JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Protective effect of medium-chain monoglycerides on hepatic lipid accumulation via modulation of bile acid metabolism in Dongliao black pigs

Author(s): Nanhai XIAO¹, Xutang WANG², Jing WANG^1, ³, Fengqin FENG^1, ⁴, Minjie ZHAO¹
Affiliation(s): ¹College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China ²Hangzhou Longyu Biotechnology Co., Ltd, Hangzhou 310003, China ³Ningbo Research Institute, Zhejiang University, Ningbo 315100, China ⁴ZhongYuan Institute, Zhejiang University, Zhengzhou 450001, China
Corresponding email(s): Minjie ZHAO, minjiezhao@zju.edu.cn
Key Words: Medium chain monoglyceride; Transcriptome; Bile acid; Cholesterol; Gut microbiota

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Nanhai XIAO¹, Xutang WANG², Jing WANG^1,³, Fengqin FENG^1,⁴, Minjie ZHAO¹. Protective effect of medium-chain monoglycerides on hepatic lipid accumulation via modulation of bile acid metabolism in Dongliao black pigs[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2500239

@article{title="Protective effect of medium-chain monoglycerides on hepatic lipid accumulation via modulation of bile acid metabolism in Dongliao black pigs",
author="Nanhai XIAO¹, Xutang WANG², Jing WANG^1,³, Fengqin FENG^1,⁴, Minjie ZHAO¹",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2500239"
}

%0 Journal Article
%T Protective effect of medium-chain monoglycerides on hepatic lipid accumulation via modulation of bile acid metabolism in Dongliao black pigs
%A Nanhai XIAO¹
%A Xutang WANG²
%A Jing WANG^1
%A³
%A Fengqin FENG^1
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%A Minjie ZHAO¹
%J Journal of Zhejiang University SCIENCE B
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%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2500239"

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T1 - Protective effect of medium-chain monoglycerides on hepatic lipid accumulation via modulation of bile acid metabolism in Dongliao black pigs
A1 - Nanhai XIAO¹
A1 - Xutang WANG²
A1 - Jing WANG^{1
A1 -}³
A1 - Fengqin FENG^{1
A1 -}⁴
A1 - Minjie ZHAO¹
J0 - Journal of Zhejiang University Science B
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PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2500239"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: The aim of this study was to investigate the effects of feed supplementation with medium-chain monoglycerides (MG) on the growth performance, serum biochemistry, hepatic health, and gut microbiota of Dongliao black pigs. The results showed that 750 mg/kg of MG significantly increased body weight and slaughter rate, while it decreased feed conversion ratio and backfat thickness. In range of 250 mg/kg to 1000 mg/kg MG, there were no significant influences on glucolipid metabolism, the biomarkers of liver and kidney function, and appetite hormones in the serum. However, the control group exhibited massive hepatic lipid deposition, whereas this phenomenon was significantly alleviated after 750 mg/kg of MG intervention. The transcriptome results showed that 750 mg/kg of MG significantly increased the expression of genes related to cholesterol synthesis, cholesterol to bile acid conversion, bile acid glucuronidation, and bile acid reabsorption. Meanwhile, 750 mg/kg of MG prominently enhanced the concentration of total bile acid in the liver and feces. In brief, MG promoted the growth performance and improved the hepatic health of black pigs via the regulation of bile acid metabolism, therefore it has the potential to be used as a feed additive in finishing pigs, with an optimal dietary MG requirement of 750 mg/kg.

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