Full Text:
<1233>
Summary: 
<486>
Suppl. Mater.: 
CLC number:
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2022-07-06
Cited: 0
Clicked: 1395
ZNF750 facilitates carcinogenesis via promoting the expression of long non-coding RNA CYTOR and influences pharmacotherapy response in colon adenocarcinoma
| ||||||||||||||
Lu XIA, Hexin LIN, Yanming ZHOU, Jiabian LIAN. ZNF750 facilitates carcinogenesis via promoting the expression of long non-coding RNA CYTOR and influences pharmacotherapy response in colon adenocarcinoma[J]. Journal of Zhejiang University Science B, 2022, 23(7): 587-596.
@article{title="ZNF750 facilitates carcinogenesis via promoting the expression of long non-coding RNA CYTOR and influences pharmacotherapy response in colon adenocarcinoma",
author="Lu XIA, Hexin LIN, Yanming ZHOU, Jiabian LIAN",
journal="Journal of Zhejiang University Science B",
volume="23",
number="7",
pages="587-596",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2100939"
}
%0 Journal Article
%T ZNF750 facilitates carcinogenesis via promoting the expression of long non-coding RNA CYTOR and influences pharmacotherapy response in colon adenocarcinoma
%A Lu XIA
%A Hexin LIN
%A Yanming ZHOU
%A Jiabian LIAN
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 7
%P 587-596
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100939
TY - JOUR
T1 - ZNF750 facilitates carcinogenesis via promoting the expression of long non-coding RNA CYTOR and influences pharmacotherapy response in colon adenocarcinoma
A1 - Lu XIA
A1 - Hexin LIN
A1 - Yanming ZHOU
A1 - Jiabian LIAN
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 7
SP - 587
EP - 596
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100939
Abstract: The epidermal cell differentiation regulator zinc Finger Protein 750 (ZNF750) is a transcription factor containing the Cys2His2 (C2H2) domain, the zinc finger structure of which is located at the N-terminal 25–46 amino acids of ZNF750. It can promote the expression of differentiation-related factors while inhibiting the expression of progenitor cell-related genes. ZNF750 is directly regulated by p63 (encoded by the TP63 gene, belonging to the TP53 superfamily). The Krüppel-like factor 4 (KLF4), repressor element-1 (RE-1)-silencing transcription factor (REST) corepressor 1 (RCOR1), lysine demethylase 1A (KDM1A), and C-terminal-binding protein 1/2 (CTBP1/2) chromatin regulators cooperate with ZNF750 to repress epidermal progenitor genes and activate the expression of epidermal terminal differentiation genes (
[1]BianZH, ZhangJW, LiM, et al., 2017. Long non-coding RNA LINC00152 promotes cell proliferation, metastasis, and confers 5-FU resistance in colorectal cancer by inhibiting miR-139-5p. Oncogenesis, 6(11):395.
[2]BoxerLD, BarajasB, TaoSY, et al., 2014. ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. Genes Dev, 28(18):2013-2026.
[3]CaiJ, ZhangJ, WuP, et al., 2018. Blocking LINC00152 suppresses glioblastoma malignancy by impairing mesenchymal phenotype through the miR-612/AKT2/NF-κB pathway. J Neuro-Oncol, 140(2):225-236.
[4]CaiQ, WangZQ, WangSH, et al., 2016. Upregulation of long non-coding RNA LINC00152 by SP1 contributes to gallbladder cancer cell growth and tumor metastasis via PI3K/AKT pathway. Am J Transl Res, 8(10):4068-4081.
[5]CaiQ, WangZQ, WangSH, et al., 2017. Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial-mesenchymal transition by regulating HIF-1αvia miR-138. Open Biol, 7(1):160247.
[6]ChenPX, FangXL, XiaB, et al., 2018. Long noncoding RNA LINC00152 promotes cell proliferation through competitively binding endogenous miR-125b with MCL-1 by regulating mitochondrial apoptosis pathways in ovarian cancer. Cancer Med, 7(9):4530-4541.
[7]ChenQN, ChenX, ChenZY, et al., 2017. Long intergenic non-coding RNA 00152 promotes lung adenocarcinoma proliferation via interacting with EZH2 and repressing IL24 expression. Mol Cancer, 16:17.
[8]ChenSA, ShenX, 2020. Long noncoding RNAs: functions and mechanisms in colon cancer. Mol Cancer, 19:167.
[9]DengX, ZhaoXF, LiangXQ, et al., 2017. Linc00152 promotes cancer progression in hepatitis B virus-associated hepatocellular carcinoma. Biomed Pharmacother, 90:100-108.
[10]HaoJJ, LinDC, DinhHQ, et al., 2016. Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. Nat Genet, 48(12):1500-1507.
[11]HazawaM, LinDC, HandralH, et al., 2017. ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma. Oncogene, 36(16):2243-2254.
[12]JiJ, TangJW, DengL, et al., 2015. LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway. Oncotarget, 6(40):42813-42824.
[13]LuchiniC, BibeauF, LigtenbergMJL, et al., 2019. ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach. Ann Oncol, 30(8):1232-1243.
[14]MaP, WangHT, SunJY, et al., 2018. LINC00152 promotes cell cycle progression in hepatocellular carcinoma via miR-193a/b-3p/CCND1 axis. Cell Cycle, 17(8):974-984.
[15]OuCL, SunZQ, HeXY, et al., 2020. Targeting YAP1/LINC00152/FSCN1 signaling axis prevents the progression of colorectal cancer. Adv Sci, 7(3):1901380.
[16]PardollDM, 2012. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer, 12(4):252-264.
[17]QuJ, ZhangXQ, LvXY, 2020. Zinc finger protein 750 (ZNF750), negatively regulated by miR-17-5p, inhibits proliferation, motility and invasion of colonic cancer cells. J Gene Med, 22(8):e3195.
[18]SenGL, BoxerLD, WebsterDE, et al., 2012. ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation. Dev Cell, 22(3):669-677.
[19]ShanYQ, YingRC, JiaZ, et al., 2017. LINC00052 promotes gastric cancer cell proliferation and metastasis via activating the Wnt/β-catenin signaling pathway. Oncol Res, 25(9):1589-1599.
[20]ShenX, ZhongJX, YuP, et al., 2019. YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein. Biochem Biophys Res Commun, 509(2):448-454.
[21]SunZH, GuoX, ZangMC, et al., 2019. Long non-coding RNA LINC00152 promotes cell growth and invasion of papillary thyroid carcinoma by regulating the miR-497/BDNF axis. J Cell Physiol, 234(2):1336-1345.
[22]WangHF, ChenWX, YangP, et al., 2019. Knockdown of linc00152 inhibits the progression of gastric cancer by regulating microRNA-193b-3p/ETS1 axis. Cancer Biol Ther, 20(4):461-473.
[23]WangX, YuHF, SunWJ, et al., 2018. The long non-coding RNA CYTOR drives colorectal cancer progression by interacting with NCL and Sam68. Mol Cancer, 17:110.
[24]WangYJ, LiuJZ, BaiHZ, et al., 2017. Long intergenic non-coding RNA 00152 promotes renal cell carcinoma progression by epigenetically suppressing P16 and negatively regulates miR-205. Am J Cancer Res, 7(2):312-322.
[25]WenRH, ChenC, ZhongXH, et al., 2021. PAX6 upstream antisense RNA (PAUPAR) inhibits colorectal cancer progression through modulation of the microRNA (miR)-17-5p/zinc finger protein 750 (ZNF750) axis. Bioengineered, 12(1):3886-3899.
[26]XiaT, LiaoQ, JiangXM, et al., 2014. Long noncoding RNA associated-competing endogenous RNAs in gastric cancer. Sci Rep, 4:6088.
[27]XuJS, GuoJJ, JiangYK, et al., 2019. Improved characterization of the relationship between long intergenic non-coding RNA Linc00152 and the occurrence and development of malignancies. Cancer Med, 8(10):4722-4731.
[28]XuSP, WanL, YinHZ, et al., 2017. Long noncoding RNA Linc00152 functions as a tumor propellant in pan-cancer. Cell Physiol Biochem, 44(6):2476-2490.
[29]YuY, YangJ, LiQP, et al., 2017. LINC00152: a pivotal oncogenic long non-coding RNA in human cancers. Cell Prolif, 50(4):e12349.
[30]YuMJ, XueYX, ZhengJ, et al., 2017. Linc00152 promotes malignant progression of glioma stem cells by regulating miR-103a-3p/FEZF1/CDC25A pathway. Mol Cancer, 16:110.
[31]YueB, CaiDL, LiuCC, et al., 2016. Linc00152 functions as a competing endogenous RNA to confer oxaliplatin resistance and holds prognostic values in colon cancer. Mol Ther, 24(12):2064-2077.
[32]YueB, LiuCC, SunHM, et al., 2018. A positive feed-forward loop between LncRNA-CYTOR and Wnt/β-catenin signaling promotes metastasis of colon cancer. Mol Ther, 26(5):1287-1298.
[33]ZhangPP, HeQP, LeiY, et al., 2018. m6A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression. Cell Death Dis, 9(12):1169.
[34]ZhangYH, FuJ, ZhangZJ, et al., 2016. LncRNA-LINC00152 down-regulated by miR-376c-3p restricts viability and promotes apoptosis of colorectal cancer cells. Am J Transl Res, 8(12):5286-5297.
[35]ZhengLL, HuN, ZhouXZ, 2019. TCF3-activated LINC00152 exerts oncogenic role in osteosarcoma through regulating miR-1182/CDK14 axis. Pathol Res Pract, 215(2):373-380.
ORCID: 
Open peer comments: Debate/Discuss/Question/Opinion
<1>