Journal of Zhejiang University SCIENCE  B

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Oral Limosilactobacillus vaginalis administration prevents endometritis via endometritis-related bacteria and their metabolites in postpartum sows based on multi-omics analysis


Author(s):  Haoyi JIANG1, Longshan HAN1, Yifan HU1, Zhenhong YAN1, Qingbiao XU1, Xianghua YAN1, 2

Affiliation(s):  1National Key Laboratory of Agricultural Microbiology, Frontiers Science Center for Animal Breeding and Sustainable Production, Hubei Hongshan Laboratory, College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, 430070, China 2National Engineering Research Center for Green Feed and Healthy Breeding, Key Laboratory of Animal Molecular Nutrition, Ministry of Education, Key Laboratory of Animal Nutrition and Feed Science (Eastern of China), Ministry of Agriculture and Rural Affairs, Zhejiang Key Laboratory of Nutrition and Breeding for High-quality Animal Products Institute of Feed Science, College of Animal Science, Zhejiang University, Hangzhou, 310058, China

Corresponding email(s):  Xianghua YAN, xhyan2024@zju.edu.cn

Key Words:  Limosilactobacillus vaginalis; Sow endometritis; Gut microbiota; Vaginal microbiota; 16S rRNA sequencing; Liquid chromatography-tandem mass spectrometry (LC-MS/MS)


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Haoyi JIANG1, Longshan HAN1, Yifan HU1, Zhenhong YAN1, Qingbiao XU1, Xianghua YAN1,2. Oral Limosilactobacillus vaginalis administration prevents endometritis via endometritis-related bacteria and their metabolites in postpartum sows based on multi-omics analysis[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2500583

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journal="Journal of Zhejiang University Science B",
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publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2500583"
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%A Haoyi JIANG1
%A Longshan HAN1
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%A Xianghua YAN1
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doi="https://doi.org/10.1631/jzus.B2500583"

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A1 - Haoyi JIANG1
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A1 - Qingbiao XU1
A1 - Xianghua YAN1
A1 - 2
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doi="https://doi.org/10.1631/jzus.B2500583"


Abstract: Endometritis, a prevalent disease of the reproductive tract, significantly reduces sows' reproductive performance and thus leads to substantial economic losses. Limosilactobacillus vaginalis (LV) has been reported on its regulatory role in host immune capacity, while its mechanism of preventing endometritis remains unclear. Currently, no definitive diagnosis and effective treatment exists for this condition and antibiotics remain the most commonly used therapy. Herein, we investigated the potential of oral LV treatment as an effective antibiotic alternative for preventing endometritis in late-gestation sows. The results showed that orally administered LV significantly alleviated endometritis symptoms and moderately improved offspring growth performance. 16S rRNA sequencing revealed the significantly regulatory effects of LV on both gut and vaginal microbiota. Correspondingly, metabolic profiling indicated a shift towards better endometritis resistant landscape. Overall, the findings validate the roles of gut and vaginal microbiota as well as the utility of metabolic profiling in discovering the preventive effects of oral LV administration, establishing a link between intestinal probiotic supplementation and uterine health. Taken together, this study provides a novel antibiotic-free strategy for the treatment and prevention of sow endometritis.

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On-line Access: 2026-06-01

Received: 2025-09-14

Revision Accepted: 2025-12-15

Crosschecked: 0000-00-00

Cited: 0

Clicked: 85

Citations:  Bibtex RefMan EndNote GB/T7714

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