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Bio-Design and Manufacturing  2022 Vol.5 No.1 P.141-152

http://doi.org/10.1007/s42242-021-00139-2


Introducing 3D-potting: a novel production process for artificial membrane lungs with superior blood flow design


Author(s):  Felix Hesselmann, Jannis M. Focke, Peter C. Schlanstein, Niklas B. Steuer, Andreas Kaesler, Sebastian D. Reinartz, Thomas Schmitz-Rode, Ulrich Steinseifer, Sebastian V. Jansen & Jutta Arens

Affiliation(s):  Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute, RWTH Aachen University, Pauwelsstrasse 20, 52074, Aachen, Germany; more

Corresponding email(s):   hesselmann@ame.rwth-aachen.de

Key Words:  Potting process, Flow design, Membrane lung, Artificial lung, Hollow fiber membrane module, Manufacturing


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Felix Hesselmann, Jannis M. Focke, Peter C. Schlanstein, Niklas B. Steuer, Andreas Kaesler, Sebastian D. Reinartz, Thomas Schmitz-Rode, Ulrich Steinseifer, Sebastian V. Jansen & Jutta Arens . Introducing 3D-potting: a novel production process for artificial membrane lungs with superior blood flow design[J]. Journal of Zhejiang University Science D, 2022, 5(1): 141-152.

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author="Felix Hesselmann, Jannis M. Focke, Peter C. Schlanstein, Niklas B. Steuer, Andreas Kaesler, Sebastian D. Reinartz, Thomas Schmitz-Rode, Ulrich Steinseifer, Sebastian V. Jansen & Jutta Arens ",
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Abstract: 
Currently, artificial-membrane lungs consist of thousands of hollow fiber membranes where blood flows around the fibers and gas flows inside the fibers, achieving diffusive gas exchange. At both ends of the fibers, the interspaces between the hollow fiber membranes and the plastic housing are filled with glue to separate the gas from the blood phase. During a uniaxial centrifugation process, the glue forms the “potting.” The shape of the cured potting is then determined by the centrifugation process, limiting design possibilities and leading to unfavorable stagnation zones associated with blood clotting. In this study, a new multiaxial centrifugation process was developed, expanding the possible shapes of the potting and allowing for completely new module designs with potentially superior blood flow guidance within the potting margins. Two-phase simulations of the process in conceptual artificial lungs were performed to explore the possibilities of a biaxial centrifugation process and determine suitable parameter sets. A corresponding biaxial centrifugation setup was built to prove feasibility and experimentally validate four conceptual designs, resulting in good agreement with the simulations. In summary, this study shows the feasibility of a multiaxial centrifugation process allowing greater variety in potting shapes, eliminating inefficient stagnation zones and more favorable blood flow conditions in artificial lungs.

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