Journal of Zhejiang University

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Enhancing the intestinal barrier with Bacteroides uniformis: a potential preventive strategy against swine enteric coronaviruses

Author(s): Huihua ZHEGN, Zheyi LIU, Xingyu DONG, Jinjia YANG, Junlong BI, Xiaodu WANG, Guanghong XIE, Dongbo SUN, Houhui SONG, Mingjun SU
Affiliation(s): Key Laboratory of Applied Biotechnology on Animal Science & Veterinary Medicine of Zhejiang Province, Zhejiang Engineering Research Center for Veterinary Diagnostics & Advanced Technology, Zhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health Management, Belt and Road International Joint Laboratory for One Health and Food Safety, China-Australia Joint Laboratory for Animal Health Big Data Analytics, College of Animal Science and Technology (College of Veterinary Medicine) of Zhejiang A&F University, Hangzhou, Zhejiang 311300, China; more
Corresponding email(s): Mingjunsu@zafu.edu.cn, songhh@zafu.edu.cn, Dongbosun@126.com
Key Words: Swine enteric coronaviruses (SECoVs); Porcine epidemic diarrhea virus (PEDV); Porcine deltacoronavirus (PDCoV); Intestinal barrier; Antiviral strategy; B. uniformis

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Huihua ZHEGN, Zheyi LIU, Xingyu DONG, Jinjia YANG, Junlong BI, Xiaodu WANG, Guanghong XIE, Dongbo SUN, Houhui SONG, Mingjun SU. Enhancing the intestinal barrier with Bacteroides uniformis: a potential preventive strategy against swine enteric coronaviruses[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2600197

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author="Huihua ZHEGN, Zheyi LIU, Xingyu DONG, Jinjia YANG, Junlong BI, Xiaodu WANG, Guanghong XIE, Dongbo SUN, Houhui SONG, Mingjun SU",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2600197"
}

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doi="https://doi.org/10.1631/jzus.B2600197"

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A1 - Jinjia YANG
A1 - Junlong BI
A1 - Xiaodu WANG
A1 - Guanghong XIE
A1 - Dongbo SUN
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A1 - Mingjun SU
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PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2600197"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Swine enteric coronaviruses (SECoVs) are major pathogens that cause acute, lethal diarrhea in neonatal piglets. To invade intestinal epithelial cells, SECoVs must first breach the intestinal barrier. Intestinal barrier function is relatively fragile in neonatal piglets due to their immature intestinal microecology and underdeveloped mucosal immunity. Furthermore, SECoVs can disrupt this barrier through multiple mechanisms, thereby accelerating infection. Consequently, maintaining intestinal barrier homeostasis represents a crucial strategic direction for the prevention and control of SECoVs infection. Intestinal probiotics and their metabolites play a critical role in maintaining intestinal barrier function, exerting protective effects by modulating the intestinal microecology, fortifying the mucus layer, enhancing tight junctions, and maintaining immune homeostasis. Bacteroides uniformis (B. uniformis), an important intestinal commensal bacterium, has demonstrated potential probiotic effects, including improvements in intestinal microecology and enhanced barrier function across various models of intestinal inflammation and metabolic disorder. However, direct evidence of its efficacy against SECoVs remains limited. This review therefore summarizes the mechanisms by which SECoVs disrupt the host intestinal barrier from microbial, chemical, physical, and immunological perspectives, and systematically outlines the potential roles of B. uniformis in barrier maintenance. The review thus provides a theoretical basis and identifies future research directions for the application of B. uniformis as a candidate probiotic for SECoVs prevention and control.

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On-line Access: 2026-07-16

Received: 2026-03-26

Revision Accepted: 2026-06-27

Crosschecked: 0000-00-00

Cited: 0

Clicked: 36

Citations: Bibtex RefMan EndNote GB/T7714

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