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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
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Benidipine-loaded nanoflower-like magnesium silicate improves bone regeneration
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Jingyi Lu, Miao Sun, Jingyu Zhang, Xiaofu Yang, Minyi Dong, Huihui He, An Liu, Mengfei Yu, Baixiang Wang & Huiming Wang. Benidipine-loaded nanoflower-like magnesium silicate improves bone regeneration[J]. Journal of Zhejiang University Science D, 2023, 6(5): 507–521.
@article{title="Benidipine-loaded nanoflower-like magnesium silicate improves bone regeneration",
author="Jingyi Lu, Miao Sun, Jingyu Zhang, Xiaofu Yang, Minyi Dong, Huihui He, An Liu, Mengfei Yu, Baixiang Wang & Huiming Wang",
journal="Journal of Zhejiang University Science D",
volume="6",
number="5",
pages="507–521",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-023-00240-8"
}
%0 Journal Article
%T Benidipine-loaded nanoflower-like magnesium silicate improves bone regeneration
%A Jingyi Lu
%A Miao Sun
%A Jingyu Zhang
%A Xiaofu Yang
%A Minyi Dong
%A Huihui He
%A An Liu
%A Mengfei Yu
%A Baixiang Wang & Huiming Wang
%J Journal of Zhejiang University SCIENCE D
%V 6
%N 5
%P 507–521
%@ 1869-1951
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-023-00240-8
TY - JOUR
T1 - Benidipine-loaded nanoflower-like magnesium silicate improves bone regeneration
A1 - Jingyi Lu
A1 - Miao Sun
A1 - Jingyu Zhang
A1 - Xiaofu Yang
A1 - Minyi Dong
A1 - Huihui He
A1 - An Liu
A1 - Mengfei Yu
A1 - Baixiang Wang & Huiming Wang
J0 - Journal of Zhejiang University Science D
VL - 6
IS - 5
SP - 507–521
EP -
%@ 1869-1951
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-023-00240-8
Abstract: Regeneration and reconstruction of bone tissue is always a challenge for clinicians due to the uncertainty of bone repair
materials in terms of long-term and efficient effects on osteoblasts. Here, we propose a novel strategy combining benidipine,
an antihypertensive drug and nanoparticles to synergistically promote the healing of bone defects. Loose and porous benidipineloaded magnesium silicate nanoparticles were prepared and validated for their biosafety. The nanoparticles were efficiently
taken up by preosteoblasts and uniformly distributed around the nucleus. After internalization into cells, the nanosystem
is degraded by lysosomes, and the effect of promoting osteogenic differentiation is reflected by the continuous release of
benidipine, silicon and magnesium ions. Our results clearly evaluated that the nanoflower-like magnesium silicate delivering
benidipine tends to be more appropriate for the bone regeneration in preosteoblasts, indicating that it might be a potential
approach in guiding bone repair in clinical applications.
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