JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

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SWCNTs/PEDOT:PSS-modified microelectrode arrays reveal striatal-hippocampal neural encoding of movement initiation and place fields during goal-directed navigation

Author(s): Jin SHAN^1, ², Wei XU^1, ², Jinping LUO^1, ², Yaoyao LIU^1, ², Ming LI^1, ², Luyi JING^1, ², Yu WANG^1, ², Shiya LV^1, ², Zhaojie XU^1, ², Juntao LIU^1, ², Yiming DUAN^1, ², Qianli JIA^1, ², Yilin SONG^1, ², Mixia WANG^1, ², Xinxia CAI^1, ²
Affiliation(s): ¹State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China ²School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
Corresponding email(s): Xinxia CAI, xxcai@mail.ie.ac.cn Yilin SONG, ylsong@mail.ie.ac.cn Mixia WANG, wangmixia@mail.ie.ac.cn
Key Words: Microelectrode array; SWCNTs/PEDOT:PSS; Electrophysiology; Navigation

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Jin SHAN^1,², Wei XU^1,², Jinping LUO^1,², Yaoyao LIU^1,², Ming LI^1,², Luyi JING^1,², Yu WANG^1,², Shiya LV^1,², Zhaojie XU^1,², Juntao LIU^1,², Yiming DUAN^1,², Qianli JIA^1,², Yilin SONG^1,², Mixia WANG^1,², Xinxia CAI^1,². SWCNTs/PEDOT:PSS-modified microelectrode arrays reveal striatal-hippocampal neural encoding of movement initiation and place fields during goal-directed navigation[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2500462

@article{title="SWCNTs/PEDOT:PSS-modified microelectrode arrays reveal striatal-hippocampal neural encoding of movement initiation and place fields during goal-directed navigation",
author="Jin SHAN^1,², Wei XU^1,², Jinping LUO^1,², Yaoyao LIU^1,², Ming LI^1,², Luyi JING^1,², Yu WANG^1,², Shiya LV^1,², Zhaojie XU^1,², Juntao LIU^1,², Yiming DUAN^1,², Qianli JIA^1,², Yilin SONG^1,², Mixia WANG^1,², Xinxia CAI^1,²",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2500462"
}

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%A Yaoyao LIU^1
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%A Luyi JING^1
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%A Yu WANG^1
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%A Shiya LV^1
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%A Zhaojie XU^1
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%A Juntao LIU^1
%A²
%A Yiming DUAN^1
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%A Yilin SONG^1
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%A Mixia WANG^1
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%A Xinxia CAI^1
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%J Journal of Zhejiang University SCIENCE B
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doi="https://doi.org/10.1631/jzus.B2500462"

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doi="https://doi.org/10.1631/jzus.B2500462"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Goal-directed navigation necessitates coordinated interactions among multiple brain regions, with the hippocampus and striatum playing critical roles in spatial representation, movement-related information, and reward-related evaluation. The hippocampus, particularly the CA1 (Cornu Ammonis 1) region, is renowned for its role in spatial encoding via place cells. The striatum, a basal ganglia nucleus, can integrate cortical, thalamic, and limbic inputs to regulate motor planning, reward valuation, and behavioral flexibility. Despite extensive research, a key challenge remains: the lack of high spatiotemporal resolution, high-precision, and multi-channel electrodes that are structurally matched for reliable implantation across multiple brain regions. To address this, we developed two silicon-based microelectrode arrays (MEAs) anatomically tailored for dual-region neuronal electrophysiological recording of the striatum and CA1. By modifying the electrode sites with SWCNTs/PEDOT:PSS nanocomposites, we significantly enhanced the electrical performance, reducing impedance and phase delay. Leveraging this platform, we demonstrated that neurons in the rat ventral striatum (vStr) contribute to movement initiation, transmitting information to CA1, while CA1 place cells dynamically encode new goal locations and relay spatial information to neurons in the dorsal striatum (dStr). This research provides a reliable platform for exploring the neural interactions between the striatum and hippocampus, establishing a foundation for future studies on neural circuits in complex behaviors.

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