JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Cell proliferation and differentiation during epidermis renewal

Author(s): Kai LIU^1, ², Kaidi REN³, Dengwen LI², Yang YANG¹
Affiliation(s): ¹Department of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; more
Corresponding email(s): renkd006@163.com, dwli@nankai.edu.cn
Key Words: Epidermis renewal; Stem cell proliferation; Asymmetric cell division; Basement membrane dynamics; Single-cell omics; Mechanotransduction

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Kai LIU^1,², Kaidi REN³, Dengwen LI², Yang YANG¹. Cell proliferation and differentiation during epidermis renewal[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2500085

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author="Kai LIU^1,², Kaidi REN³, Dengwen LI², Yang YANG¹",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2500085"
}

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%A Yang YANG¹
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doi="https://doi.org/10.1631/jzus.B2500085"

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A1 - Yang YANG¹
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doi="https://doi.org/10.1631/jzus.B2500085"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Residing at the outermost layer of the skin, the epidermis is composed of stratified squamous epithelial cells. Regular renewal of the epidermis is essential for maintaining its barrier function, which is dependent on the orchestrated proliferation and differentiation of stem cells located in the basal epidermis. This process necessitates precise dual regulation through the intrinsic control of cell division orientation and external microenvironmental influences. In this comprehensive review, we delve into the critical processes underlying epidermis renewal, emphasizing the balance between symmetric and asymmetric cell fate and the integration of differentiated cells into the suprabasal layer. Our paper highlights the pivotal roles of single-cell omics, live imaging and artificial intelligence (AI)-driven modeling techniques in elucidating the molecular mechanisms governing cell proliferation and differentiation during epidermis renewal.

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