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On-line Access: 2021-07-21
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3D printing of patient‑specifc implants for osteochondral defects: workfow for an MRI‑guided zonal design
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David Kilian, Philipp Sembdner, Henriette Bretschneider, Tilman Ahlfeld, Lydia Mika, Jörg Lützner, Stefan Holtzhausen, Anja Lode, Ralph Stelzer, Michael Gelinsky. 3D printing of patient‑specifc implants for osteochondral defects: workfow for an MRI‑guided zonal design[J]. Journal of Zhejiang University Science D, 2021, 4(4): 818-832.
@article{title="3D printing of patient‑specifc implants for osteochondral defects: workfow for an MRI‑guided zonal design",
author="David Kilian, Philipp Sembdner, Henriette Bretschneider, Tilman Ahlfeld, Lydia Mika, Jörg Lützner, Stefan Holtzhausen, Anja Lode, Ralph Stelzer, Michael Gelinsky",
journal="Journal of Zhejiang University Science D",
volume="4",
number="4",
pages="818-832",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00153-4"
}
%0 Journal Article
%T 3D printing of patient‑specifc implants for osteochondral defects: workfow for an MRI‑guided zonal design
%A David Kilian
%A Philipp Sembdner
%A Henriette Bretschneider
%A Tilman Ahlfeld
%A Lydia Mika
%A Jörg Lützner
%A Stefan Holtzhausen
%A Anja Lode
%A Ralph Stelzer
%A Michael Gelinsky
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 4
%P 818-832
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00153-4
TY - JOUR
T1 - 3D printing of patient‑specifc implants for osteochondral defects: workfow for an MRI‑guided zonal design
A1 - David Kilian
A1 - Philipp Sembdner
A1 - Henriette Bretschneider
A1 - Tilman Ahlfeld
A1 - Lydia Mika
A1 - Jörg Lützner
A1 - Stefan Holtzhausen
A1 - Anja Lode
A1 - Ralph Stelzer
A1 - Michael Gelinsky
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 4
SP - 818
EP - 832
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00153-4
Abstract: magnetic resonance imaging (MRI) is a common clinical practice to visualize defects and to distinguish diferent tissue types
and pathologies in the human body. So far, MRI data have not been used to model and generate a patient-specifc design of
multilayered tissue substitutes in the case of interfacial defects. For orthopedic cases that require highly individual surgical
treatment, implant fabrication by additive manufacturing holds great potential. Extrusion-based techniques like 3D plotting allow the spatially defned application of several materials, as well as implementation of bioprinting strategies. With
the example of a typical multi-zonal osteochondral defect in an osteochondritis dissecans (OCD) patient, this study aimed
to close the technological gap between MRI analysis and the additive manufacturing process of an implant based on different biomaterial inks. A workfow was developed which covers the processing steps of MRI-based defect identifcation,
segmentation, modeling, implant design adjustment, and implant generation. A model implant was fabricated based on two
biomaterial inks with clinically relevant properties that would allow for bioprinting, the direct embedding of a patient’s own
cells in the printing process. As demonstrated by the geometric compatibility of the designed and fabricated model implant
in a stereolithography (SLA) model of lesioned femoral condyles, a novel versatile CAD/CAM workfow was successfully
established that opens up new perspectives for the treatment of multi-zonal (osteochondral) defects.
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