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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2022-04-01
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3D-printed, bi-layer, biomimetic artificial periosteum for boosting bone regeneration
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Yage Sun, Ziwei Gao, Xiaoping Zhang, Ziyang Xu, Yahan Zhang, Binbin He, Rong Yang, Qian Zhang, Qiang Yang & Wenguang Liu. 3D-printed, bi-layer, biomimetic artificial periosteum for boosting bone regeneration[J]. Journal of Zhejiang University Science D, 2022, 5(3): 540-555.
@article{title="3D-printed, bi-layer, biomimetic artificial periosteum for boosting
bone regeneration",
author="Yage Sun, Ziwei Gao, Xiaoping Zhang, Ziyang Xu, Yahan Zhang, Binbin He, Rong Yang, Qian Zhang, Qiang Yang & Wenguang Liu",
journal="Journal of Zhejiang University Science D",
volume="5",
number="3",
pages="540-555",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-022-00191-6"
}
%0 Journal Article
%T 3D-printed, bi-layer, biomimetic artificial periosteum for boosting
bone regeneration
%A Yage Sun
%A Ziwei Gao
%A Xiaoping Zhang
%A Ziyang Xu
%A Yahan Zhang
%A Binbin He
%A Rong Yang
%A Qian Zhang
%A Qiang Yang & Wenguang Liu
%J Journal of Zhejiang University SCIENCE D
%V 5
%N 3
%P 540-555
%@ 1869-1951
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-022-00191-6
TY - JOUR
T1 - 3D-printed, bi-layer, biomimetic artificial periosteum for boosting
bone regeneration
A1 - Yage Sun
A1 - Ziwei Gao
A1 - Xiaoping Zhang
A1 - Ziyang Xu
A1 - Yahan Zhang
A1 - Binbin He
A1 - Rong Yang
A1 - Qian Zhang
A1 - Qiang Yang & Wenguang Liu
J0 - Journal of Zhejiang University Science D
VL - 5
IS - 3
SP - 540
EP - 555
%@ 1869-1951
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-022-00191-6
Abstract: Periosteum, a membrane covering the surface of the bone, plays an essential role in maintaining the function of bone tissue—and especially in providing nourishment and vascularization during the bone regeneration process. Currently, most
artificial periostea have relatively weak mechanical strength and a rapid degradation rate, and they lack integrated angiogenesis and osteogenesis functions. In this study, a bi-layer, biomimetic, artificial periosteum composed of a methacrylated
gelatin–nano-hydroxyapatite (GelMA-nHA) cambium layer and a poly (N-acryloyl 2-lycine) (PACG) -GelMA-Mg2+ fibrous
layer was fabricated via 3D printing. The GelMA-nHA layer is shown to undertake the function of improving osteogenic
differentiation of rat bone marrow mesenchymal stem cells with the sustainable release of Ca2+ from nHA nanoparticles. The
hydrogen-bonding-strengthened P(ACG-GelMA-L)-Mg2+ hydrogel layer serves to protect the inner defect site and prolong
degradation time (60 days) to match new bone regeneration. Furthermore, the released magnesium ion exhibits a prominent
effect in regulating the polarization phenotype of macrophage cells into the M2 phenotype and thus promotes the angiogenesis
of the human umbilical vein endothelial cells in vitro. This bi-layer artificial periosteum was implanted into a critical-sized
cranial bone defect in rats, and the 12-week post-operative outcomes demonstrate optimal new bone regeneration.
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