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On-line Access: 2024-04-07
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Siyi LIN, Xinyu HE, Ying WANG, Yu CHEN, Aifu LIN. Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300497 @article{title="Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review", %0 Journal Article TY - JOUR
LncRNAs在机械转导中的作用及其与Hippo-YAP信号转导的关联1浙江大学医学院,中国杭州市,310058 2浙江大学生命科学学院,中国杭州市,310058 3浙江大学癌症研究院,中国杭州市,310058 4浙江省细胞与基因工程重点实验室,中国杭州市,310058 5浙江大学医学院附属第四医院国际医学院,中国义乌市,322000 6恶性肿瘤预警与干预教育部重点实验室,中国杭州市,310058 7浙江大学长三角智慧绿洲创新中心,中国嘉兴市,314100 摘要:细胞在组织中受到各种机械力的作用,包括静水压力、剪切应力、压缩和张力。这些机械刺激可通过机械感受器或细胞骨架依赖性反应过程转化为生化信号,从而塑造微环境,并维持细胞生理平衡。研究已证实转录共激活因子YAP/TAZ可作为机械转导因子,对细胞表型(如分化和疾病发病)产生动态影响。这种调节功能涉及细胞骨架、核骨架、整合素、局灶黏附蛋白(FA),以及多种信号通路的整合,包括细胞外信号调节蛋白激酶(ERK)、WNT和Hippo信号通路。此外,最新研究表明长链非编码RNA(lncRNA)可作为机械敏感分子在机械转导过程中发挥作用。本综述讨论了YAP/TAZ和lncRNA响应机械刺激的机制,并总结了参与机械转导的关键信号分子。 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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