JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

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Tackling iron deficiency: the multifunctional benefits of biopolysaccharide-iron(III) complexes from traditional Chinese medicinal plants

Author(s): Wenyang ZHAO^1, ², Chun-Wai MAI³, Kai Bin LIEW⁴, Siew-Keah LEE⁵, Wei DU⁶, Li CHEN⁷, Gabriel Akyirem AKOWUAH⁸, Yik-Ling CHEW¹
Affiliation(s): ¹Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia; more
Corresponding email(s): chew.yikling@gmail.com
Key Words: Traditional Chinese Medicine; Polysaccharides; Iron complex; Iron deficiency anaemia; Drug delivery

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Wenyang ZHAO^1,², Chun-Wai MAI³, Kai Bin LIEW⁴, Siew-Keah LEE⁵, Wei DU⁶, Li CHEN⁷, Gabriel Akyirem AKOWUAH⁸, Yik-Ling CHEW¹. Tackling iron deficiency: the multifunctional benefits of biopolysaccharide-iron(III) complexes from traditional Chinese medicinal plants[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2500114

@article{title="Tackling iron deficiency: the multifunctional benefits of biopolysaccharide-iron(III) complexes from traditional Chinese medicinal plants",
author="Wenyang ZHAO^1,², Chun-Wai MAI³, Kai Bin LIEW⁴, Siew-Keah LEE⁵, Wei DU⁶, Li CHEN⁷, Gabriel Akyirem AKOWUAH⁸, Yik-Ling CHEW¹",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2500114"
}

%0 Journal Article
%T Tackling iron deficiency: the multifunctional benefits of biopolysaccharide-iron(III) complexes from traditional Chinese medicinal plants
%A Wenyang ZHAO^1
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%A Chun-Wai MAI³
%A Kai Bin LIEW⁴
%A Siew-Keah LEE⁵
%A Wei DU⁶
%A Li CHEN⁷
%A Gabriel Akyirem AKOWUAH⁸
%A Yik-Ling CHEW¹
%J Journal of Zhejiang University SCIENCE B
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%@ 1673-1581
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%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2500114"

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T1 - Tackling iron deficiency: the multifunctional benefits of biopolysaccharide-iron(III) complexes from traditional Chinese medicinal plants
A1 - Wenyang ZHAO^{1
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A1 - Chun-Wai MAI³
A1 - Kai Bin LIEW⁴
A1 - Siew-Keah LEE⁵
A1 - Wei DU⁶
A1 - Li CHEN⁷
A1 - Gabriel Akyirem AKOWUAH⁸
A1 - Yik-Ling CHEW¹
J0 - Journal of Zhejiang University Science B
SP -
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%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2500114"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Traditional Chinese Medicinal (TCM) plants are known to contain bioactive ingredients, including beneficial biopolysaccharides that may also serve as excipients in drug formulation and delivery. Some of these biopolysaccharides also exhibit a wide range of biological activities. Biopolysaccharides have also been used in the development of biopolysaccharide-iron complexes that are characterized by high iron content, low gastrointestinal irritation and enhanced bioavailability, helping to overcome the limitations of conventional iron supplements. This review focuses on the unique properties of TCM-derived biopolysaccharides in addressing these limitations and highlights their bioavailability and therapeutic potential, including their roles in iron release and delivery, gastroprotective effects, blood sugar regulation, and antioxidant activity, as demonstrated in in vitro and in vivo experiments and clinical trials. The adverse reactions, safety profile and structure–activity relationship of biopolysaccharide-iron complexes in antioxidant activities are also thoroughly discussed. Supplementation with these next-generation iron complexes may represent a promising strategy for the treatment of iron deficiency anaemia and the promotion of overall human health and well-being.

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