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Bio-Design and Manufacturing  2021 Vol.4 No.4 P.735-756

http://doi.org/10.1007/s42242-021-00149-0


Recent advances in design and applications of biomimetic self‑assembled peptide hydrogels for hard tissue regeneration


Author(s):  Haniyeh Najaf, Mahboobeh Jafari, Ghazal Farahavar, Samira Sadat Abolmaali, Negar Azarpira, Sedigheh Borandeh, Raheleh Ravanfar

Affiliation(s):  Pharmaceutical Nanotechnology Department, Shiraz University of Medical Sciences, 71345-1583 Shiraz, Iran; more

Corresponding email(s):   abolmaali@sums.ac.ir, s.abolmaali@gmail.com, raheleh@caltech.edu, rr699@cornell.edu, najaf.han@gmail.com, jafari.mahboob@gmail.com, gh_farahavar@yahoo.com, negarazarpira@gmail.com, sedigheh.borandeh@aalto.f

Key Words:  Haniyeh Najaf, Mahboobeh Jafari, Ghazal Farahavar, Samira Sadat Abolmaali, Negar Azarpira, Sedigheh Borandeh, Raheleh Ravanfar


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Haniyeh Najaf, Mahboobeh Jafari, Ghazal Farahavar, Samira Sadat Abolmaali, Negar Azarpira, Sedigheh Borandeh, Raheleh Ravanfar. Recent advances in design and applications of biomimetic self‑assembled peptide hydrogels for hard tissue regeneration[J]. Journal of Zhejiang University Science D, 2021, 4(4): 735-756.

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author="Haniyeh Najaf, Mahboobeh Jafari, Ghazal Farahavar, Samira Sadat Abolmaali, Negar Azarpira, Sedigheh Borandeh, Raheleh Ravanfar",
journal="Journal of Zhejiang University Science D",
volume="4",
number="4",
pages="735-756",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00149-0"
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%A Haniyeh Najaf
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%A Ghazal Farahavar
%A Samira Sadat Abolmaali
%A Negar Azarpira
%A Sedigheh Borandeh
%A Raheleh Ravanfar
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%I Zhejiang University Press & Springer
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A1 - Haniyeh Najaf
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A1 - Ghazal Farahavar
A1 - Samira Sadat Abolmaali
A1 - Negar Azarpira
A1 - Sedigheh Borandeh
A1 - Raheleh Ravanfar
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Abstract: 
The development of natural biomaterials applied for hard tissue repair and regeneration is of great importance, especially in societies with a large elderly population. Self-assembled peptide hydrogels are a new generation of biomaterials that provide excellent biocompatibility, tunable mechanical stability, injectability, trigger capability, lack of immunogenic reactions, and the ability to load cells and active pharmaceutical agents for tissue regeneration. Peptide-based hydrogels are ideal templates for the deposition of hydroxyapatite crystals, which can mimic the extracellular matrix. Thus, peptide-based hydrogels enhance hard tissue repair and regeneration compared to conventional methods. This review presents three major self-assembled peptide hydrogels with potential application for bone and dental tissue regeneration, including ionic selfcomplementary peptides, amphiphilic (surfactant-like) peptides, and triple-helix (collagen-like) peptides. Special attention is given to the main bioactive peptides, the role and importance of self-assembled peptide hydrogels, and a brief overview on molecular simulation of self-assembled peptide hydrogels applied for bone and dental tissue engineering and regeneration.

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