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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2022-01-24
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3D-printed tissue repair patch combining mechanical support and magnetism for controlled skeletal muscle regeneration
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Xiaocheng Wang, Ruibo Zhao, Jian Wang, Xinghuan Li, Lijuan Jin, Wenyu Liu, Lifang Yang, Yonghua Zhu & Zhikai Tan. 3D-printed tissue repair patch combining mechanical support and magnetism for controlled skeletal muscle regeneration[J]. Journal of Zhejiang University Science D, 2022, 5(2): 249-264.
@article{title="3D-printed tissue repair patch combining mechanical support and magnetism for controlled skeletal muscle regeneration",
author="Xiaocheng Wang, Ruibo Zhao, Jian Wang, Xinghuan Li, Lijuan Jin, Wenyu Liu, Lifang Yang, Yonghua Zhu & Zhikai Tan",
journal="Journal of Zhejiang University Science D",
volume="5",
number="2",
pages="249-264",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00180-1"
}
%0 Journal Article
%T 3D-printed tissue repair patch combining mechanical support and magnetism for controlled skeletal muscle regeneration
%A Xiaocheng Wang
%A Ruibo Zhao
%A Jian Wang
%A Xinghuan Li
%A Lijuan Jin
%A Wenyu Liu
%A Lifang Yang
%A Yonghua Zhu & Zhikai Tan
%J Journal of Zhejiang University SCIENCE D
%V 5
%N 2
%P 249-264
%@ 1869-1951
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00180-1
TY - JOUR
T1 - 3D-printed tissue repair patch combining mechanical support and magnetism for controlled skeletal muscle regeneration
A1 - Xiaocheng Wang
A1 - Ruibo Zhao
A1 - Jian Wang
A1 - Xinghuan Li
A1 - Lijuan Jin
A1 - Wenyu Liu
A1 - Lifang Yang
A1 - Yonghua Zhu & Zhikai Tan
J0 - Journal of Zhejiang University Science D
VL - 5
IS - 2
SP - 249
EP - 264
%@ 1869-1951
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00180-1
Abstract: Physical forces, such as magnetic and mechanical stimulation, are known to play a significant role in the regulation of cell response. In the present study, a biomimetic regeneration patch was fabricated using E-jet 3D printing, which integrates mechanical and magnetic stimulation in a biocompatible “one-pot reaction” strategy when combined with a static magnetic field (SMF). The magneto-based therapeutic regeneration patch induced myoblasts to form aligned and multinucleated myotubes, regulated the expression of myogenic-related genes, and activated the p38α mitogen-activated protein kinase pathway via the initiation of myogenic differentiation. To validate the efficiency of the proposed strategy, the regeneration patch was implanted into mice and exposed to a suitable SMF, which resulted in significantly enhanced in vivo skeletal muscle regeneration. The findings demonstrated that appropriate external physical stimulation provides a suitable biophysical microenvironment that is conducive to tissue regeneration. The method used in the present study represents a promising technique to induce the regeneration of damaged skeletal muscle tissue.
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