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On-line Access: 2021-06-21
Received: 2020-11-12
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Introducing 3D-potting: a novel production process for artificial membrane lungs with superior blood flow design
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Felix Hesselmann, Jannis M. Focke, Peter C. Schlanstein, Niklas B. Steuer, Andreas Kaesler, Sebastian D. Reinartz, Thomas Schmitz-Rode, Ulrich Steinseifer, Sebastian V. Jansen & Jutta Arens . Introducing 3D-potting: a novel production process for artificial membrane lungs with superior blood flow design[J]. Journal of Zhejiang University Science D, 2022, 5(1): 141-152.
@article{title="Introducing 3D-potting: a novel production process for artificial membrane lungs with superior blood flow design",
author="Felix Hesselmann, Jannis M. Focke, Peter C. Schlanstein, Niklas B. Steuer, Andreas Kaesler, Sebastian D. Reinartz, Thomas Schmitz-Rode, Ulrich Steinseifer, Sebastian V. Jansen & Jutta Arens ",
journal="Journal of Zhejiang University Science D",
volume="5",
number="1",
pages="141-152",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00139-2"
}
%0 Journal Article
%T Introducing 3D-potting: a novel production process for artificial membrane lungs with superior blood flow design
%A Felix Hesselmann
%A Jannis M. Focke
%A Peter C. Schlanstein
%A Niklas B. Steuer
%A Andreas Kaesler
%A Sebastian D. Reinartz
%A Thomas Schmitz-Rode
%A Ulrich Steinseifer
%A Sebastian V. Jansen & Jutta Arens
%J Journal of Zhejiang University SCIENCE D
%V 5
%N 1
%P 141-152
%@ 1869-1951
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00139-2
TY - JOUR
T1 - Introducing 3D-potting: a novel production process for artificial membrane lungs with superior blood flow design
A1 - Felix Hesselmann
A1 - Jannis M. Focke
A1 - Peter C. Schlanstein
A1 - Niklas B. Steuer
A1 - Andreas Kaesler
A1 - Sebastian D. Reinartz
A1 - Thomas Schmitz-Rode
A1 - Ulrich Steinseifer
A1 - Sebastian V. Jansen & Jutta Arens
J0 - Journal of Zhejiang University Science D
VL - 5
IS - 1
SP - 141
EP - 152
%@ 1869-1951
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00139-2
Abstract: Currently, artificial-membrane lungs consist of thousands of hollow fiber membranes where blood flows around the fibers and gas flows inside the fibers, achieving diffusive gas exchange. At both ends of the fibers, the interspaces between the hollow fiber membranes and the plastic housing are filled with glue to separate the gas from the blood phase. During a uniaxial centrifugation process, the glue forms the “potting.” The shape of the cured potting is then determined by the centrifugation process, limiting design possibilities and leading to unfavorable stagnation zones associated with blood clotting. In this study, a new multiaxial centrifugation process was developed, expanding the possible shapes of the potting and allowing for completely new module designs with potentially superior blood flow guidance within the potting margins. Two-phase simulations of the process in conceptual artificial lungs were performed to explore the possibilities of a biaxial centrifugation process and determine suitable parameter sets. A corresponding biaxial centrifugation setup was built to prove feasibility and experimentally validate four conceptual designs, resulting in good agreement with the simulations. In summary, this study shows the feasibility of a multiaxial centrifugation process allowing greater variety in potting shapes, eliminating inefficient stagnation zones and more favorable blood flow conditions in artificial lungs.
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