Journal of Zhejiang University

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Lipid metabolic networks in osteoarthritis pathogenesis: from sys-temic regulation to intrinsic control in chondrocytes

Author(s): Yan ZHAO1, Zitong DING1, Yan XUE2, Ziyuan YANG1, Jianan ZHANG3, Mengjie WU1
Affiliation(s): 1Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Hangzhou, China, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China; more
Corresponding email(s): wumengjie@zju.edu.cn
Key Words: Osteoarthritis, Lipid metabolism, Obesity, Gut microbiota, Synovial inflammation, Cartilage degeneration, Metabolic dysfunction.

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Yan ZHAO1, Zitong DING1, Yan XUE2, Ziyuan YANG1, Jianan ZHANG3, Mengjie WU1. Lipid metabolic networks in osteoarthritis pathogenesis: from sys-temic regulation to intrinsic control in chondrocytes[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2600231

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A1 - Jianan ZHANG3
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Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Osteoarthritis (OA) is a leading cause of chronic joint degeneration, and recent research increasingly highlights the pivotal role of lipid metabolism in its development. This review offers a comprehensive analysis of how systemic lipid metabolic dysfunction, local joint tissue remodeling, and intracellular lipid regulation in chondrocytes contribute to OA progression. We examine how obesity, dietary patterns, and gut microbiota imbalances promote systemic lipid disturbances, which, in turn, drive chronic inflammation and cartilage degradation. At the joint level, disrupted lipid metabolism in the infrapatellar fat pad (IPFP), synovial tissue, and macrophages creates a pro-inflammatory environment that accelerates cartilage damage. Additionally, alterations in intracellular lipid homeostasis in chondrocytes are linked to oxidative stress, mitochondrial dysfunction, and ferroptosis, which further contribute to cell death and joint destruction. This review presents an integrated framework that connects these multi-level lipid metabolic disturbances, emphasizing their combined effects on OA progression. It also explores emerging therapeutic strategies targeting lipid metabolic pathways at the systemic, local, and cellular levels. The findings provide a solid theoretical foundation for the development of precision therapies focused on lipid metabolism modulation, offering new possibilities for OA management and potential intervention.

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On-line Access: 2026-11-03

Received: 2026-04-08

Revision Accepted: 2026-07-17

Crosschecked: 0000-00-00

Cited: 0

Clicked: 25

Citations: Bibtex RefMan EndNote GB/T7714

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