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Ai-fu Lin


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Journal of Zhejiang University SCIENCE B 2024 Vol.25 No.4 P.280-292


Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review

Author(s):  Siyi LIN, Xinyu HE, Ying WANG, Yu CHEN, Aifu LIN

Affiliation(s):  College of Medicine, Zhejiang University, Hangzhou 310058, China; more

Corresponding email(s):   linaifu@zju.edu.cn

Key Words:  YAP/TAZ, Long non-coding RNA (lncRNA), Mechanotransduction, F-actin

Siyi LIN, Xinyu HE, Ying WANG, Yu CHEN, Aifu LIN. Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review[J]. Journal of Zhejiang University Science B, 2024, 25(4): 280-292.

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author="Siyi LIN, Xinyu HE, Ying WANG, Yu CHEN, Aifu LIN",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review
%A Siyi LIN
%A Xinyu HE
%A Ying WANG
%A Aifu LIN
%J Journal of Zhejiang University SCIENCE B
%V 25
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%P 280-292
%@ 1673-1581
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300497

T1 - Emerging role of lncRNAs as mechanical signaling molecules in mechanotransduction and their association with Hippo-YAP signaling: a review
A1 - Siyi LIN
A1 - Xinyu HE
A1 - Ying WANG
A1 - Yu CHEN
A1 - Aifu LIN
J0 - Journal of Zhejiang University Science B
VL - 25
IS - 4
SP - 280
EP - 292
%@ 1673-1581
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300497

Cells within tissues are subject to various mechanical forces, including hydrostatic pressure, shear stress, compression, and tension. These mechanical stimuli can be converted into biochemical signals through mechanoreceptors or cytoskeleton-dependent response processes, shaping the microenvironment and maintaining cellular physiological balance. Several studies have demonstrated the roles of Yes-associated protein (YAP) and its homolog transcriptional coactivator with PDZ-binding motif (TAZ) as mechanotransducers, exerting dynamic influence on cellular phenotypes including differentiation and disease pathogenesis. This regulatory function entails the involvement of the cytoskeleton, nucleoskeleton, integrin, focal adhesions (FAs), and the integration of multiple signaling pathways, including extracellular signal-regulated kinase (ERK), wingless/integrated (WNT), and Hippo signaling. Furthermore, emerging evidence substantiates the implication of long non-coding RNAs (lncRNAs) as mechanosensitive molecules in cellular mechanotransduction. In this review, we discuss the mechanisms through which YAP/TAZ and lncRNAs serve as effectors in responding to mechanical stimuli. Additionally, we summarize and elaborate on the crucial signal molecules involved in mechanotransduction.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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