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On-line Access: 2021-12-14

Received: 2021-05-31

Revision Accepted: 2021-07-20

Crosschecked: 0000-00-00

Cited: 0

Clicked: 2541

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Shengnan SHEN

https://orcid.org/0000-0002-3964-8475

Yifeng LEI

https://orcid.org/0000-0002-3523-6887

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Journal of Zhejiang University SCIENCE B 2021 Vol.22 No.12 P.1022-1033

http://doi.org/10.1631/jzus.B2100644


3D printing of bioinspired compartmentalized capsular structure for controlled drug release


Author(s):  Jingwen LI, Mingxin WU, Wenhui CHEN, Haiyang LIU, Di TAN, Shengnan SHEN, Yifeng LEI, Longjian XUE

Affiliation(s):  School of Power and Mechanical Engineering, Wuhan University, Wuhan 430072, China; more

Corresponding email(s):   yifenglei@whu.edu.cn, Shen_Shengnan@whu.edu.cn

Key Words:  Three-dimensional (3D) printing, Bioinspired, Capsule, Bioink, Drug release


Jingwen LI, Mingxin WU, Wenhui CHEN, Haiyang LIU, Di TAN, Shengnan SHEN, Yifeng LEI, Longjian XUE. 3D printing of bioinspired compartmentalized capsular structure for controlled drug release[J]. Journal of Zhejiang University Science B, 2021, 22(12): 1022-1033.

@article{title="3D printing of bioinspired compartmentalized capsular structure for controlled drug release",
author="Jingwen LI, Mingxin WU, Wenhui CHEN, Haiyang LIU, Di TAN, Shengnan SHEN, Yifeng LEI, Longjian XUE",
journal="Journal of Zhejiang University Science B",
volume="22",
number="12",
pages="1022-1033",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2100644"
}

%0 Journal Article
%T 3D printing of bioinspired compartmentalized capsular structure for controlled drug release
%A Jingwen LI
%A Mingxin WU
%A Wenhui CHEN
%A Haiyang LIU
%A Di TAN
%A Shengnan SHEN
%A Yifeng LEI
%A Longjian XUE
%J Journal of Zhejiang University SCIENCE B
%V 22
%N 12
%P 1022-1033
%@ 1673-1581
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100644

TY - JOUR
T1 - 3D printing of bioinspired compartmentalized capsular structure for controlled drug release
A1 - Jingwen LI
A1 - Mingxin WU
A1 - Wenhui CHEN
A1 - Haiyang LIU
A1 - Di TAN
A1 - Shengnan SHEN
A1 - Yifeng LEI
A1 - Longjian XUE
J0 - Journal of Zhejiang University Science B
VL - 22
IS - 12
SP - 1022
EP - 1033
%@ 1673-1581
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100644


Abstract: 
Drug delivery with customized combinations of drugs, controllable drug dosage, and on-demand release kinetics is critical for personalized medicine. In this study, inspired by successive opening of layered structures and compartmentalized structures in plants, we designed a multiple compartmentalized capsular structure for controlled drug delivery. The structure was designed as a series of compartments, defined by the gradient thickness of their external walls and internal divisions. Based on the careful choice and optimization of bioinks composed of gelatin, starch, and alginate, the capsular structures were successfully manufactured by fused deposition modeling three-dimensional (3D) printing. The capsules showed fusion and firm contact between printed layers, forming complete structures without significant defects on the external walls and internal joints. Internal cavities with different volumes were achieved for different drug loading as designed. In vitro swelling demonstrated a successive dissolving and opening of external walls of different capsule compartments, allowing successive drug pulses from the capsules, resulting in the sustained release for about 410 min. The drug release was significantly prolonged compared to a single burst release from a traditional capsular design. The bioinspired design and manufacture of multiple compartmentalized capsules enable customized drug release in a controllable fashion with combinations of different drugs, drug doses, and release kinetics, and have potential for use in personalized medicine.

3D打印仿生多腔室药物控释胶囊

目的:设计并构建一种分时释放的药物胶囊,减缓药物释放速率,延长药物释放时间。
创新点:受植物多层、多级结构的启发,设计了一种多腔室、多壁厚的药物胶囊;并利用熔融沉积成型3D打印技术实现了一步成型。
方法:通过流变性能测试并优化生物墨水,以满足打印要求;基于熔融沉积成型3D打印技术制备了胶囊结构;通过扫描电镜(SEM)和计算机断层扫描(CT)表征打印的结构;并通过体外溶解实验评价其药物控释行为。
结论:该3D打印仿生多腔室结构,通过调节其腔室数量及其壁厚特性,实现了可控的药物释放。将来有望提高药物治疗的个体化用药程度。

关键词:3D打印;仿生;胶囊;生物墨水;药物控释

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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