JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Human placental mesenchymal stem cells and derived exosomes alleviate oxidative stress and ferroptosis via the Nrf2/GPX4 pathway in hemorrhagic shock-induced acute lung injury

Author(s): Shuai JIANG^1, ^2, ³, Qin ZHANG^1, ², Ping WANG^1, ², Mengxiao FENG^1, ², Congying SONG^1, ², Yuanqiang LU^1, ²
Affiliation(s): ¹Department of Emergency Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China ²Zhejiang Key Laboratory for Diagnosis and Treatment of Physic-chemical and Aging-related Injuries, Hangzhou 310003, China ³Department of Trauma Center and Traumatic Orthopedics, The Third Affiliated Hospital of Soochow University, Changzhou 213000, China
Corresponding email(s): Yuanqiang LU luyuanqiang@zju.edu.cn
Key Words: Hemorrhagic shock; Acute lung injury; Mesenchymal stem cells; Exosome; Ferroptosis

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Shuai JIANG^1,^2,³, Qin ZHANG^1,², Ping WANG^1,², Mengxiao FENG^1,², Congying SONG^1,², Yuanqiang LU^1,². Human placental mesenchymal stem cells and derived exosomes alleviate oxidative stress and ferroptosis via the Nrf2/GPX4 pathway in hemorrhagic shock-induced acute lung injury[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2500470

@article{title="Human placental mesenchymal stem cells and derived exosomes alleviate oxidative stress and ferroptosis via the Nrf2/GPX4 pathway in hemorrhagic shock-induced acute lung injury",
author="Shuai JIANG^1,^2,³, Qin ZHANG^1,², Ping WANG^1,², Mengxiao FENG^1,², Congying SONG^1,², Yuanqiang LU^1,²",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2500470"
}

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%T Human placental mesenchymal stem cells and derived exosomes alleviate oxidative stress and ferroptosis via the Nrf2/GPX4 pathway in hemorrhagic shock-induced acute lung injury
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%A Yuanqiang LU^1
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A1 - Qin ZHANG^{1
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Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Hemorrhagic shock (HS) induces acute lung injury (ALI) in the early phase. Mesenchymal stem cells (MSCs) have shown potential in ameliorating HS-induced ALI; however, the mechanisms involved remain unclear. Our study investigated the therapeutic effects of human placental mesenchymal stem cells (hPMSCs) on HS-induced ALI and explored the underlying mechanisms. Male Sprague-Dawley (SD) rats were used to establish a model of HS, and the treatment group received injected hPMSCs. The biodistribution of hPMSCs in various organs of rats was imaged with the in vivo imaging system (IVIS) spectrum imaging system. The therapeutic effect and potential mechanisms for hPMSCs to improve HS-induced ALI were evaluated. The lungs and liver of HS rats were the main migration targets after hPMSCs transplantation. HPMSCs markedly mitigated lung pathological damage and diminished levels of reactive oxygen species (ROS), malondialdehyde (MDA), and Fe2+ in the lungs of HS rats, while also enhancing glutathione peroxidase 4 (GPX4) protein expression. Exosomes derived from hPMSCs were taken up by rat alveolar type ࡱ epithelial (AT2) cells to inhibit ferroptosis by promoting overexpression of Nuclear factor erythroid 2-related factor 2 (Nrf2). Our study demonstrates the potential of hPMSC transplantation as a treatment for HS-induced ALI. The protective mechanism of hPMSCs for HS-induced ALI may include regulation of oxidative stress and ferroptosis.

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