Journal of Zhejiang University SCIENCE  B

Accepted manuscript available online (unedited version)


Influence of pathological microenvironments on mesenchymal stem/stromal cell fate: role of long non-coding RNAs in bone-related diseases


Author(s):  Jingbo LAI1, 2, Ruolang PAN3, Jing ZHENG1, Ye CHEN1, 2

Affiliation(s):  1College of Life Sciences, and Department of Genetic and Metabolic Disease, The Children's Hospital Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Zhejiang University, Hangzhou 310058, China 2Zhejiang Key Laboratory of Cell and Molecular Intelligent Design and Development of Zhejiang Province, Hangzhou 310058, China 3Zhejiang Provincial Key Laboratory of Cell-Based Drug and Applied Technology Development, Institute for Cell-Based Drug Development of Zhejiang Province, Hangzhou 310018, China

Corresponding email(s):  Ye CHEN, yechency@zju.edu.cn Jing ZHENG, candy88zj@zju.edu.cn

Key Words:  Mesenchymal stem/stromal cells, Long non-coding RNA, Microenvironment, Cell Differentiation, Bone disease


Jingbo LAI1,2, Ruolang PAN3, Jing ZHENG1, Ye CHEN1,2. Influence of pathological microenvironments on mesenchymal stem/stromal cell fate: role of long non-coding RNAs in bone-related diseases[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2500699

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author="Jingbo LAI1,2, Ruolang PAN3, Jing ZHENG1, Ye CHEN1,2",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2500699"
}

%0 Journal Article
%T Influence of pathological microenvironments on mesenchymal stem/stromal cell fate: role of long non-coding RNAs in bone-related diseases
%A Jingbo LAI1
%A 2
%A Ruolang PAN3
%A Jing ZHENG1
%A Ye CHEN1
%A 2
%J Journal of Zhejiang University SCIENCE B
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%@ 1673-1581
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%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2500699"

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T1 - Influence of pathological microenvironments on mesenchymal stem/stromal cell fate: role of long non-coding RNAs in bone-related diseases
A1 - Jingbo LAI1
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A1 - Ruolang PAN3
A1 - Jing ZHENG1
A1 - Ye CHEN1
A1 - 2
J0 - Journal of Zhejiang University Science B
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%@ 1673-1581
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PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2500699"


Abstract: The bidirectional relationship between pathological microenvironments and mesenchymal stem/stromal cells (MSCs) is known as a pivotal factor influencing the progression of bone-related disease and therapeutic outcomes. MSCs, characterized by their remarkable plasticity and excellent immunomodulatory abilities, play central roles in various physiological and pathological processes, especially in bone regeneration and repair. Under pathological conditions, such as osteoarthritis, osteoporosis, or bone tumors, the tissue microenvironment can significantly alter MSC behavior, leading to impaired differentiation, dysregulated immune responses, or abnormal tissue remodeling. This dynamic relationship is regulated by diverse molecular signals, where long non-coding RNAs (lncRNAs) emerge as critical regulators of MSC biology. LncRNAs influence MSC differentiation, immunomodulatory functions, and responses to microenvironmental cues through diverse molecular mechanisms. The systematic review elucidates the roles of various lncRNAs involved in different aspects of MSC biology under pathological conditions and their potential as therapeutic targets or biomarkers for bone-related disorders.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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On-line Access: 2026-05-07

Received: 2025-10-30

Revision Accepted: 2026-04-19

Crosschecked: 0000-00-00

Cited: 0

Clicked: 479

Citations:  Bibtex RefMan EndNote GB/T7714

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