Full Text:   <3636>

CLC number: 

On-line Access: 2021-07-20

Received: 2021-03-08

Revision Accepted: 2021-06-12

Crosschecked: 0000-00-00

Cited: 0

Clicked: 2166

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Bio-Design and Manufacturing  2021 Vol.4 No.4 P.735-756

http://doi.org/10.1007/s42242-021-00149-0


Recent advances in design and applications of biomimetic self‑assembled peptide hydrogels for hard tissue regeneration


Author(s):  Haniyeh Najaf, Mahboobeh Jafari, Ghazal Farahavar, Samira Sadat Abolmaali, Negar Azarpira, Sedigheh Borandeh, Raheleh Ravanfar

Affiliation(s):  Pharmaceutical Nanotechnology Department, Shiraz University of Medical Sciences, 71345-1583 Shiraz, Iran; more

Corresponding email(s):   abolmaali@sums.ac.ir, s.abolmaali@gmail.com, raheleh@caltech.edu, rr699@cornell.edu, najaf.han@gmail.com, jafari.mahboob@gmail.com, gh_farahavar@yahoo.com, negarazarpira@gmail.com, sedigheh.borandeh@aalto.f

Key Words:  Haniyeh Najaf, Mahboobeh Jafari, Ghazal Farahavar, Samira Sadat Abolmaali, Negar Azarpira, Sedigheh Borandeh, Raheleh Ravanfar


Share this article to: More

Haniyeh Najaf, Mahboobeh Jafari, Ghazal Farahavar, Samira Sadat Abolmaali, Negar Azarpira, Sedigheh Borandeh, Raheleh Ravanfar. Recent advances in design and applications of biomimetic self‑assembled peptide hydrogels for hard tissue regeneration[J]. Journal of Zhejiang University Science D, 2021, 4(4): 735-756.

@article{title="Recent advances in design and applications of biomimetic self‑assembled peptide hydrogels for hard tissue regeneration",
author="Haniyeh Najaf, Mahboobeh Jafari, Ghazal Farahavar, Samira Sadat Abolmaali, Negar Azarpira, Sedigheh Borandeh, Raheleh Ravanfar",
journal="Journal of Zhejiang University Science D",
volume="4",
number="4",
pages="735-756",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00149-0"
}

%0 Journal Article
%T Recent advances in design and applications of biomimetic self‑assembled peptide hydrogels for hard tissue regeneration
%A Haniyeh Najaf
%A Mahboobeh Jafari
%A Ghazal Farahavar
%A Samira Sadat Abolmaali
%A Negar Azarpira
%A Sedigheh Borandeh
%A Raheleh Ravanfar
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 4
%P 735-756
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00149-0

TY - JOUR
T1 - Recent advances in design and applications of biomimetic self‑assembled peptide hydrogels for hard tissue regeneration
A1 - Haniyeh Najaf
A1 - Mahboobeh Jafari
A1 - Ghazal Farahavar
A1 - Samira Sadat Abolmaali
A1 - Negar Azarpira
A1 - Sedigheh Borandeh
A1 - Raheleh Ravanfar
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 4
SP - 735
EP - 756
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00149-0


Abstract: 
The development of natural biomaterials applied for hard tissue repair and regeneration is of great importance, especially in societies with a large elderly population. Self-assembled peptide hydrogels are a new generation of biomaterials that provide excellent biocompatibility, tunable mechanical stability, injectability, trigger capability, lack of immunogenic reactions, and the ability to load cells and active pharmaceutical agents for tissue regeneration. Peptide-based hydrogels are ideal templates for the deposition of hydroxyapatite crystals, which can mimic the extracellular matrix. Thus, peptide-based hydrogels enhance hard tissue repair and regeneration compared to conventional methods. This review presents three major self-assembled peptide hydrogels with potential application for bone and dental tissue regeneration, including ionic selfcomplementary peptides, amphiphilic (surfactant-like) peptides, and triple-helix (collagen-like) peptides. Special attention is given to the main bioactive peptides, the role and importance of self-assembled peptide hydrogels, and a brief overview on molecular simulation of self-assembled peptide hydrogels applied for bone and dental tissue engineering and regeneration.

加州理工学院Raheleh Ravanfar等 | 仿生自组装肽水凝胶在硬组织再生中的设计与应用进展

本综述论文聚焦自组装肽水凝胶在硬组织修复中的发展与应用研究。开发应用于硬组织修复和再生的天然生物材料非常重要,尤其是在老年人口较多的社会中更加凸显其重要性。自组装肽水凝胶是新一代生物材料,具有出色的生物相容性、可调机械稳定性、注射性和可控触发的能力,且较少触发排异反应,并可以承载细胞和活性药物用于组织再生。基于肽的水凝胶是羟基磷灰石晶体沉积的理想模板,可以模拟细胞外基质环境。因此,与传统方法相比,基于肽的水凝胶更能增强硬组织修复和再生。本文综述了三种主要的自组装肽水凝胶,包括离子自互补肽、两亲性(表面活性剂样)肽和三螺旋(胶原样)肽,它们具有在骨骼和牙齿组织再生方面的潜在应用。特别关注了主要的生物活性肽,自组装肽水凝胶的作用和重要性,并简要概述了用于骨骼和牙齿组织工程和再生的自组装肽水凝胶的分子模拟。

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE