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Received: 2020-06-30

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Bio-Design and Manufacturing  2020 Vol.3 No.3 P.203-226

http://doi.org/10.1007/s42242-020-00084-6


Engineered hydrogels for brain tumor culture and therapy


Author(s):  Jai Thakor, Samad Ahadian, Ali Niakan, Ethan Banton, Fatemeh Nasrollahi, Mohammad M. Hasani-Sadrabadi, Ali Khademhosseini

Affiliation(s):  Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, 570 Westwood Plaza, Los Angeles, CA 90095, USA; more

Corresponding email(s):   ahadian123@ucla.edu, khademh@terasaki.org

Key Words:  Brain tumor, Bioengineering, Cancer cells, Drug delivery, Hydrogel


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Jai Thakor, Samad Ahadian, Ali Niakan, Ethan Banton, Fatemeh Nasrollahi, Mohammad M. Hasani-Sadrabadi, Ali Khademhosseini. Engineered hydrogels for brain tumor culture and therapy[J]. Journal of Zhejiang University Science D, 2020, 3(3): 203-226.

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Abstract: 
brain tumors severity ranges from benign to highly aggressive and invasive. bioengineering tools can assist in understanding the pathophysiology of these tumors from outside the body and facilitate development of suitable antitumoral treatments. Here, we first describe the physiology and cellular composition of brain tumors. Then, we discuss the development of three-dimensional tissue models utilizing brain tumor cells. In particular, we highlight the role of hydrogels in providing a biomimetic support for the cells to grow into defined structures. Microscale technologies, such as electrospinning and bioprinting, and advanced cellular models aim to mimic the extracellular matrix and natural cellular localization in engineered tumor tissues. Lastly, we review current applications and prospects of hydrogels for therapeutic purposes, such as drug delivery and co-administration with other therapies. Through further development, hydrogels can serve as a reliable option for in vitro modeling and treatment of brain tumors for translational medicine.

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