Journal of Zhejiang University

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Alternative splicing orchestration in skeletal muscle: from developmental programming to therapeutic targets in muscle disorders

Author(s): Wenhui CHENG¹, Hao CHEN¹, Xin'e SHI¹, Jianjun JIN¹
Affiliation(s): ¹The Laboratory of Animal Fat Deposition and Muscle Development, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China
Corresponding email(s): Jianjun JIN, jinjianjun2021@nwafu.edu.cn
Key Words: Alternative RNA splicing; skeletal muscle; myogenesis; muscle regeneration; muscle diseases.

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Wenhui CHENG¹, Hao CHEN¹, Xin'e SHI¹, Jianjun JIN¹. Alternative splicing orchestration in skeletal muscle: from developmental programming to therapeutic targets in muscle disorders[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2500834

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year="in press",
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doi="https://doi.org/10.1631/jzus.B2500834"

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Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Alternative RNA splicing represents a fundamental post-transcriptional regulatory mechanism that generates diverse mRNA transcripts from single genes, thereby expanding protein diversity beyond genomic constraints. In mammalian systems, over 95% of multi-exon genes undergo alternative splicing, with skeletal muscle exhibiting one of the highest frequencies of tissue-specific splicing events. This sophisticated regulatory process governs critical aspects of skeletal muscle development, regeneration, and functional maintenance. Dysregulation of alternative splicing pathways is intimately linked to devastating muscle disorders, including Duchenne muscular dystrophy (DMD), myotonic dystrophy (DM), and sarcopenia. This comprehensive review synthesizes current understanding of alternative splicing mechanisms, examines their pivotal roles in muscle growth and regeneration, and explores emerging therapeutic strategies that target splicing abnormalities in muscle disease.

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On-line Access: 2026-06-29

Received: 2025-12-18

Revision Accepted: 2026-06-01

Crosschecked: 0000-00-00

Cited: 0

Clicked: 10

Citations: Bibtex RefMan EndNote GB/T7714

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