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Journal of Zhejiang University SCIENCE B 2024 Vol.25 No.1 P.65-82


Bioceramic scaffolds with two-step internal/external modification of copper-containing polydopamine enhance antibacterial and alveolar bone regeneration capability

Author(s):  Xiaojian JIANG, Lihong LEI, Weilian SUN, Yingming WEI, Jiayin HAN, Shuaiqi ZHONG, Xianyan YANG, Zhongru GOU, Lili CHEN

Affiliation(s):  Department of Oral Medicine, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; more

Corresponding email(s):   chenlili_1030@zju.edu.cn, zhrgou@zju.edu.cn

Key Words:  Copper-containing polydopamine, Modification, Antibacterial property, Bone regeneration, Angiogenesis, Bioceramic scaffold

Xiaojian JIANG, Lihong LEI, Weilian SUN, Yingming WEI, Jiayin HAN, Shuaiqi ZHONG, Xianyan YANG, Zhongru GOU, Lili CHEN. Bioceramic scaffolds with two-step internal/external modification of copper-containing polydopamine enhance antibacterial and alveolar bone regeneration capability[J]. Journal of Zhejiang University Science B, 2024, 25(1): 65-82.

@article{title="Bioceramic scaffolds with two-step internal/external modification of copper-containing polydopamine enhance antibacterial and alveolar bone regeneration capability",
author="Xiaojian JIANG, Lihong LEI, Weilian SUN, Yingming WEI, Jiayin HAN, Shuaiqi ZHONG, Xianyan YANG, Zhongru GOU, Lili CHEN",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Bioceramic scaffolds with two-step internal/external modification of copper-containing polydopamine enhance antibacterial and alveolar bone regeneration capability
%A Xiaojian JIANG
%A Lihong LEI
%A Weilian SUN
%A Yingming WEI
%A Jiayin HAN
%A Shuaiqi ZHONG
%A Xianyan YANG
%A Zhongru GOU
%A Lili CHEN
%J Journal of Zhejiang University SCIENCE B
%V 25
%N 1
%P 65-82
%@ 1673-1581
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B23d0004

T1 - Bioceramic scaffolds with two-step internal/external modification of copper-containing polydopamine enhance antibacterial and alveolar bone regeneration capability
A1 - Xiaojian JIANG
A1 - Lihong LEI
A1 - Weilian SUN
A1 - Yingming WEI
A1 - Jiayin HAN
A1 - Shuaiqi ZHONG
A1 - Xianyan YANG
A1 - Zhongru GOU
A1 - Lili CHEN
J0 - Journal of Zhejiang University Science B
VL - 25
IS - 1
SP - 65
EP - 82
%@ 1673-1581
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B23d0004

Magnesium-doped calcium silicate (CS) bioceramic scaffolds have unique advantages in mandibular defect repair; however, they lack antibacterial properties to cope with the complex oral microbiome. Herein, for the first time, the CS scaffold was functionally modified with a novel copper-containing polydopamine (PDA(Cu2+‍)) rapid deposition method, to construct internally modified (*P), externally modified (@PDA), and dually modified (*P@PDA) scaffolds. The morphology, degradation behavior, and mechanical properties of the obtained scaffolds were evaluated in vitro. The results showed that the CS*P@PDA had a unique micro-/nano-structural surface and appreciable mechanical resistance. During the prolonged immersion stage, the release of copper ions from the CS*P@PDA scaffolds was rapid in the early stage and exhibited long-term sustained release. The in vitro evaluation revealed that the release behavior of copper ions ascribed an excellent antibacterial effect to the CS*P@PDA, while the scaffolds retained good cytocompatibility with improved osteogenesis and angiogenesis effects. Finally, the PDA(Cu2+)-modified scaffolds showed effective early bone regeneration in a critical-size rabbit mandibular defect model. Overall, it was indicated that considerable antibacterial property along with the enhancement of alveolar bone regeneration can be imparted to the scaffold by the two-step PDA(Cu2+) modification, and the convenience and wide applicability of this technique make it a promising strategy to avoid bacterial infections on implants.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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