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Protective effect of medium-chain monoglycerides on hepatic lipid accumulation via modulation of bile acid metabolism in Dongliao black pigs
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Nanhai XIAO1, Xutang WANG2, Jing WANG1,3, Fengqin FENG1,4, Minjie ZHAO1. Protective effect of medium-chain monoglycerides on hepatic lipid accumulation via modulation of bile acid metabolism in Dongliao black pigs[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Protective effect of medium-chain monoglycerides on hepatic lipid accumulation via modulation of bile acid metabolism in Dongliao black pigs",
author="Nanhai XIAO1, Xutang WANG2, Jing WANG1,3, Fengqin FENG1,4, Minjie ZHAO1",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2500239"
}
%0 Journal Article
%T Protective effect of medium-chain monoglycerides on hepatic lipid accumulation via modulation of bile acid metabolism in Dongliao black pigs
%A Nanhai XIAO1
%A Xutang WANG2
%A Jing WANG1
%A 3
%A Fengqin FENG1
%A 4
%A Minjie ZHAO1
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2500239
TY - JOUR
T1 - Protective effect of medium-chain monoglycerides on hepatic lipid accumulation via modulation of bile acid metabolism in Dongliao black pigs
A1 - Nanhai XIAO1
A1 - Xutang WANG2
A1 - Jing WANG1
A1 - 3
A1 - Fengqin FENG1
A1 - 4
A1 - Minjie ZHAO1
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2500239
Abstract: The aim of this study was to investigate the effects of feed supplementation with medium-chain monoglycerides (MG) on the growth performance, serum biochemistry, hepatic health, and gut microbiota of Dongliao black pigs. The results showed that 750 mg/kg of MG significantly increased body weight and slaughter rate, while it decreased feed conversion ratio and backfat thickness. In range of 250 mg/kg to 1000 mg/kg MG, there were no significant influences on glucolipid metabolism, the biomarkers of liver and kidney function, and appetite hormones in the serum. However, the control group exhibited massive hepatic lipid deposition, whereas this phenomenon was significantly alleviated after 750 mg/kg of MG intervention. The transcriptome results showed that 750 mg/kg of MG significantly increased the expression of genes related to cholesterol synthesis, cholesterol to bile acid conversion, bile acid glucuronidation, and bile acid reabsorption. Meanwhile, 750 mg/kg of MG prominently enhanced the concentration of total bile acid in the liver and feces. In brief, MG promoted the growth performance and improved the hepatic health of black pigs via the regulation of bile acid metabolism, therefore it has the potential to be used as a feed additive in finishing pigs, with an optimal dietary MG requirement of 750 mg/kg.
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