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On-line Access: 2021-01-22

Received: 2020-07-09

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Bio-Design and Manufacturing  2021 Vol.4 No.2 P.258-277

http://doi.org/10.1007/s42242-020-00104-5


Biofabrication of aligned structures that guide cell orientation and applications in tissue engineering


Author(s):  Kejie Lu, Ying Qian, Jiaxing Gong, Ziyu Zhu, Jun Yin, Liang Ma, Mengfei Yu & Huiming Wang

Affiliation(s):  The Affiliated Hospital of Stomatology, School of Stomatology, Zhejiang University School of Medicine, and Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou 310006, China; more

Corresponding email(s):   yumengfei@zju.edu.cn, whmwhm@zju.edu.cn

Key Words:  Aligned structures, Cell orientation, Electrospun nanofibers, Channeled structures, Micropatterns, Tissue engineering


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Kejie Lu, Ying Qian, Jiaxing Gong, Ziyu Zhu, Jun Yin, Liang Ma, Mengfei Yu & Huiming Wang. Biofabrication of aligned structures that guide cell orientation and applications in tissue engineering[J]. Journal of Zhejiang University Science D, 2021, 4(2): 258-277.

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Abstract: 
The organized alignment of cells in various tissues plays a significant role in the maintenance of specific functions. To induce such an alignment, ideal scaffolds should simulate the characteristics and morphologies of natural tissues. aligned structures that guide cell orientation are used to facilitate tissue regeneration and repair. We here review how various aligned structures are fabricated, including aligned electrospun nanofibers, aligned porous or channeled structures, micropatterns and combinations thereof, and their application in nerve, skeletal muscle, tendon, and tubular dentin regeneration. The future use of aligned structures in tissue engineering is also discussed.

浙江大学俞梦飞、王慧明等 | 定向结构的生物制造及其在组织工程中的应用

本综述论文聚焦定向结构的生物制造及其在组织工程中的应用。各种组织中细胞的定向排列在维持特定功能方面起着重要作用。为了诱导这种排列,理想的支架应该模拟天然组织的特征和形态。引导细胞定向的排列结构已被应用于促进组织再生和修复。本文回顾了各种定向结构的制造方法,包括定向静电纺丝纳米纤维、定向多孔或通道结构、微图案及其组合,以及它们在神经、骨骼肌、肌腱和管状牙本质再生中的应用,并讨论了定向结构在组织工程中的未来用途。

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