16 knockdown inhibited the proliferation, migration and invasion of HNSCC cells. Mechanistically, transcriptome sequencing revealed that CXCL16 may affect HNSCC cell growth by regulating the antioxidant pathway of glutathione peroxidase 1 (GPX1). ROS levels were elevated in si-CXCL16 cells, which may contribute to the inhibition of cell proliferation, migration and invasion. Moreover, treatment of cells with the GPX1 inhibitor eldecalcitol (ED-71) revealed that HNSCC cell growth was significantly inhibited in the synergistic group of si-CXCL16 and GPX1 inhibitor compared to the si-CXCL16 group. In conclusion, CXCL16 contributed to the development of HNSCC cells by modulating the GPX1-mediated antioxidant pathway. Thus, targeting cellular CXCL16 expression seems a promising strategy for treating head and neck squamous cell carcinoma.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE