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On-line Access: 2025-07-30
Received: 2024-03-20
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Engineered inflammation-induced neurodevelopmental disorders using a neurovascular-unit-on-a-chip
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Rong Zou,Zhengdi Shi,Chengpan Li,Fan Xu,Xucai Zheng,Xiaofang Du,Dabing Huang,Bensheng Qiu,Weiping Ding. Engineered inflammation-induced neurodevelopmental disorders using a neurovascular-unit-on-a-chip[J]. Journal of Zhejiang University Science D, 2025, 8(4): 639–655.
@article{title="Engineered inflammation-induced neurodevelopmental disorders using a
neurovascular-unit-on-a-chip",
author="Rong Zou,Zhengdi Shi,Chengpan Li,Fan Xu,Xucai Zheng,Xiaofang Du,Dabing Huang,Bensheng Qiu,Weiping Ding",
journal="Journal of Zhejiang University Science D",
volume="8",
number="4",
pages="639–655",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400107"
}
%0 Journal Article
%T Engineered inflammation-induced neurodevelopmental disorders using a
neurovascular-unit-on-a-chip
%A Rong Zou
%A Zhengdi Shi
%A Chengpan Li
%A Fan Xu
%A Xucai Zheng
%A Xiaofang Du
%A Dabing Huang
%A Bensheng Qiu
%A Weiping Ding
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 4
%P 639–655
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400107
TY - JOUR
T1 - Engineered inflammation-induced neurodevelopmental disorders using a
neurovascular-unit-on-a-chip
A1 - Rong Zou
A1 - Zhengdi Shi
A1 - Chengpan Li
A1 - Fan Xu
A1 - Xucai Zheng
A1 - Xiaofang Du
A1 - Dabing Huang
A1 - Bensheng Qiu
A1 - Weiping Ding
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 4
SP - 639–655
EP -
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400107
Abstract: neuroinflammation is the primary driver and signature of many neurodevelopmental disorders. However, because neurode‐
velopmental disorders caused by neuroinflammation are difficult to detect at the early stage, their progression remains un‐
clear. To date, neither animal experiments nor in vitro models have uncovered their early developmental characteristics
caused by neuroinflammation. In this study, we developed a neurovascular-unit-on-a-chip (NVU-on-a-chip) to model
inflammation-induced neurodevelopmental disorders. With the chip, dynamic visualization of the progression caused by neu‐
roinflammation was clearly demonstrated, and the changes in angiogenesis and neural differentiation under neuroinflamma‐
tion were replicated. In addition, the activation of astrocytes and damage to neurons and capillaries at the early stage of neu‐
rodevelopmental disorders were observed. The results revealed for the first time the structural disruption of the neurovascular
units and the neurovascular coupling failure caused by neuroinflammation. Furthermore, the outcomes of anti-inflammatory
intervention using ibuprofen were preliminarily demonstrated. This work provides insights into the early progression of neu‐
rodevelopmental disorders caused by neuroinflammation and offers a platform for the development of therapeutic strategies
for neuroinflammation.
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