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Bio-Design and Manufacturing  2021 Vol.4 No.2 P.222-242

http://doi.org/10.1007/s42242-020-00122-3


Experimental and numerical characterization of 3D-printed scaffolds under monotonic compression with the aid of micro-CT volume reconstruction


Author(s):  R. Baptista, M. F. C. Pereira, A. Maurício, D. Rechena, V. Infante & M. Guedes

Affiliation(s):  CDP2T, Departamento de Engenharia Mecânica, Escola Superior de Tecnologia de Setúbal, Instituto Politécnico de Setúbal, 2910-761 Setúbal, Portugal; more

Corresponding email(s):   ricardo.baptista@estsetubal.ips.pt

Key Words:  Scaffold, Pore design, Mechanical behavior, Micro-CT analysis, Finite element method


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R. Baptista, M. F. C. Pereira, A. Maurício, D. Rechena, V. Infante & M. Guedes . Experimental and numerical characterization of 3D-printed scaffolds under monotonic compression with the aid of micro-CT volume reconstruction[J]. Journal of Zhejiang University Science D, 2021, 4(2): 222-242.

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Abstract: 
Even when damaged by injury or disease bone tissue has the remarkable ability to regenerate. When this process is limited by large size bone defects, tissue engineering is responsible for restoring, maintaining or improving tissue function. scaffolds are support structures, designed to be implanted in the damaged site, supporting mechanical loads and protecting the regenerating bone tissue. In this paper, 3D-printed PLA scaffolds with three different porosity values and two different geometries were experimentally and numerically characterized. micro-CT analysis showed that fused filament fabrication can be used to produce scaffolds with the desired porosity and 100% of interconnected pores. Under monotonical compression, scaffolds apparent compressive modulus increased from 89 to 918 MPa, while yield stress increased from 2.9 to 27.5 MPa as porosity decreased from 70 to 30%. Open porosity decreased up to 8% on aligned scaffolds and 14% on staggered scaffolds, after compression, while scaffold’s surface-to-volume ratio highest reduction (7.48 to 4.55 mm−1) was obtained with aligned low porosity scaffolds. Micro-CT volume reconstruction allowed for scaffold simplified numerical models to be built and analyzed. Excellent agreement was found when predicting scaffold’s apparent compressive modulus. Overall, it can be concluded that 3D printing is a viable scaffold manufacturing technique for trabecular bone replacement.

葡萄牙Ricardo Baptista等 | 三维打印支架在单调压缩下的实验和数值表征与微CT体积重建

即使因受伤或疾病而受损,骨组织也具有非凡的再生能力。当这个过程受到大尺寸骨缺损的限制时,组织工程可用来恢复、维持或改善组织功能。支架是支撑结构,设计用于植入受损部位,支撑机械载荷并保护再生骨组织。本文对具有三种不同孔隙率值和两种不同几何形状的3D打印PLA支架进行了实验和数值表征。微CT分析表明,熔丝制造可用于生产具有所需孔隙率和100%互连孔隙的支架。在单调压缩下,随着孔隙率从70%减少到30%,支架表观压缩模量从89 MPa增加到918 MPa,而屈服应力从2.9 MPa增加到27.5 MPa。压缩后,对齐支架的开放孔隙率降低了8%,交错支架的开放孔隙率降低了14%,而对齐的低孔隙率支架获得了支架的表面积与体积比最大的降低(7.48-4.55 mm-1)。微CT 体积重建能够构建和分析支架简化的数值模型。在预测支架的表观压缩模量时发现了极好的一致性。总的来说,可以得出结论,3D 打印是一种可行的骨小梁置换支架制造技术。

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