Full Text:   <191>

CLC number: 

On-line Access: 2024-03-17

Received: 2023-12-06

Revision Accepted: 2024-02-20

Crosschecked: 0000-00-00

Cited: 0

Clicked: 271

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2300840


Three-dimensional breast cancer tumor models based on natural hydrogels: A review


Author(s):  Yan SHU, Bing LI, Hailin MA, Jiaqi LIU, Yuen Yee CHENG, Xiangqin LI, Tianqing LIU, Chuwei YANG, Xiao MA, Kedong SONG

Affiliation(s):  State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China; more

Corresponding email(s):   Kedongsong@dlut.edu.cn, realmaxiao@163.com, chinese_esquire@163.com

Key Words:  Breast cancer, Tumor microenvironment, 3D tumor models, Decellularized extracellular matrix, Natural scaffold materials


Yan SHU, Bing LI, Hailin MA, Jiaqi LIU, Yuen Yee CHENG, Xiangqin LI, Tianqing LIU, Chuwei YANG, Xiao MA, Kedong SONG. Three-dimensional breast cancer tumor models based on natural hydrogels: A review[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

@article{title="Three-dimensional breast cancer tumor models based on natural hydrogels: A review",
author="Yan SHU, Bing LI, Hailin MA, Jiaqi LIU, Yuen Yee CHENG, Xiangqin LI, Tianqing LIU, Chuwei YANG, Xiao MA, Kedong SONG",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300840"
}

%0 Journal Article
%T Three-dimensional breast cancer tumor models based on natural hydrogels: A review
%A Yan SHU
%A Bing LI
%A Hailin MA
%A Jiaqi LIU
%A Yuen Yee CHENG
%A Xiangqin LI
%A Tianqing LIU
%A Chuwei YANG
%A Xiao MA
%A Kedong SONG
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300840

TY - JOUR
T1 - Three-dimensional breast cancer tumor models based on natural hydrogels: A review
A1 - Yan SHU
A1 - Bing LI
A1 - Hailin MA
A1 - Jiaqi LIU
A1 - Yuen Yee CHENG
A1 - Xiangqin LI
A1 - Tianqing LIU
A1 - Chuwei YANG
A1 - Xiao MA
A1 - Kedong SONG
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300840


Abstract: 
breast cancer is the most common cancer in women and one of the deadliest cancers worldwide. According to the distribution of tumor tissue, breast cancer can be divided into invasive and non-invasive forms. The cancer cells in invasive breast cancer pass through the breast and through the immune system or systemic circulation to different parts of the body, forming metastatic breast cancer. Drug resistance and distant metastasis are the main causes of death from breast cancer. Research on breast cancer has attracted extensive attention from researchers. in vitro construction of tumor models by tissue engineering methods is a common tool for studying cancer mechanisms and anticancer drug screening. The tumor microenvironment consists of cancer cells and various types of stromal cells, including fibroblasts, endothelial cells, mesenchymal cells, and immune cells embedded in the extracellular matrix. The extracellular matrix contains fibrin proteins (such as I, II, III, IV, VI, type X collagen and elastin) and glycoproteins (such as proteoglycan, laminin and fibronectin), which are involved in cell signaling and binding of growth factors. The current traditional two-dimensional (2D) tumor models are limited by the growth environment and often cannot accurately reproduce the heterogeneity and complexity of tumor tissues in vivo. Therefore, in recent years, research on three-dimensional (3D) tumor models has gradually increased, especially 3D bioprinting models with high precision and repeatability. Compared with a 2D model, the 3D environment can better simulate the complex extracellular matrix components and structures in the tumor microenvironment. 3D models are often used as a bridge between 2D cellular level experiments and animal experiments. Acellular matrix, gelatin, sodium alginate and other natural materials are widely used in the construction of tumor models because of their excellent biocompatibility and non-immune rejection. Here, we review various natural scaffold materials and construction methods involved in 3D tissue engineered tumor models, as a reference for research in the field of breast cancer.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE