JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

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Novel multi-component synergistic bioink that balances biocompatibility and mechanical strength for cartilage regeneration

Author(s): Zijun MA¹, Wendan JIA¹, Xiaoyuan WANG¹, Rong CHENG¹, Lu HAN¹, Meng LI¹, Xiaoning YANG³, Shengbo SANG^1, ²
Affiliation(s): ¹Shanxi Key Laboratory of Artificial Intelligence & Micro Nano Sensors, College of Integrated Circuits, Taiyuan University of Technology, Taiyuan 030024, China ²Key Lab of Advanced Transducers and Intelligent Control System of the Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, China ³Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering, Taiyuan 030024, China
Corresponding email(s): Meng LI, mengli_1217@163.com, Xiangning YANG, xnyang@pku.edu.cn, Shengbo SANG, sunboa-sang@tyut.edu.cn
Key Words: Silk fibroin; Polyethylene oxide; Multi component collaboration; Cartilage regeneration; Tissue engineering

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Zijun MA¹, Wendan JIA¹, Xiaoyuan WANG¹, Rong CHENG¹, Lu HAN¹, Meng LI¹, Xiaoning YANG³,Shengbo SANG^1,². Novel multi-component synergistic bioink that balances biocompatibility and mechanical strength for cartilage regeneration[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2500343

@article{title="Novel multi-component synergistic bioink that balances biocompatibility and mechanical strength for cartilage regeneration",
author="Zijun MA¹, Wendan JIA¹, Xiaoyuan WANG¹, Rong CHENG¹, Lu HAN¹, Meng LI¹, Xiaoning YANG³,Shengbo SANG^1,²",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2500343"
}

%0 Journal Article
%T Novel multi-component synergistic bioink that balances biocompatibility and mechanical strength for cartilage regeneration
%A Zijun MA¹
%A Wendan JIA¹
%A Xiaoyuan WANG¹
%A Rong CHENG¹
%A Lu HAN¹
%A Meng LI¹
%A Xiaoning YANG³
%A Shengbo SANG^1
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%J Journal of Zhejiang University SCIENCE B
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doi="https://doi.org/10.1631/jzus.B2500343"

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T1 - Novel multi-component synergistic bioink that balances biocompatibility and mechanical strength for cartilage regeneration
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A1 - Wendan JIA¹
A1 - Xiaoyuan WANG¹
A1 - Rong CHENG¹
A1 - Lu HAN¹
A1 - Meng LI¹
A1 - Xiaoning YANG³
A1 - Shengbo SANG^{1
A1 -}²
J0 - Journal of Zhejiang University Science B
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%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2500343"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Hydrogels, owing to their porous network structure resembling the extracellular matrix (ECM), have become essential scaffold materials in the field of cartilage tissue engineering. Among them, gelatin methacrylate (GelMA) hydrogels are widely used in bioink development due to their excellent biocompatibility, biodegradability and tunable photo crosslinking properties. However, the high biocompatibility of pure GelMA often comes at the cost of mechanical strength, limiting its applicability in cartilage regeneration. To overcome this trade-off, this study developed composite bioinks based on GelMA, silk fibroin (SF) and polyethylene oxide (PEO) for fabricating porous hydrogel scaffolds, which were then systematically characterized in terms of morphology, porosity, hydrophilicity, mechanical strength, rheological behavior, printability, and cytocompatibility. In this design, PEO serves as a porogen to generate highly porous structures (porosity up to 88%), while SF compensates for the mechanical loss caused by PEO, enabling the scaffold to retain a compression strength of up to 29.10?kPa. Among the tested formulations, the 10% GelMA/1% SF/1.5% (1%=0.01 g/mL) PEO bioink exhibited excellent printability, mechanical integrity and cytocompatibility, and it supported a robust deposition of collagen II and aggrecan by chondrocytes after printing. This work provides a versatile strategy for balancing the biocompatibility and mechanical robustness in bioinks, offering a promising platform for next-generation cartilage tissue engineering scaffolds.

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