Full Text:   <1466>

Summary:  <0>

CLC number: 

On-line Access: 2019-12-16

Received: 2019-10-07

Revision Accepted: 2019-12-04

Crosschecked: 2020-03-01

Cited: 0

Clicked: 1604

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Bio-Design and Manufacturing  2020 Vol.3 No.1 P.15-29

http://doi.org/10.1007/s42242-019-00056-5


3D printing of hydroxyapatite/tricalcium phosphate scafold with hierarchical porous structure for bone regeneration


Author(s):  Xiangjia Li, Yuan Yuan, Luyang Liu, Yuen‑Shan Leung, Yiyu Chen, Yuxing Guo, Yang Chai, Yong Chen

Affiliation(s):  Epstein Department of Industrial and Systems Engineering, University of Southern California, Los Angeles, USA; more

Corresponding email(s):   yongchen@usc.edu

Key Words:  3D printing, Slurry stereolithography, Scafold, HA/TCP, Hierarchical porosity


Share this article to: More

Xiangjia Li, Yuan Yuan, Luyang Liu, Yuen‑Shan Leung, Yiyu Chen, Yuxing Guo, Yang Chai, Yong Chen. 3D printing of hydroxyapatite/tricalcium phosphate scafold with hierarchical porous structure for bone regeneration[J]. Journal of Zhejiang University Science D, 2020, 3(1): 15-29.

@article{title="3D printing of hydroxyapatite/tricalcium phosphate scafold with hierarchical porous structure for bone regeneration",
author="Xiangjia Li, Yuan Yuan, Luyang Liu, Yuen‑Shan Leung, Yiyu Chen, Yuxing Guo, Yang Chai, Yong Chen",
journal="Journal of Zhejiang University Science D",
volume="3",
number="1",
pages="15-29",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-019-00056-5"
}

%0 Journal Article
%T 3D printing of hydroxyapatite/tricalcium phosphate scafold with hierarchical porous structure for bone regeneration
%A Xiangjia Li
%A Yuan Yuan
%A Luyang Liu
%A Yuen‑Shan Leung
%A Yiyu Chen
%A Yuxing Guo
%A Yang Chai
%A Yong Chen
%J Journal of Zhejiang University SCIENCE D
%V 3
%N 1
%P 15-29
%@ 1869-1951
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-019-00056-5

TY - JOUR
T1 - 3D printing of hydroxyapatite/tricalcium phosphate scafold with hierarchical porous structure for bone regeneration
A1 - Xiangjia Li
A1 - Yuan Yuan
A1 - Luyang Liu
A1 - Yuen‑Shan Leung
A1 - Yiyu Chen
A1 - Yuxing Guo
A1 - Yang Chai
A1 - Yong Chen
J0 - Journal of Zhejiang University Science D
VL - 3
IS - 1
SP - 15
EP - 29
%@ 1869-1951
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-019-00056-5


Abstract: 
Three-dimensional (3D)-printed scafolds have attracted considerable attention in recent years as they provide a suitable environment for bone cell tissue regeneration and can be customized in shape. Among many other challenges, the material composition and geometric structure have major impacts on the performance of scafolds. Hydroxyapatite and tricalcium phosphate (HA/TCP), as the major constituents of natural bone and teeth, possess attractive biological properties and are widely used in bone scafold fabrication. Many fabrication methods have been investigated in attempts to achieve HA/TCP scafolds with microporous structure enabling cell growth and nutrient transport. However, current 3D printing methods can only achieve the fabrication of HA/TCP scafolds with certain range of microporous structure. To overcome this challenge, we developed a slurry-based microscale mask image projection stereolithography, allowing us to form a HA/TCP-based photocurable suspension with complex geometry including biomimetic features and hierarchical porosity. Here, the curing performance and physical properties of the HA/TCP suspension were investigated, and a circular movement process for the fabrication of highly viscous HA/TCP suspension was developed. Based on these investigations, the scafold composition was optimized. We determined that a 30 wt% HA/TCP scafold with biomimetic hierarchical structure exhibited superior mechanical properties and porosity. Cell proliferation was investigated in vitro, and the surgery was conducted in a nude mouse in vivo model of long bone with cranial neural crest cells and bone marrow mesenchymal stem cells. The results showed our 3D-printed HA/TCP scafold with biomimetic hierarchical structure is biocompatible and has sufcient mechanical strength for surgery.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2022 Journal of Zhejiang University-SCIENCE