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On-line Access: 2021-01-22

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Bio-Design and Manufacturing  2021 Vol.4 No.2 P.258-277

http://doi.org/10.1007/s42242-020-00104-5


Biofabrication of aligned structures that guide cell orientation and applications in tissue engineering


Author(s):  Kejie Lu, Ying Qian, Jiaxing Gong, Ziyu Zhu, Jun Yin, Liang Ma, Mengfei Yu & Huiming Wang

Affiliation(s):  The Affiliated Hospital of Stomatology, School of Stomatology, Zhejiang University School of Medicine, and Key Laboratory of Oral Biomedical Research of Zhejiang Province, Hangzhou 310006, China; more

Corresponding email(s):   yumengfei@zju.edu.cn, whmwhm@zju.edu.cn

Key Words:  Aligned structures, Cell orientation, Electrospun nanofibers, Channeled structures, Micropatterns, Tissue engineering


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Kejie Lu, Ying Qian, Jiaxing Gong, Ziyu Zhu, Jun Yin, Liang Ma, Mengfei Yu & Huiming Wang. Biofabrication of aligned structures that guide cell orientation and applications in tissue engineering[J]. Journal of Zhejiang University Science D, 2021, 4(2): 258-277.

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author="Kejie Lu, Ying Qian, Jiaxing Gong, Ziyu Zhu, Jun Yin, Liang Ma, Mengfei Yu & Huiming Wang",
journal="Journal of Zhejiang University Science D",
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publisher="Zhejiang University Press & Springer",
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Abstract: 
The organized alignment of cells in various tissues plays a significant role in the maintenance of specific functions. To induce such an alignment, ideal scaffolds should simulate the characteristics and morphologies of natural tissues. aligned structures that guide cell orientation are used to facilitate tissue regeneration and repair. We here review how various aligned structures are fabricated, including aligned electrospun nanofibers, aligned porous or channeled structures, micropatterns and combinations thereof, and their application in nerve, skeletal muscle, tendon, and tubular dentin regeneration. The future use of aligned structures in tissue engineering is also discussed.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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